Luminescent Small Molecules for Biochemistry

A special issue of Colorants (ISSN 2079-6447).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2304

Special Issue Editors


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Guest Editor
Department of Chemistry, Durham University, Durham, UK
Interests: molecular photophysics; solar fuels; microscopy; bio-imaging; fluorescent probes

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Guest Editor
School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK
Interests: molecular photophysics; solar fuels; microscopy; bio-imaging; fluorescent probes

Special Issue Information

Dear Colleagues,

Bio-sensing is critical to medical diagnostics and drug design. The current state of the art techniques in microscopy improve the sensitivity and precision in the detection of analytes, and also help to probe the sub-cellular environment. Luminescent small molecules and nanoparticles (NPs) play a vital role in these developments. The uses of such molecules range from nanomachines for cancer treatment to detection of cellular distress, for example hypoxia.

This Special Issue of Colorants will highlight the range of different applications of luminescent small molecules and NPs for bio-chemical and bio-medical applications. We hope to demonstrate the breadth of potential applications of these systems and the cutting-edge science in this field, including the design, synthesis, photophysical analysis, and bio-imaging.

Dr. Patrycja Stachelek
Dr. Joshua Karlsson
Guest Editors

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Keywords

  • luminescence
  • fluorescence
  • phosphorescence
  • photodynamic therapy
  • bio-probes
  • photophysics
  • bio-sensing
  • microscopy

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Published Papers (1 paper)

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Research

22 pages, 5537 KiB  
Article
A Study on the Structure, Optical Properties and Cellular Localization of Novel 1,3-Benzothiazole-Substituted BODIPYs
by Olga Kirkilessi, Christina Arapatzi, Heribert Reis, Vassiliki Kostourou, Kyriakos C. Prousis and Theodora Calogeropoulou
Colorants 2024, 3(1), 17-38; https://doi.org/10.3390/colorants3010002 - 31 Dec 2023
Cited by 1 | Viewed by 1536
Abstract
A library of seven novel 1,3-benzothiazole-substituted BODIPY derivatives with tunable optical properties was synthesized. The new fluorescent dyes exhibited bathochromically shifted absorptions (up to 670 nm) and emissions centered in the red and near-infrared spectral region (up to 677 nm) in comparison to [...] Read more.
A library of seven novel 1,3-benzothiazole-substituted BODIPY derivatives with tunable optical properties was synthesized. The new fluorescent dyes exhibited bathochromically shifted absorptions (up to 670 nm) and emissions centered in the red and near-infrared spectral region (up to 677 nm) in comparison to the parent compound 8-phenyl BODIPY (λabs: 499 nm, λemi: 508 nm). (TD)DFT calculations were performed to rationalize the spectroscopic properties of the new dyes. The cellular biodistribution of the new BODIPY dyes, their fluorescence stability and toxicity were investigated in both living and fixed fibroblasts using time-lapse fluorescent imaging and confocal microscopy. Six of the seven new dyes were photostable and non-toxic in vitro at 10 μM concentration. In addition, they efficiently stained the cell membrane, showing diffuse and dotty localization within the cell at low concentrations (1.0 and 0.1 μM). Specifically, dye TC498 was localized in vesicular structures in both live and fixed cells and could be used as a suitable marker in co-staining studies with other commonly used fluorescent probes. Full article
(This article belongs to the Special Issue Luminescent Small Molecules for Biochemistry)
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