Dear Colleagues,

This Special Issue of Diagnostics will be devoted to the latest advances in chronic kidney disease (CKD) diagnostics.

CKD in different stages affects approximately 12% of the world's population. Nowadays, diabetes and hypertension are among the leading causes of CKD.

Due to the constant increase in the total number of diabetic patients, the incidence of CKD caused by diabetic nephropathy and subsequently the number of patients with end-stage renal disease (ESRD) is expected to rise. Early diagnosis and treatment of diabetic nephropathy may have a crucial impact on disease progression.

Glomerulonephritis (GN) is, next to hypertension and diabetes, one of the leading causes of CKD. Both nephrotic and nephritic syndromes are clinical conditions, requiring extensive diagnostic workup, including laboratory tests, imaging studies and eventually renal biopsy, with additional tests and specialized stains. In many GN patients, electron microscopy and genotyping might be crucial to achieve final diagnosis. Innovative IT tools are increasingly used in clinical settings. For example, artificial intelligence (AI) may help with precise diagnosis due to its ability to combine multiple clinical and laboratory data.

Acute kidney injury (AKI) is frequently observed in elderly patients, following surgical and radiological procedures, involving the administration of radiocontrast, with potential progression to CKD. Urinary biochemical markers may be helpful in predicting the development and severity of AKI. Point of care testing methods are increasingly used in nephrology patients with unstable clinical conditions, but also to assess CKD complications including electrolyte and acid–base disorders.

Hemodialysis (HD) is a one of the main forms of renal replacement therapy (RTT) in ESRD. Anemia, electrolyte disturbances, metabolic bone disease and both dialysis fistula and catheter dysfunction are the basic HD complications requiring appropriate diagnostic tools. More and more uremic toxins are being discovered in patients with ESRD, which influence the prognosis of dialysis patients.

We invite scientists to submit articles presenting new achievements in chronic kidney disease. We look forward to your submission.

Dr. Tomasz Gołębiowski
Dr. Andrzej Konieczny
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• chronic kidney disease
• diabetic nephropathy
• glomerulonephritis
• acid–base disorders
• uremic toxin
• artificial intelligence
• metabolic bone disease
• vascular access
• arteriovenous fistula
• catheter
• hemodialysis