Special Issue "Appetite Regulation and Mitophagy with Links to Chronic Disease and Alzheimer’s Disease"

A special issue of Diseases (ISSN 2079-9721).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Dr. Ian James Martins

Centre of Excellence in Alzheimer’s Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Australia
Website | E-Mail
Interests: Alzheimer's Disease; appetite regulation; environment; nutrition; senescence; accelerated disease; metabolism; type 3 diabetes; heat shock gene; mitochondrial biogenesis; autoimmune disease

Special Issue Information

Dear Colleagues,

Nutritional research has become important in appetite regulation with improvements in health relevant to healthy diets and the prevention of chronic disease and Alzheimer’s disease. Environmental factors such as stress, anxiety, and depression are important to consider with relevance to appetite dysregulation and the global increase in chronic diseases such as diabetes and neurodegenerative diseases. The origins of metabolic diseases may involve the dysregulation of hormones, nuclear receptors, and neuropeptides in the brain and peripheral tissues. Appetite disorders and brain metabolic diseases associated with obesity and diabetes require early intervention with diet, lifestyle, and drug therapy to prevent non-alcoholic fatty liver disease (NAFLD) and Alzheimer’s disease. The effects of overnutrition on appetite and core body temperature regulation induce autoimmune disease and mitophagy that are involved in programmed cell death in insulin resistance and Alzheimer’s disease. Nutritional research is now essential to promote mitochondrial biogenesis that is connected to appetite regulation in both chronic and neurodegenerative diseases. The links between appetite dysregulation, endocrinology, and metabolism implicate the peptide apelin and the nuclear receptor Sirtuin 1 (Sirt 1) to be defective and involved in NAFLD and Alzheimer’s disease. Appetite regulation is now critical to the prevention of brain disorder therapy that may involve the reversal of synaptic plasticity defects that link diabetes to neurodegenerative diseases.

Dr. Ian James Martins
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diseases is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-aging genes
  • Alzheimer’s disease
  • appetite
  • diabetes
  • nutrition
  • mitophagy
  • synaptic plasticity
  • NAFLD
  • autoimmune disease
  • stress
  • global
  • chronic diseases

Published Papers (1 paper)

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Review

Open AccessFeature PaperReview Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia
Received: 17 June 2018 / Revised: 17 July 2018 / Accepted: 19 July 2018 / Published: 20 July 2018
PDF Full-text (725 KB) | HTML Full-text | XML Full-text
Abstract
Feeding and nutrition follow the growth trajectory of the course of life. The profound physiological changes that human body experiences during ageing affect separate aspects of food intake, from tastant perception to satiety. Concurrent morbidities, such as neurodegeneration, as seen in dementia, and
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Feeding and nutrition follow the growth trajectory of the course of life. The profound physiological changes that human body experiences during ageing affect separate aspects of food intake, from tastant perception to satiety. Concurrent morbidities, such as neurodegeneration, as seen in dementia, and metabolic syndrome, may further shape nutritional behaviours, status and adequacy. In an effort to fill the gap between the exhausting basic research and the actual needs of professionals caring for the exponentially expanding ageing population, the current review addresses major factors relevant to appetite and eating disturbances. Does age alter the perception of food modalities? Is food generally still perceived as alluring and delicious with age? Is there an interplay between ageing, cognitive decline, and malnutrition? What tools can we adopt for proper and timely monitoring? Finally, what anatomical and pathophysiological evidence exists to support a hypothesis of central regulation of metabolic perturbations in normal and accelerated cognitive impairment, and how can we benefit from it in health practice? Full article
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