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Molecular Research on Reproductive Toxicology
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Molecular Research on Reproductive Toxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1712

Special Issue Editor

Dr. Chiara Maria Motta

E-Mail Website
Guest Editor
Department of Biology, University Federico II, Via Cintia 21, 80126 Napoli, Italy
Interests: emerging contaminants; environmental toxicity; benzodiazepines; gametogenesis; embryo development; teratogenicity; oxidative stress; gene expression; behavioral alterations; histological alterations

Special Issue Information

Dear Colleagues,

Drug contamination of superficial waters represents an emerging problem of great concern. For many decades, pharmaceutical products have been discarded in the sewage as waste or metabolites, with no concern for the effects these might have exerted on wild flora and fauna.

This Special Issue intends to collect the most recent evidence about the interferences that broader-use pharmacological products are causing on the reproduction of aquatic organisms. Of particular interest are psychotropic drugs, the use of which is closely related to our stressful life and has significantly increased due to the COVID pandemic.

This Special Issue will accept articles dealing with interferences on reproductive behavior, gametogenesis, fertilization, and development with a particular emphasis on the underlying molecular mechanisms.

Studies on invertebrate and low vertebrate species, usually neglected, are particularly welcome. In order to allow for a comparison among different model species, updated reviews on the effects on mammalian reproduction, including humans, are also welcome, as well as clinical submissions with biomolecular experiments.

This Special Issue is supervised by Dr. Chiara Maria Motta and assisted by Dr. Chiara Fogliano (University Federico II).

Dr. Chiara Maria Motta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental contamination
  • aquatic organisms
  • psychotropic drugs
  • gametogenesis
  • development
  • teratogenesis
  • gene expression
  • behavioral effects
  • oxidative stress
  • epigenotoxic effects
  • detoxification
  • bioaccumulation

Published Papers (2 papers)

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16 pages, 5422 KiB  
Article
Benzodiazepine Interference with Fertility and Embryo Development: A Preliminary Survey in the Sea Urchin Paracentrotus lividus
by Chiara Fogliano, Rosa Carotenuto, Paola Cirino, Raffaele Panzuto, Martina Ciaravolo, Palma Simoniello, Ilaria Sgariglia, Chiara Maria Motta and Bice Avallone
Int. J. Mol. Sci. 2024, 25(4), 1969; https://doi.org/10.3390/ijms25041969 - 06 Feb 2024
Viewed by 644
Abstract
Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large and constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In the last decades, evidence has been [...] Read more.
Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large and constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In the last decades, evidence has been collected on the possible interference of benzodiazepines with reproductive processes, but data are few and incomplete. In this study, the possible negative influence of delorazepam on fertilization and embryo development has been tested in Paracentrotus lividus, a key model organism in studies of reproduction and embryonic development. Sperm, eggs, or fertilized eggs have been exposed to delorazepam at three concentrations: 1 μg/L (environmentally realistic), 5 μg/L, and 10 μg/L. Results indicate that delorazepam reduces the fertilizing capacity of male and female gametes and interferes with fertilization and embryo development. Exposure causes anatomical anomalies in plutei, accelerates/delays development, and alters the presence and distribution of glycoconjugates such as N-Acetyl-glucosamine, α-linked fucose, and α-linked mannose in both morulae and plutei. These results should attract attention to the reproductive fitness of aquatic species exposed to benzodiazepines and pave the way for further investigation of the effects they may exert on human fertility. The presence of benzodiazepines in the aquatic environment raises concerns about the reproductive well-being of aquatic species. Additionally, it prompts worries regarding potential impacts on human fertility due to the excessive use of anxiolytics. Full article
(This article belongs to the Special Issue Molecular Research on Reproductive Toxicology)
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14 pages, 3090 KiB  
Article
Perfluorooctanoic Acid (PFOA) Exposure Compromises Fertility by Affecting Ovarian and Oocyte Development
by Han Zhang, Lulu Han, Lijun Qiu, Bo Zhao, Yang Gao, Zhangjie Chu and Xiaoxin Dai
Int. J. Mol. Sci. 2024, 25(1), 136; https://doi.org/10.3390/ijms25010136 - 21 Dec 2023
Viewed by 637
Abstract
PFOA, a newly emerging persistent organic pollutant, is widely present in various environmental media. Previous reports have proved that PFOA exposure can accumulate in the ovary and lead to reproductive toxicity in pregnant mice. However, the potential mechanism of PFOA exposure on fertility [...] Read more.
PFOA, a newly emerging persistent organic pollutant, is widely present in various environmental media. Previous reports have proved that PFOA exposure can accumulate in the ovary and lead to reproductive toxicity in pregnant mice. However, the potential mechanism of PFOA exposure on fertility remains unclear. In this study, we explore how PFOA compromises fertility in the zebrafish. The data show that PFOA (100 mg/L for 15 days) exposure significantly impaired fertilization and hatching capability. Based on tissue sections, we found that PFOA exposure led to ovarian damage and a decrease in the percentage of mature oocytes. Moreover, through in vitro incubation, we determined that PFOA inhibits oocyte development. We also sequenced the transcriptome of the ovary of female zebrafish and a total of 284 overlapping DEGs were obtained. Functional enrichment analysis showed that 284 overlapping DEGs function mainly in complement and coagulation cascades signaling pathways. In addition, we identified genes that may be associated with immunity, such as LOC108191474 and ZGC:173837. We found that exposure to PFOA can cause an inflammatory response that can lead to ovarian damage and delayed oocyte development. Full article
(This article belongs to the Special Issue Molecular Research on Reproductive Toxicology)
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