Mechanisms of Respiratory Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 August 2024 | Viewed by 916

Special Issue Editors


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Guest Editor
CNRS, INEM, UMR7355, University of Orleans, 45071 Orleans, France
Interests: injury-induced inflammation; chronic progressive respiratory diseases; viral superinfection; innate immune danger sensing; cGAS/STING; inflammasome activation; IL-1 family; Th2; Th17; altered microbiota; metabolites; tissue homeostasis; inflammatory responses; translational research in mouse models of human disease
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Guest Editor
Microviable Therapeutics S.L., Oviedo, Asturias, Spain
Interests: host-microbiome interactions in the context of health and disease; development of microbiome-based therapies and biological drugs; bacterial metabolites and their interactions with the host's immune system, with a special focus on products of bacterial fermentation such as short-chain fatty acids and branched short-chain fatty acids

Special Issue Information

Dear Colleagues,

Understanding the mechanisms of respiratory diseases related to environmental exposure is a major challenge. The focus of this Special Issue is on the research of stressors such as particles, smoke, ozone or other inhaled agents activating inflammatory pathways and non-resolving, progressive lung destruction and fibrosis and exacerbation by viral infections. Contributions are invited that help to understand the role of innate receptors such as TLR, NLRP, cGAS/STING, ferroptosis, autophagy, senescence or cytokines such as IL-1, TNF and FASL to elicit host innate immune responses leading to inflammatory diseases.

The interplay between altered microbiota composition and metabolites linked to inflammation is a factor to be considered in pathogenesis. Translational contributions including defined inhibitors in rodents and human cell culture are of interest, and recent discoveries for this thematic issue of Cells are welcome.

Prof. Dr. Bernhard Ryffel
Dr. David Rios-Covián
Guest Editors

Manuscript Submission Information

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Keywords

  • cell death/stress
  • DNA/RNA sensor
  • cGAS/STING
  • inflammasome
  • microbiome
  • FMT or transfer of bacteria
  • metabolite
  • viral infection
  • emphysema
  • progressive fibrosis
  • innate immune response
  • defined inhibitors

Published Papers (1 paper)

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Review

18 pages, 982 KiB  
Review
Unlocking the Future: Pluripotent Stem Cell-Based Lung Repair
by Tobias Goecke, Fabio Ius, Arjang Ruhparwar and Ulrich Martin
Cells 2024, 13(7), 635; https://doi.org/10.3390/cells13070635 - 5 Apr 2024
Viewed by 752
Abstract
The human respiratory system is susceptible to a variety of diseases, ranging from chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis to acute respiratory distress syndrome (ARDS). Today, lung diseases represent one of the major challenges to the health care sector and represent [...] Read more.
The human respiratory system is susceptible to a variety of diseases, ranging from chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis to acute respiratory distress syndrome (ARDS). Today, lung diseases represent one of the major challenges to the health care sector and represent one of the leading causes of death worldwide. Current treatment options often focus on managing symptoms rather than addressing the underlying cause of the disease. The limitations of conventional therapies highlight the urgent clinical need for innovative solutions capable of repairing damaged lung tissue at a fundamental level. Pluripotent stem cell technologies have now reached clinical maturity and hold immense potential to revolutionize the landscape of lung repair and regenerative medicine. Meanwhile, human embryonic (HESCs) and human-induced pluripotent stem cells (hiPSCs) can be coaxed to differentiate into lung-specific cell types such as bronchial and alveolar epithelial cells, or pulmonary endothelial cells. This holds the promise of regenerating damaged lung tissue and restoring normal respiratory function. While methods for targeted genetic engineering of hPSCs and lung cell differentiation have substantially advanced, the required GMP-grade clinical-scale production technologies as well as the development of suitable preclinical animal models and cell application strategies are less advanced. This review provides an overview of current perspectives on PSC-based therapies for lung repair, explores key advances, and envisions future directions in this dynamic field. Full article
(This article belongs to the Special Issue Mechanisms of Respiratory Diseases)
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