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Cells
Special Issues
Clinical and Methodological Aspects of HSC Transplantation in Hematological Malignancies
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Clinical and Methodological Aspects of HSC Transplantation in Hematological Malignancies

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 2899

Special Issue Editor

Prof. Dr. Luca Pierelli

E-Mail Website
Guest Editor
1. Immunohematology and Transfusion Medicine, San Camillo-Forlanini Hospital, 00152 Rome, Italy
2. Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
Interests: transfusion medicine; hematopoietic stem cell biology and transplantation; mesenchymal stem cell biology; adoptive immunotherapy and innate immunity biology; regenerative medicine

Special Issue Information

Dear Colleagues,

Since the mid-20th century, hematopoietic stem cell transplantation (HSCT) has been used to treat defective or leukemic hematopoiesis in congenital and acquired diseases. Since its first use, HSCT had developed and improved considerably, and today, it represents a unique opportunity to cure several hematological malignancies. Thanks to the current knowledge of immunogenetics, stem cell biology, the antineoplastic and immunosuppressive properties of several drugs, and ex vivo procedures, HSCT can be applied to treat patients within a wide age range, and can overcome HLA- and ABO-group barriers. The ability of HSCT to manage the main adverse immune effects (i.e., graft versus host disease), and to maintain its intended immune effects (i.e., graft versus malignancy), renders it a powerful therapeutic strategy for preventing disease relapse or progression, and an instructive model for the development of future cell therapies.  

Prof. Dr. Luca Pierelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hematopoietic stem cells
  • hematological malignancies
  • transplantation
  • ABO groups
  • HLA compatibility
  • stem cell mobilization
  • stem cell collection
  • stem cell freezing
  • acute leukemia
  • multiple myeloma
  • graft versus host prophylaxis
  • graft versus host treatment
  • extracorporeal photopheresis
  • haploidentical transplantation

Published Papers (3 papers)

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Review

18 pages, 526 KiB  
Review
Allogeneic Stem Cell Transplantation in Refractory Acute Myeloid Leukaemia
by Roberto Bono, Giuseppe Sapienza, Stefania Tringali, Cristina Rotolo, Caterina Patti, Antonino Mulè, Valeria Calafiore, Alessandra Santoro and Luca Castagna
Cells 2024, 13(9), 755; https://doi.org/10.3390/cells13090755 - 26 Apr 2024
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Abstract
Refractory acute myeloid leukaemia is very difficult to treat and represents an unmet clinical need. In recent years, new drugs and combinations of drugs have been tested in this category, with encouraging results. However, all treated patients relapsed and died from the disease. [...] Read more.
Refractory acute myeloid leukaemia is very difficult to treat and represents an unmet clinical need. In recent years, new drugs and combinations of drugs have been tested in this category, with encouraging results. However, all treated patients relapsed and died from the disease. The only curative option is allogeneic transplantation through a graft from a healthy donor immune system. Using myeloablative conditioning regimens, the median overall survival regimens is 19%. Several so-called sequential induction chemotherapies followed by allogeneic transplantation conditioned by reduced intensity regimens have been developed, improving the overall survival to 25–57%. In the allogeneic transplantation field, continuous improvements in practices, particularly regarding graft versus host disease prevention, infection prevention, and treatment, have allowed us to observe improvements in survival rates. This is true mainly for patients in complete remission before transplantation and less so for refractory patients. However, full myeloablative regimens are toxic and carry a high risk of treatment-related mortality. In this review, we describe the results obtained with the different modalities used in more recent retrospective and prospective studies. Based on these findings, we speculate how allogeneic stem cell transplantation could be modified to maximise its therapeutic effect on refractory acute myeloid leukaemia. Full article
(This article belongs to the Special Issue Clinical and Methodological Aspects of HSC Transplantation in Hematological Malignancies)
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18 pages, 1315 KiB  
Review
Stem Cells Collection and Mobilization in Adult Autologous/Allogeneic Transplantation: Critical Points and Future Challenges
by Michele Prisciandaro, Enrico Santinelli, Valeria Tomarchio, Maria Antonietta Tafuri, Cecilia Bonchi, Gloria Palazzo, Carolina Nobile, Alessandra Marinucci, Marcella Mele, Ombretta Annibali, Luigi Rigacci and Michele Vacca
Cells 2024, 13(7), 586; https://doi.org/10.3390/cells13070586 - 28 Mar 2024
Viewed by 715
Abstract
Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and [...] Read more.
Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and collection facility within a transplant program encompass augmenting mobilization efficiency to optimize the harvest of target cell populations, implementing robust monitoring and predictive strategies for mobilization, streamlining the apheresis procedure to minimize collection duration while ensuring adequate yield, prioritizing patient comfort by reducing the overall collection time, guaranteeing the quality and purity of stem cell products to optimize graft function and transplant success, and facilitating seamless coordination between diverse entities involved in the HSCT process. In this review, we aim to address key questions and provide insights into the critical aspects of mobilizing and collecting hematopoietic stem cells for transplantation purposes. Full article
(This article belongs to the Special Issue Clinical and Methodological Aspects of HSC Transplantation in Hematological Malignancies)
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21 pages, 1083 KiB  
Review
Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation
by Mauro Di Ianni, Carmine Liberatore, Nicole Santoro, Paola Ranalli, Francesco Guardalupi, Giulia Corradi, Ida Villanova, Barbara Di Francesco, Stefano Lattanzio, Cecilia Passeri, Paola Lanuti and Patrizia Accorsi
Cells 2024, 13(2), 134; https://doi.org/10.3390/cells13020134 - 11 Jan 2024
Viewed by 1306
Abstract
GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell [...] Read more.
GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK-cell-based immunotherapies, and suicide gene therapies in order to prevent GvHD and maximally amplify the GvL effect in the setting of haploidentical transplantation. Full article
(This article belongs to the Special Issue Clinical and Methodological Aspects of HSC Transplantation in Hematological Malignancies)
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