Polarization in Cell
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1554
Special Issue Editor
Special Issue Information
Dear Colleagues,
Almost all cells are spatially asymmetric, i.e., they are polarized. The focus of this Special Issue is on eukaryotes, even though most prokaryote and archaea cells also have polarity. We have learned a great deal about cell polarity from studying single cell eukaryotes, especially the yeast S. cerevisiae, which has been a major model system for most aspects of cell biology. Many of the molecular mechanisms of polarity that are reviewed in this Special Issue, such as the exocyst, were first discovered in S. cerevisiae.
Cell polarity plays an especially important role in metazoa, i.e., multicellular animals. Cells in metazoa are organized into tissues. The most basic type of tissue in animals is epithelial tissue, in which epithelial cells are arranged in a monolayer of cells that forms a barrier separating two compartments. An outer layer of epithelium covers the outside of the organism, such as the epidermis in mammals. In the simplest animals, such as hydras, there is a single internal cavity or tube, lined by a layer of epithelial cells. In more complex metazoans, such as mammals, there are many interior organ systems, such as the gastrointestinal, respiratory, urinary and vascular systems, each lined by a single layer of specialized epithelial cells. In almost all cases, these epithelial cells are highly polarized, and much of this volume is focused on epithelial cells, both because their polarity has been very well examined and because of their relevance to human medicine.
Prof. Dr. Keith E. Mostov
Guest Editor
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Keywords
- cell polarity
- epithelial polarity
- neuronal polarity
- membrane traffic
- apical surface
- basolateral surface
