Cellular and Clinical Mechanisms of Obesity and Diabetes and Their Complications
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 15 January 2025 | Viewed by 1995
Special Issue Editors
Interests: investigation of the molecular mechanisms involved in growth hormone disorders; investigation of oxidative stress mechanisms in type 1 diabetes mellitus; investigation of signaling pathways involved in pediatric and adult obesity; investigation of genetics and syndromic forms of congenital hyperinsulinism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity represents a global public health challenge with increasing prevalence and increased morbidity and mortality rates. It is a chronic and heterogeneous disorder characterized by the excessive accumulation of adipose tissue and regulated by multiple pathways. Its association with complications, including insulin resistance, type 2 diabetes, dyslipidemia, hypertension, non-alcoholic fatty liver disease and cardiovascular disease, is well established. Extensive research has elucidated many of the mechanisms implicated in obesity-related metabolic dysregulation and its complications, resulting in tremendous achievements in the fight against obesity.
In addition, diabetes, one of the most common metabolic disorders, is another global medical threat with increasing prevalence. Type 1 diabetes is caused by the autoimmune destruction of β-cells, whereas type 2 diabetes is characterized by the synergistic role of defective insulin secretion by pancreatic β-cells and the reduced responsiveness of insulin-sensitive tissues to insulin. The molecular mechanisms implicated in the synthesis and release of insulin and pathological conditions perpetuating β-cell destruction or insulin resistance, such as nutritional factors, physical activity, gut dysbiosis and metabolic memory, have been investigated thoroughly.
This Special Issue aims to summarize the current knowledge on the clinical and cellular mechanisms implicated in obesity and diabetes, with the intention of broadening the understanding of these major metabolic disorders and their complications.
We look forward to your contributions.
Dr. Eirini Kostopoulou
Dr. María Güemes
Guest Editors
Manuscript Submission Information
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Keywords
- obesity
- type 1 diabetes
- type 2 diabetes
- metabolic disorders
- complications
- signaling pathways
- pathophysiology
- insulin
- β-cell
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