Advances in Endoscopy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 4946

Special Issue Editors


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Guest Editor
Gastroenterology and Endoscopy Unit, Fondazione Istituto Giuseppe Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy
Interests: gastroenterology; gastrointestinal endoscopy; irritable bowel syndrome; inflammatory bowel disease; ERCP; EUS
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Department of Gastroenterology and Gastrointestinal Endoscopy, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, 20132 Milan, Italy
Interests: operative endoscopy; luminal endoscopy; gastroparesis; post-surgical endoscopic treatment; sedation; surgical endoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The forthcoming Special Issue on advanced endoscopy aims to curate cutting-edge research within the field of gastrointestinal endoscopy. This issue invites paper submissions that focus on various facets of advanced techniques in gastrointestinal endoscopy. These encompass the endoscopic resection of pre-neoplastic and neoplastic lesions in the upper and lower gastrointestinal tract, third-space endoscopy targeting motility disorders (E-POEM for achalasia and G-POEM for gastroparesis), and endoscopic management of surgical complications, including anastomotic leaks. The Special Issue strives to advance our understanding and capabilities in the domain of advanced gastrointestinal endoscopy, with the ultimate objective of enhancing patient care and outcomes.

Dr. Emanuele Sinagra
Dr. Francesco Vito Mandarino
Guest Editors

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Published Papers (4 papers)

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Research

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9 pages, 1786 KiB  
Article
Near-Infrared On-Site Evaluation (NOSE) Examination of EBUS/EUSb Samples—A New Method for Sample Adequacy Evaluation
by Jiri Votruba, Ivan Čavarga, Tomas Bruha and Zuzana Sestakova
Diagnostics 2024, 14(17), 1887; https://doi.org/10.3390/diagnostics14171887 - 28 Aug 2024
Viewed by 427
Abstract
Fine-needle aspiration biopsy is crucial for modern diagnostics of endoscopic procedures and thus an efficient and reliable method for increasing biopsy yields is urgently needed. In our study, we address the limited availability and high price of the rapid onsite evaluation (ROSE) technique [...] Read more.
Fine-needle aspiration biopsy is crucial for modern diagnostics of endoscopic procedures and thus an efficient and reliable method for increasing biopsy yields is urgently needed. In our study, we address the limited availability and high price of the rapid onsite evaluation (ROSE) technique by introducing the technique of near-infrared on-site evaluation (NOSE) consisting of spectral measurement of near-infrared radiation (NIR) transmitted through the evaluated material. For this purpose, we designed a special optical probe consisting of two fibres, of which one is a source fibre and the second is a detector fibre. The distal ends of both fibres are brought together into one bundle which is, with the help of a special extension, applied to a cuvette with an analysed sample at a defined distance from the cuvette bottom and fixed in place. A portion of the NIR radiation received by the detector fibre after it propagates through the sample then depends on the optical and therefore morphological characteristics of the sample. Based on the measured spectral curve, we can calculate the attenuation coefficient curve and subsequently the parameter of the sample richness and the parameter characterising the autofluorescence peak as well. We found that the value of our introduced parameters is in significant relation to sample richness as well as to sample malignity. NOSE evaluation of EBUS/EUSb (endobronchial/oesophageal ultrasound bronchoscopy) specimens can be considered an easy new technique aiming to improve sampling diagnostic accuracy and to diminish costs related to the presence of a cytopathologist and related instrumentation in the endoscopy suite. Full article
(This article belongs to the Special Issue Advances in Endoscopy)
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10 pages, 1501 KiB  
Article
The Impact of Intraoperative Glucagon on the Diagnostic Accuracy of Intraoperative Cholangiogram for the Diagnosis of Choledocholithiasis: Experience from a Large Tertiary Care Center
by Nitish Mittal, Faisal S. Ali, Antonio Pizuorno Machado, Sean Ngo, Malek Shatila, Tomas DaVee, Nirav Thosani and Vaibhav Wadhwa
Diagnostics 2024, 14(13), 1405; https://doi.org/10.3390/diagnostics14131405 - 1 Jul 2024
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Abstract
A proportion of patients who undergo intraoperative cholangiogram (IOC) do not have bile duct stones at the time of endoscopic retrograde cholangiopancreatography (ERCP), either due to the spontaneous passage of stones or a false-positive IOC. Glucagon has been utilized as an inexpensive tool [...] Read more.
A proportion of patients who undergo intraoperative cholangiogram (IOC) do not have bile duct stones at the time of endoscopic retrograde cholangiopancreatography (ERCP), either due to the spontaneous passage of stones or a false-positive IOC. Glucagon has been utilized as an inexpensive tool to allow the passage of micro-choledocholithiasis to the duodenum and resolve filling defects caused by stones or air bubbles. The purpose of our study is to understand the change in diagnostic accuracy of IOC to detect choledocholithiasis with intraoperative glucagon. We conducted a retrospective study at a tertiary care center on adult patients who underwent laparoscopic cholecystectomy with IOC. The diagnostic accuracy of IOC was assessed before and after the administration of intravenous glucagon. Of 1455 patients, 374 (25.7%) received intraoperative glucagon, and 103 of these 374 patients (27.5%) showed resolution of the filling defect with the passage of contrast to the duodenum. Pre- and post-glucagon administration comparison showed enhancement in specificity from 78% to 83%, an increase in positive predictive value from 67.3% to 72.4%, and an improvement in the diagnostic accuracy of IOC from 81.5% to 84.3%. Our findings suggest that intraoperative glucagon administration carries the potential to reduce the rate of false-positive IOCs, thereby reducing the performance of unnecessary ERCPs. Full article
(This article belongs to the Special Issue Advances in Endoscopy)
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Review

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32 pages, 5799 KiB  
Review
The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders—A Comprehensive Review
by Alberto Barchi, Edoardo Vespa, Sandro Passaretti, Giuseppe Dell’Anna, Ernesto Fasulo, Mona-Rita Yacoub, Luca Albarello, Emanuele Sinagra, Luca Massimino, Federica Ungaro, Silvio Danese and Francesco Vito Mandarino
Diagnostics 2024, 14(8), 858; https://doi.org/10.3390/diagnostics14080858 - 22 Apr 2024
Cited by 2 | Viewed by 2222
Abstract
Eosinophilic Gastrointestinal Disorders (EGIDs) are a group of conditions characterized by abnormal eosinophil accumulation in the gastrointestinal tract. Among these EGIDs, Eosinophilic Esophagitis (EoE) is the most well documented, while less is known about Eosinophilic Gastritis (EoG), Eosinophilic Enteritis (EoN), and Eosinophilic Colitis [...] Read more.
Eosinophilic Gastrointestinal Disorders (EGIDs) are a group of conditions characterized by abnormal eosinophil accumulation in the gastrointestinal tract. Among these EGIDs, Eosinophilic Esophagitis (EoE) is the most well documented, while less is known about Eosinophilic Gastritis (EoG), Eosinophilic Enteritis (EoN), and Eosinophilic Colitis (EoC). The role of endoscopy in EGIDs is pivotal, with applications in diagnosis, disease monitoring, and therapeutic intervention. In EoE, the endoscopic reference score (EREFS) has been shown to be accurate in raising diagnostic suspicion and effective in monitoring therapeutic responses. Additionally, endoscopic dilation is the first-line treatment for esophageal strictures. For EoG and EoN, while the literature is more limited, common endoscopic findings include erythema, nodules, and ulcerations. Histology remains the gold standard for diagnosing EGIDs, as it quantifies eosinophilic infiltration. In recent years, there have been significant advancements in the histological understanding of EoE, leading to the development of diagnostic scores and the identification of specific microscopic features associated with the disease. However, for EoG, EoN, and EoC, precise eosinophil count thresholds for diagnosis have not yet been established. This review aims to elucidate the role of endoscopy and histology in the diagnosis and management of the three main EGIDs and to analyze their strengths and limitations, their interconnection, and future research directions. Full article
(This article belongs to the Special Issue Advances in Endoscopy)
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Other

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4 pages, 2461 KiB  
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Endoscopic Retrograde Cholangiopancreatography (ERCP) for Suspected Mirizzi Syndrome Type IV as Both a Diagnostic and Bridge-to-Surgery Procedure
by Giacomo Emanuele Maria Rizzo, Settimo Caruso and Ilaria Tarantino
Diagnostics 2024, 14(8), 855; https://doi.org/10.3390/diagnostics14080855 - 22 Apr 2024
Viewed by 985
Abstract
Mirizzi syndrome (MS) is a challenging diagnosis due to its similar presentation with other biliary diseases; thus, the role of endoscopy is sometimes unclear, especially in altered anatomy. Radiological examinations may usually suspect it, but deeper examinations could be necessary to confirm it. [...] Read more.
Mirizzi syndrome (MS) is a challenging diagnosis due to its similar presentation with other biliary diseases; thus, the role of endoscopy is sometimes unclear, especially in altered anatomy. Radiological examinations may usually suspect it, but deeper examinations could be necessary to confirm it. Endoscopic retrograde cholangiopancreatography (ERCP) certainly has a therapeutic role in cases of jaundice, cholangitis or concurrent choledocolithiasis, although surgery is without doubt the definitive treatment in most of the cases. Therefore, surgeons may have a clearer picture of the condition of the biliary tree with respect to fistulas thanks to ERCP, particularly in patients with a higher grade of MS (type higher than 2 in the Csendes classification). Therefore, a complete removal of biliary stones is sometimes not possible due to size and location, so biliary stenting becomes the only option, even if transitory. Our brief report is a further demonstration of the fundamental role of ERCP in managing MS, even when it has no long-term therapeutic aim but is performed as bridge-to-surgery, especially in cases with a more difficult biliary anatomy due to the type of fistula. Moreover, we truly suggest discussing patients affected with MS in a multidisciplinary board, preferably in tertiary hepatobiliary centers. Full article
(This article belongs to the Special Issue Advances in Endoscopy)
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