ColoNet: Profiling Molecular and Cellular Networks in the Gastrointestinal Tract
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 4288
Special Issue Editors
Interests: mucosal immunology; t cells; cytokine networks; inflammatory bowel disease; colorectal cancer
Interests: translational immunology; T cell biology; inflammatory bowel disease; autoimmune diseases
2. Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), D-20246 Hamburg, Germany
Interests: systems biology; computational biology; adipose tissue; myeloid biology; erythropoiesis; metabolism; cancer therapy; mathematical modelling
Special Issue Information
Dear Colleagues,
There is a tight balance among the immune system, the intestinal epithelial surface and the commensal microbiota to defend against potential pathogens while preventing the development of chronic inflammatory conditions. The dysregulation of these tightly controlled mechanisms can lead to a vicious cycle and chronic inflammation, and is considered to be an underlying cause of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, the cues that link these components are only partially understood. Although the clinical manifestations of such diseases have been explicitly described, the etiology and pathogenesis of IBD and CRC have not yet been fully elucidated, and no curative therapeutic regimen has been developed to date. A precise description of these dynamic processes is a prerequisite for new interventions and the development of effective treatments for these diseases.
This Special Issue will focus on the molecular and cellular interplay from the mucosa to the intraepithelial layer, as well as the surrounding niches, such as the lamina propria, mesenteric adipose tissue and lymph nodes. Special interest is given to cytokines, metabolites, and microbial interactions from different compartments of the gut and the critical roles that they play in disease development. Recent technological advances allow the spatial and temporal profiling of molecular and cellular entities along the gastrointestinal tract and can, therefore, provide us with new insights into the pathogenesis of IBD and CRC. This issue will also include potentially new concepts derived from in vitro organoids, patient-derived material, or in vivo, utilizing murine model systems. Our vision is that the investigated molecular and cellular networks in the gastrointestinal tract will lay the foundation for translational approaches to combat IBD and CRC.
Prof. Dr. Samuel Huber
Dr. Penelope Felipe Pelczar
Dr. Lorenz Adlung
Guest Editors
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Keywords
- IBD
- inflammation
- colon cancer
- signaling
- systems biology
- immunology
- adipose tissue
- metabolism
- microbiome
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