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Diagnostics
Special Issues
Diagnosis and Management of Heart Disease in Aging
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Diagnosis and Management of Heart Disease in Aging

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1887

Special Issue Editor

Dr. Ji Li

E-Mail Website
Guest Editor
Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Interests: AMPK signal transduction; ischemia and reperfusion; heart failure; energy metabolism; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The ability of the myocardium to tolerate pathological stress becomes compromised with aging and individuals are more susceptible to adverse outcomes associated with coronary artery disease. It is critical to elucidate THE molecular and physiological mechanisms by which age-related vascular homeostasis is altered with aging in order to improve therapeutic strategies for the elderly. Accumulating evidence suggests that there is an age-related impairment that is postulated to be a mechanism for a decline in stress tolerance observed with aging. In addition, significant progress has been made by demonstrating that metabolic homeostasis and the inflammatory response play key roles in age-related heart diseases. Identifying good diagnostic markers of cardiovascular disease is an umet need in the cardiovascular research field to prevent, delay or reverse age-related heart diseases. This Special Issue focuses on manuscripts related to the diagnosis and management of cardiovascular diseases. This Special Issue of Diagnostics welcomes all related research and review articles associated with cardiovascular disease in aging to be considered for publication in this Special Issue.

Dr. Ji Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • cardiovascular impairment
  • neurodegenerative disease
  • metabolic homeostasis
  • inflammatory response
  • diagnosis

Published Papers (1 paper)

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Review

11 pages, 1634 KiB  
Review
Sestrin2 as a Potential Target in Hypertension
by Steven Didik, Hao Wang, Adewale Segun James, Lily Slotabec and Ji Li
Diagnostics 2023, 13(14), 2374; https://doi.org/10.3390/diagnostics13142374 - 14 Jul 2023
Viewed by 1427
Abstract
Hypertension is a highly complex, intricate condition affecting millions of individuals across the globe. Nearly half of adults in the United States are diagnosed with hypertension, with incident rates projected to rise over the next decade. Hypertension is a precursor to many cardiovascular [...] Read more.
Hypertension is a highly complex, intricate condition affecting millions of individuals across the globe. Nearly half of adults in the United States are diagnosed with hypertension, with incident rates projected to rise over the next decade. Hypertension is a precursor to many cardiovascular diseases including atherosclerosis, stroke, myocardial infarction, heart failure, and peripheral artery disease. This review describes the major processes contributing to the development of hypertension and how Sestrin2 (Sesn2), an antioxidative protein, could be a potential target in the treatment of hypertension. In hypertension, increased reactive oxygen species (ROS) production is a critical component in the etiology of the condition. The increased ROS in hypertension is derived from a variety of sources, all of which are covered in depth in this review. Increased ROS is generated from mitochondrial stress, endoplasmic reticulum (ER) stress, NADPH oxidase (NOX) overactivity, and the uncoupling of endothelial nitric oxidase synthase (eNOS). Sesn2, a highly conserved, stress-inducible protein, has the structural and functional characteristics to be a potential therapeutic target to alleviate the progression of hypertension. The structure, function, genetics, and characteristics of Sesn2 are presented in the review. The Nrf2/Sesn2, Sesn2/AMPK/mTOR, and Sesn2/Angiotensin II signaling pathways are described in detail in this review. Sesn2 can be utilized in a multitude of ways as a therapeutic modality in hypertension. This review explores potential Sesn2 inducers and activators and how Sesn2 can be incorporated into gene therapy for the treatment of hypertension. Full article
(This article belongs to the Special Issue Diagnosis and Management of Heart Disease in Aging)
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