Genetics of Diabetes

Dear Colleagues,

Genetic studies, including genome-wide linkage and association studies, have been a main component of research strategies aiming at understanding the pathogenesis of various forms of diabetes. Type 1 and type 2 diabetes benefited from consortia screening large cohorts using various polymorphisms (microsatellites, SNPs and CNVs), from common to rare. For other “specific” forms of diabetes (neonatal, syndromic or atypical), characterization of homogeneous phenotypes through linkage was crucial. However, despite intensive studies, the identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. The achievement of next-generation-sequencing technologies applied to the search for DNA variants or aiming at characterizing functional elements, as examplified by the recent ENCODE project, opens a promising era to decipher the genetic bases of diabetes, to help better understand pathogenetic mechanisms, hopefully leading to personalized medicine.
This Special Issue of “Genes” welcomes reviews and original papers covering recent genetic research on any type of diabetes, either multifactorial or monogenic, both in man and in animal models, using high-throughput omic approaches. Special interest will be given to integrative biology studies.

Dr. Claire Vandiedonck
Guest Editor

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