ColoNet: Profiling Molecular and Cellular Networks in the Gastrointestinal Tract

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 4288

Special Issue Editors


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Guest Editor
Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Interests: mucosal immunology; t cells; cytokine networks; inflammatory bowel disease; colorectal cancer

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Guest Editor
Section of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Martinistr. 52, 20246 Hamburg, Germany
Interests: translational immunology; T cell biology; inflammatory bowel disease; autoimmune diseases

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Guest Editor
1. Medical Clinic and Polyclinic, University Medical Center Hamburg-Eppendorf (UKE), D-20246, Hamburg, Germany
2. Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf (UKE), D-20246 Hamburg, Germany
Interests: systems biology; computational biology; adipose tissue; myeloid biology; erythropoiesis; metabolism; cancer therapy; mathematical modelling

Special Issue Information

Dear Colleagues,

There is a tight balance among the immune system, the intestinal epithelial surface and the commensal microbiota to defend against potential pathogens while preventing the development of chronic inflammatory conditions. The dysregulation of these tightly controlled mechanisms can lead to a vicious cycle and chronic inflammation, and is considered to be an underlying cause of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, the cues that link these components are only partially understood. Although the clinical manifestations of such diseases have been explicitly described, the etiology and pathogenesis of IBD and CRC have not yet been fully elucidated, and no curative therapeutic regimen has been developed to date. A precise description of these dynamic processes is a prerequisite for new interventions and the development of effective treatments for these diseases.

This Special Issue will focus on the molecular and cellular interplay from the mucosa to the intraepithelial layer, as well as the surrounding niches, such as the lamina propria, mesenteric adipose tissue and lymph nodes. Special interest is given to cytokines, metabolites, and microbial interactions from different compartments of the gut and the critical roles that they play in disease development. Recent technological advances allow the spatial and temporal profiling of molecular and cellular entities along the gastrointestinal tract and can, therefore, provide us with new insights into the pathogenesis of IBD and CRC. This issue will also include potentially new concepts derived from in vitro organoids, patient-derived material, or in vivo, utilizing murine model systems. Our vision is that the investigated molecular and cellular networks in the gastrointestinal tract will lay the foundation for translational approaches to combat IBD and CRC.

Prof. Dr. Samuel Huber
Dr. Penelope Felipe Pelczar
Dr. Lorenz Adlung
Guest Editors

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Keywords

  • IBD
  • inflammation
  • colon cancer
  • signaling
  • systems biology
  • immunology
  • adipose tissue
  • metabolism
  • microbiome

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Published Papers (1 paper)

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Review

15 pages, 1844 KiB  
Review
The Memory T Cell “Communication Web” in Context with Gastrointestinal Disorders—How Memory T Cells Affect Their Surroundings and How They Are Influenced by It
by Annkathrin Knauss, Michael Gabel, Markus F. Neurath and Benno Weigmann
Cells 2022, 11(18), 2780; https://doi.org/10.3390/cells11182780 - 6 Sep 2022
Cited by 4 | Viewed by 3495
Abstract
Gut-related diseases like ulcerative colitis, Crohn’s disease, or colorectal cancer affect millions of people worldwide. It is an ongoing process finding causes leading to the development and manifestation of those disorders. This is highly relevant since understanding molecular processes and signalling pathways offers [...] Read more.
Gut-related diseases like ulcerative colitis, Crohn’s disease, or colorectal cancer affect millions of people worldwide. It is an ongoing process finding causes leading to the development and manifestation of those disorders. This is highly relevant since understanding molecular processes and signalling pathways offers new opportunities in finding novel ways to interfere with and apply new pharmaceuticals. Memory T cells (mT cells) and their pro-inflammatory properties have been proven to play an important role in gastrointestinal diseases and are therefore increasingly spotlighted. This review focuses on mT cells and their subsets in the context of disease pathogenesis and maintenance. It illustrates the network of regulatory proteins and metabolites connecting mT cells with other cell types and tissue compartments. Furthermore, the crosstalk with various microbes will be a subject of discussion. Characterizing mT cell interactions will help to further elucidate the sophisticated molecular and cellular networking system in the intestine and may present new ideas for future research approaches to control gut-related diseases. Full article
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