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Cells
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An Advanced Approach in Male Infertility: Stem Cell Therapy
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An Advanced Approach in Male Infertility: Stem Cell Therapy

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (20 March 2023) | Viewed by 2323

Special Issue Editors

Dr. Andrea Garolla

E-Mail Website
Guest Editor
Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy
Interests: andrology; reproductive endocrinology; male infertility; assisted reproduction; sexual medicine; sperm function; sexual infectious diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Andrea Di Nisio

E-Mail Website
Guest Editor
Department of Medicine DIMED, University of Padova | UNIPD, Padova, Veneto, Italy
Interests: endocrinology; reproduction; endocrine disruptors

Special Issue Information

Dear Colleagues, 

Infertility is now considered to be a global health issue affecting approximately 15% of couples worldwide. Even after recent progress in ART, many couples are unable to parent healthy babies except through gamete donation or adoption. Infertility due to gamete deficiency resulting from genetic defects does not benefit from ART. In the past decade, research in male reproduction has seen substantial advancements in next­generation therapeutics using stem cells. Different in­vitro methods and organ models using embryonic stem cells, induced pluripotent stem cells, and glioblastoma stem cells were developed for successful production of spermatozoa. Also, autografting cryobanked spermatogonial tissue was proposed as a new strategy of fertility preservation for paediatric patients who have undergone gonadotoxic therapy.

We are pleased to invite you to submit a contribution to this special issue given your expertise in this field.

This Special Issue aims to provide an update of the potential therapeutic approaches and their impact on ART outcomes.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following: Embryonic Stem Cells (ESC), Induced Pluripotent Stem Cells (iPSC), Mesenchymal Stem Cells (MSCs), Bone Marrow Mesenchymal Stem Cells (BMSC), Spermatogonial Stem Cell (SSC) and spermatogonial tissue cryopreservation.

We look forward to receiving your contributions.

Prof. Dr. Andrea Garolla
Dr. Andrea Di Nisio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • male infertility
  • reproduction
  • cryopreservation
  • stem cells
  • induced pluripotent stem cell
  • spermatogonial stem cells
  • assisted reproduction technology

Published Papers (1 paper)

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Research

16 pages, 3208 KiB  
Article
MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility
by Cailin Wan, Wei Chen, Yinghong Cui and Zuping He
Cells 2022, 11(23), 3807; https://doi.org/10.3390/cells11233807 - 28 Nov 2022
Cited by 2 | Viewed by 1544
Abstract
Spermatogonial stem cells (SSCs) serve as a foundation for spermatogenesis and they are essential for male fertility. The fate of SSC is determined by genetic and epigenetic regulatory networks. Many molecules that regulate SSC fate determinations have been identified in mice. However, the [...] Read more.
Spermatogonial stem cells (SSCs) serve as a foundation for spermatogenesis and they are essential for male fertility. The fate of SSC is determined by genetic and epigenetic regulatory networks. Many molecules that regulate SSC fate determinations have been identified in mice. However, the molecules and signaling pathways underlying human SSCs remain largely unclear. In this study, we have demonstrated that MAP4K4 was predominantly expressed in human UCHL1-positive spermatogonia by double immunocytochemical staining. MAP4K4 knockdown inhibited proliferation of human SSCs and induced their apoptosis. Moreover, MAP4K4 silencing led to inhibition of JNK phosphorylation and MAP4K4 phosphorylation at Ser801. RNA sequencing indicated that MAP4K4 affected the transcription of SPARC, ADAM19, GPX7, GNG2, and COLA1. Interestingly, the phenotype of inhibiting JNK phosphorylation by SP600125 was similar to MAP4K4 knockdown. Notably, MAP4K4 protein was lower in the testes of patients with non-obstructive azoospermia than those with normal spermatogenesis as shown by Western blots and immunohistochemistry. Considered together, our data implicate that MAP4K4/JNK signaling pathway mediates proliferation and apoptosis of human SSCs, which provides a novel insight into molecular mechanisms governing human spermatogenesis and might offer new targets for gene therapy of male infertility. Full article
(This article belongs to the Special Issue An Advanced Approach in Male Infertility: Stem Cell Therapy)
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