Functional Genomics of Host-Microbiome-Mediated Disease Resistance in Livestock

Dear Colleagues,

Porcine reproductive and respiratory syndrome (PRRS) has become one of the most important pig diseases that causes significant economic losses worldwide. The causative agent, PRRS virus (PRRSV), is an enveloped single-stranded positive-sense RNA virus with a high mutation rate. This disease is characterized by severe reproductive failure in sows and respiratory issues such as interstitial pneumonia in pigs of all ages, especially piglets. At present, commercial vaccines are available and valuable but are limited, since PRRS vaccine is a double-edged sword. Thus, vaccination is highly controversial. The pathogenesis of PRRSV and the interactions of the virus with host cells remain unclear and require further study. This Special Issue aims to gather a collection of review or original research articles on PRRSV including i) host–pathogen interactions; ii) PRRSV resistance by the gene-editing technique; iii) immune escape in the life cycle of the virus; iv) antiviral development against PRRSV; v) PRRSV resistance gene discovery and utilization.

Dr. Chunhe Guo
Guest Editor

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• PRRSV
• host–pathogen interactions
• resistance