Receptor Tyrosine Kinases 2021

Dear Colleagues,

Receptor tyrosine kinases (RTKs) are a large superfamily of transmembrane receptors that play pleiotropic roles in both health and disease in cell, tissue, and organismal levels. RTKs show diversity in their extracellular ligand-binding regions, which enables their classification into 20 subfamilies. Moreover, there is a wide array of diverse ligands that can activate different RTKs, with varying selectivities and potencies. However, all RTKs have in common an intrinsic tyrosine kinase activity within their intracellular regions, which enables coupling to a variety of intracellular signalling pathways. Normal RTK function is associated with development, cell survival, growth, differentiation, cell–cell and cell–matrix interaction, and immune regulation. However, abnormal RTK activity and/or expression is a common feature in pathologies, including many cancers.

Ongoing research into RTKs covers a broad range of topics, including ligand-dependent and -independent receptor activation, receptor clustering, spatial and temporal control of RTK signalling, RTK intracellular functions, potential as entry gateways for infectious pathogens, negative regulation and recycling, and as highly attractive targets for cancer. The aim with this new, the second Special Issue of Cells, is to offer a collection of scholarly reviews and original articles that expand and update our knowledge on this important group of proteins. In this way, we hope to provide a stimulating resource for students and professionals on the breadth and impact of RTK biology. This area is sure to hold great interest across academic, industrial, and health sectors, not only for increasing our knowledge on the fundamentals of cellular biology, but also for its huge potential for translating to developments in medicine and diagnostics.

Dr. Sassan Hafizi
Guest Editor

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• receptor tyrosine kinases
• growth factor
• ligand
• signal transduction
• phosphorylation
• spatial and temporal signalling
• kinase domain
• transmembrane domain
• dimerisation
• docking protein
• development
• differentiation
• immunity
• cancer
• monoclonal antibodies
• small molecule kinase inhibitors
• tumour drug resistance
• ubiquitination
• hetero-dimerisation
• oncogene
• gene fusion
• endocytosis
• coreceptor