Special Issue "Targeting Epigenetics in Human Health and Diseases: From Mechanisms to Therapeutics and Beyond"
A special issue of Diseases (ISSN 2079-9721).
Deadline for manuscript submissions: closed (30 December 2016)
Dr. Takeo Kubota
Past Professor, Department of Epigenetic Medicine, University of Yamanashi, Yamanashi 409-3898, Japan Present affiliation, Supervising Doctor, Kofu Office, Yamanashi Prefecture Red Cross Blood Center, Japanese Red Cross Society, 1-6-1 Ikeda, Kofu-city, Yamanashi, 400-0062, Japan
Interests: neurodevelopmental disorder; epigenome; environmental stress; epigenetic reversibility; preemptive medicine
Epigenetics is a gene regulation mechanism that does not depend on genome (genomic DNA sequences) but depends on the epigenome (chemical modification of genomic DNA and histone proteins).
Recent studies indicate that epigenomic abnormalities, not only cause congenital diseases, but also cause acquired diseases, such as psychiatric diseases and type 2 diabetes, since the epigenome is more vulnerable to environmental stress than the genome.
Therefore, understanding of how the epigenome reacts to environmental stress and how we maintain the normal epigenome has become an important medical issue.
Since the epigenome has a reversible property, which is based on removable residues on genomic DNA, environmentally induced epigenomic alterations can be restored. In fact, some drugs, especially those for psychiatric diseases, are known to restore an altered epigenome, resulting in correction of gene expression.
In this Special Issue, I would like to focus on basic or clinical studies that contribute to human health and preemptive medicine through identification of the epigenomic markers or development of the epigenetic therapy.
Dr. Takeo Kubota
Manuscript Submission Information
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- preemptive medicine