Biopolymer Gels as Smart Drug Delivery and Theranostic Systems

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 1461

Special Issue Editors


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Guest Editor
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea
Interests: polymeric hydrogels; drug delivery; biomaterials; polymer synthesis; polymeric nanocomposites

E-Mail Website
Guest Editor
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea
Interests: polymers; energy; bio-medical
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biopolymers are a class of polymers generated from plants and animals that perform a wide range of functions. In recent years, biopolymer-hydrogel-based research has grown in importance, drawing significant attention in the field of polymer chemistry regarding its prospective use for drug delivery platforms and theranostic applications. Biocompatibility and biodegradability are crucial requirements for biomedical applications. Biopolymeric hydrogels are gaining popularity in healthcare and biotechnology fields. Biopolymer hydrogels are extensively utilized in the biomedical industry because of their physical resemblance to natural tissues. They are particularly useful in the administration of drug, theranostic, and tissue engineering applications. The swelling capacity of biopolymer-based hydrogels is especially appealing since it allows them to absorb and retain a substantial amount of water and biological media, rendering them an ideal choice for use in administering drugs and theranostic applications. Furthermore, the hydrogels' unique porous network structure allows for optimized drug loading and controlled release characteristics under certain biological stimulation settings to improve theranostic efficiency.

This Special Issue theme focuses on the advancement of biopolymer-based hydrogel technology, highlighting its accomplishments in various fields such as drug delivery and theranostics, as well as emphasizing new challenges and opportunities. The research community is invited to submit original research articles, communications, and review papers on emerging strategies in the design, development, and applications of biopolymer-based hydrogel materials in a wide range of fields, including drug delivery, theranostics, and other relevant biomedical fields.

Dr. Madhappan Santhamoorthy
Prof. Dr. Seongcheol Kim
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymers
  • hydrogels
  • drug delivery
  • stimuli responsive
  • self-assembly
  • biopolymeric hydrogels
  • tissue engineering
  • wound dressing
  • multifunctional hydrogels
  • cancer therapy
  • tissue engineering
  • soft materials
  • composite hydrogels
  • theranostics
  • micro/nanogels

Published Papers (1 paper)

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Research

14 pages, 3868 KiB  
Article
pNIPAm-Based pH and Thermoresponsive Copolymer Hydrogel for Hydrophobic and Hydrophilic Drug Delivery
by Anandhu Mohan, Madhappan Santhamoorthy, Thi Tuong Vy Phan and Seong-Cheol Kim
Gels 2024, 10(3), 184; https://doi.org/10.3390/gels10030184 - 07 Mar 2024
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Abstract
The regulated and targeted administration of hydrophobic and hydrophilic drugs is both promising and challenging in the field of drug delivery. Developing a hydrogel which is responsive to dual stimuli is considered a promising and exciting research area of study. In this work, [...] Read more.
The regulated and targeted administration of hydrophobic and hydrophilic drugs is both promising and challenging in the field of drug delivery. Developing a hydrogel which is responsive to dual stimuli is considered a promising and exciting research area of study. In this work, melamine functionalized poly-N-isopropyl acrylamide-co-glycidyl methacrylate copolymer has been developed by copolymerizing glycidyl methacrylate (GMA) monomer with N-isopropyl acrylamide (NIPAm) and further functionalized with melamine units (pNIPAm-co-pGMA-Mela). The prepared pNIPAm-co-pGMA-Mela copolymer hydrogel was characterized using various characterization techniques, including 1H NMR, FTIR, SEM, zeta potential, and particle size analysis. A hydrophobic drug (ibuprofen, Ibu) and hydrophilic drug (5-fluorouracil, 5-Fu) were selected as model drugs. Dual pH and temperature stimuli-responsive drug release behavior of the pNIPAm-co-pGMA-Mela hydrogel was evaluated under different pH (pH 7.4 and 4.0) and temperature (25 °C, 37 °C, and 45 °C) conditions. Furthermore, the in vitro biocompatibility of the developed pNIPAm-co-pGMA-Mela copolymer hydrogel was determined on MDA-MB-231 cells. The pH and temperature-responsive drug delivery study results reveal that the pNIPAm-co-pGMA-Mela hydrogel system is responsive to both pH and temperature stimuli and exhibits about ~100% of Ibu and 5-Fu, respectively, released at pH 4.0/45 °C. Moreover, the MTT assay and hemocompatibility analysis results proved that the pNIPAm-co-pGMA-Mela hydrogel system is biocompatible and hemocompatible, suggesting that that it could be used for drug delivery applications. The experimental results suggest that the proposed pNIPAm-co-pGMA-Mela hydrogel system is responsive to dual pH and temperature stimuli, and could be a promising drug carrier system for both hydrophilic and hydrophobic drug delivery applications. Full article
(This article belongs to the Special Issue Biopolymer Gels as Smart Drug Delivery and Theranostic Systems)
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