Transient Receptor Potential (TRP) Ion Channels: From Development to Disease

Dear Colleagues,

This Special Issue aims to highlight the significant impact of proteins named transient receptor potential (TRP) ion channels, which have fundamentally reshaped our knowledge of the physiology and pathophysiology of living systems, from the subcellular and molecular domains to the intact organism, and their interaction with the environment. Originally, the first trp gene was identified in a Drosophila mutant with abnormal vision. However, only since the trp gene was cloned thirty years ago and the deduced amino acid sequence suggested that this gene encodes for a cation channel has TRP channel research witnessed a continuous ongoing boom with cloning and characterization of mammalian and human homologs of the Drosophila trp channel. Many of these channels are polymodal (i.e., they are activated by several distinct physical stimuli and more than one ligand). Subsequently, the scientific community recognized that TRP channel dysfunctions are not only causing several monogenic diseases in humans, but also contribute to many complex pathophysiological conditions by an array of multiple systemic or local mechanisms, which all contribute to polygenetic disease. Thus, TRP channels have emerged as promising novel therapeutic targets. Therefore, we explicitly place findings in this Cells Special Issue “Transient Receptor Potential (TRP) Ion Channels: From Development to Disease” that can be taken advantage of in creating new therapies for cardio-renal, vascular-metabolic, autoimmune, and neuronal diseases that continue to challenge our community. These include kidney diseases, hypertension, diabetes, ischemia-reperfusion injury, pain, inflammation, fibrosis, and edema, to name a few.

Prof. Dr. Maik Gollasch
Prof. Dr. Bernd Nürnberg
Guest Editors

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• TRP channels
• TRP channels cell signaling pathways
• isoform-specific functions
• regulation and function of TRP channels
• TRP channelopathies
• disease models for studying TRP channels
• TRP channels and diseases
• small-molecule inhibitors
• ageing
• geriatrics
• hypertension
• kidney