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New Trends and Advances in Diagnosis and Prognosis of Head...
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New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 2383

Special Issue Editors

Dr. Piotr Cierpikowski

E-Mail Website
Guest Editor
Department of Maxillofacial Surgery, The Ludwik Rydygier Specialist Hospital, Krakow, Poland
Interests: head and neck cancer; maxillofacial surgery; prognostic biomarkers; cancer biology; immunohistochemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julia Bar

E-Mail Website
Guest Editor
Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Wroclaw, Poland
Interests: stem cell biology; regenerative medicine; immunopathology; molecular biology; cancer stem cells biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Head and neck cancer is a heterogenous malignancy with high mortality and increasing incidence worldwide. Late diagnosis, rapid tumour growth, poor response to radiochemotherapy and early local recurrence are still key challenges in modern treatment. Growing evidence suggests that the highly aggressive behaviour of head and neck cancer may be an effect of cancer stem cells and abnormalities in the signalling pathways associated with them. Despite recent advances in therapeutic strategies, the 5-year survival rate has remained stable in recent decades at about 50%. For this reason, further studies elucidating head and neck cancer biology are urgently required to improve the survival of patients.
    
We are delighted to present this Special Issue of Cells that is focused on the latest advances and future trends in the diagnosis, prognosis and treatment of head and neck cancer. This Special Issue will present original research articles as well as up-to-date review papers that present cellular and molecular mechanisms of head and neck cancer and, in particular, new specific biomarkers or potential therapy targets that may allow us to better stratify the prognosis of patients and improve their clinical outcome. We would like to encourage head and neck cancer researchers around the world to submit their manuscripts to this Special Issue.

Dr. Piotr Cierpikowski
Prof. Dr. Julia Bar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • oral cancer
  • biomarker
  • prognosis
  • carcinogenesis
  • oral premalignant lesions
  • cancer stem cells
  • signaling pathways
  • molecular targeted therapy

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Related Special Issue

Published Papers (2 papers)

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Research

14 pages, 1939 KiB  
Article
Comparison of Tumor Microenvironments between Primary Tumors and Lymph Node Metastases in Head and Neck Squamous Cell Carcinoma and Their Predictive Role in Immune Checkpoint Inhibitor Treatment
by Dong Hyun Kim, Jong Seok Ahn, Mingu Kang, Gahee Park, Yoojoo Lim, Soohyun Hwang, Chan-Young Ock, Jiwon Koh, Eun-Jae Chung, Seong-Keun Kwon, Yoon Kyung Jeon, Kyeong Cheon Jung, Soon-Hyun Ahn and Bhumsuk Keam
Cells 2024, 13(18), 1557; https://doi.org/10.3390/cells13181557 - 16 Sep 2024
Viewed by 730
Abstract
The relationship between tumor microenvironments (TMEs) of regional lymph node metastases (LNMs) and primary tumors in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study compared tumor-infiltrating lymphocytes (TILs) and the immune phenotype (IP), characterized by spatial TIL distribution, between primary [...] Read more.
The relationship between tumor microenvironments (TMEs) of regional lymph node metastases (LNMs) and primary tumors in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study compared tumor-infiltrating lymphocytes (TILs) and the immune phenotype (IP), characterized by spatial TIL distribution, between primary tumors and LNMs. Twenty-one HNSCC patients with regional LNM who received immune checkpoint inhibitors (ICIs) were included. A paired comparative analysis of TIL densities and IP between primary tumors and LNMs revealed no significant difference or correlation between TIL densities in primary tumors and LNMs. Their IPs were discordant in 12 patients (57.1%). Patients with high intratumoral TIL exhibited longer progression-free survival (PFS) than those with low intratumoral TIL in both primary tumors (median, 5.2 vs. 1.3 months, p = 0.003) and LNMs (median, 30.2 vs. 1.3 months, p = 0.012). Patients with inflamed IP exhibited longer PFS than those with non-inflamed IP in both primary tumors (median, 4.5 vs. 1.3 months, p = 0.043) and LNMs (median, 4.1 vs. 1.3 months, p = 0.037). Given the lack of correlation in TIL densities, the discrepancies in IP, and the predictive value of both TMEs, evaluating the TMEs of both primary tumors and LNMs may be beneficial for the precise use of ICIs in HNSCC. There was a significant discordance between the TME of primary tumors and LNMs, with implications in survival outcomes. Therefore, evaluating the TME of both the primary tumor and LNM could be beneficial for the precise use of ICIs in HNSCC. Full article
(This article belongs to the Special Issue New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition)
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19 pages, 3116 KiB  
Article
Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells
by Hong Wan, Muy-Teck Teh, Giulia Mastroianni and Usama Sharif Ahmad
Cells 2023, 12(23), 2710; https://doi.org/10.3390/cells12232710 - 26 Nov 2023
Viewed by 1215
Abstract
The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 expression. Four mRNA libraries of oral squamous carcinoma [...] Read more.
The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 expression. Four mRNA libraries of oral squamous carcinoma H413 cell lines were sequenced, and 599 candidate genes exhibited differential expression between DSG3-overexpressing and matched control lines, with 12 genes highly significantly differentially expressed, including 9 upregulated and 3 downregulated. Genes with known implications in cancer, such as MMP-13, KRT84, OLFM4, GJA1, AMOT and ADAMTS1, were strongly linked to DSG3 overexpression. Gene ontology analysis indicated that the DSG3-associated candidate gene products participate in crucial cellular processes such as junction assembly, focal adhesion, extracellular matrix formation, intermediate filament organisation and keratinocyte differentiation. Validation of RNA-Seq was performed through RT-qPCR, Western blotting and immunofluorescence analyses. Furthermore, using transmission electron microscopy, we meticulously examined desmosome morphology and revealed a slightly immature desmosome structure in DSG3-overexpressing cells compared to controls. No changes in desmosome frequency and diameter were observed between the two conditions. This study underscores intricate and multifaceted alterations associated with DSG3 in oral squamous carcinoma cells, implying a potential oncogenic role of this gene in biological processes that enable cell communication, motility and survival. Full article
(This article belongs to the Special Issue New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition)
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