Dear Colleagues,

The term neurodegenerative disease refers to a group of neurological disorders that predominantly impact neurons in the central nervous system (CNS) that are characterized by the slow loss of neurons in the CNS, resulting in deficiencies in certain brain processes (memory, movement, and cognition). Oxidative stress, neuroinflammation, excitotoxicity, mitochondrial dysfunction, aberrant protein misfolding and aggregation, and apoptosis are some of the basic pathways linked to neurodegeneration process. Extensive research has been done trying to explain the mechanism of action and potential therapy targets for neurodegenerative disorders. As a result, neuroprotection strategies and related processes engage with the pathophysiological change to avoid and to delay the development of neurodegeneration. Herbal medicines and nutraceuticals represent an important and valuable source in the prevention, rather than the treatment, of neurological disorders. In various experimental models of neurological disorders, phytoconstituents have shown to have modulatory effects on the nervous system. 

In this Special Issue, submissions, including original research and review papers, are welcome and can cover all aspects of natural product activity on neurodegeneration and that elucidate their underlying mechanisms of action.

Potential topics include, but are not limited to, the following:

• Molecular docking experiments: receptor-ligand interaction;
• Target enzymes in neurodegenerative diseases;
• Newly synthesized compounds and optimization of natural compounds;
• Pharmacological evaluation and signaling pathways: in vitro and in vivo assays;
• The impact of natural products on neuroinflammation and neurodegeneration;
• Neurobehavioral pharmacological studies (zebrafish or rodent models).

Prof. Dr. Lucian Hritcu
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• neurodegenerative diseases
• natural products
• molecular docking
• neuroinflammation
• neurodegeneration
• signal pathways
• behavioral neuroscience