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New Cellular and Molecular Insights into Glaucoma
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New Cellular and Molecular Insights into Glaucoma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 25 August 2024 | Viewed by 543

Special Issue Editors

Dr. Meritxell López-Gallardo

E-Mail Website
Guest Editor
Departamento de Fisiología, Facultad de Medicina, Grupo UCM 951579, Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: neurophysioly; central nervous system; neuronal and glial cells; neuroinflammation; therapeutical approaches
Dr. José A. Fernández-Albarral

E-Mail Website
Guest Editor
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: neurophysioly; central nervous system; neuronal and glial cells; neuroinflammation; therapeutical approaches
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss of retinal ganglion cells (RGCs). Glaucomatous pathology causes are diverse, but many have been shown to induce a neuroinflammatory process that triggers cellular damage. Inflammation is mediated by the activation of retinal microglial and macroglial cells (astrocytes and Müller cells), but much remains unknown about the cellular and molecular mechanisms underlying the ultimate death of RGCs. Deepening our knowledge of these mechanisms is the basis for seeking new therapeutic strategies for their treatment and attenuating the consequences of glaucoma in patients. The Special Issue on glaucoma highlights the latest advancements in cellular and molecular research, which is the basis for the translation of research insights into clinical strategies.

Dr. Meritxell López-Gallardo
Dr. José A. Fernández-Albarral
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroinflammation
  • microglia
  • macroglia
  • retinal ganglion cells
  • therapeutical approaches

Published Papers (1 paper)

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Research

13 pages, 1892 KiB  
Article
Profile of Lipoprotein Subclasses in Chinese Primary Open-Angle Glaucoma Patients
by Changzhen Fu, Jianming Xu, Shao-Lang Chen, Chong-Bo Chen, Jia-Jian Liang, Zibo Liu, Chukai Huang, Zhenggen Wu, Tsz Kin Ng, Mingzhi Zhang and Qingping Liu
Int. J. Mol. Sci. 2024, 25(8), 4544; https://doi.org/10.3390/ijms25084544 - 21 Apr 2024
Viewed by 380
Abstract
To investigate the plasma lipoprotein subclasses in patients with primary open-angle glaucoma (POAG), a total of 20 Chinese POAG patients on intraocular pressure (IOP)-lowering treatment and 20 age-matched control subjects were recruited. Based on the levels of total cholesterol (TC) and low-density lipoprotein [...] Read more.
To investigate the plasma lipoprotein subclasses in patients with primary open-angle glaucoma (POAG), a total of 20 Chinese POAG patients on intraocular pressure (IOP)-lowering treatment and 20 age-matched control subjects were recruited. Based on the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), the study subjects were divided into elevated- and normal-level subgroups. The plasma lipoprotein, lipoprotein subclasses, and oxidized LDL (oxLDL) levels were quantitatively measured. The discrimination potential of the lipoproteins was evaluated using the area under the receiver operating characteristic curve (AUC), and their correlation with clinical parameters was also evaluated. Compared to the control subjects with elevated TC and/or LDL-C levels, the levels of TC, LDL-C, non-high-density lipoprotein cholesterol (non-HDL), LDL subclass LDL3 and small dense LDL (sdLDL), and oxLDL were significantly higher in POAG patients with elevated TC and/or LDL-C levels. No differences in any lipoproteins or the subclasses were found between the POAG patients and control subjects with normal TC and LDL-C levels. Moderate-to-good performance of TC, LDL-C, non-HDL, LDL3, sdLDL, and oxLDL was found in discriminating between the POAG patients and control subjects with elevated TC and/or LDL-C levels (AUC: 0.710–0.950). Significant negative correlations between LDL3 and sdLDL with retinal nerve fiber layer (RNFL) thickness in the superior quadrant and between LDL3 and average RNFL thickness were observed in POAG patients with elevated TC and/or LDL-C levels. This study revealed a significant elevation of plasma lipoproteins, especially the LDL subclasses, in POAG patients with elevated TC and/or LDL-C levels, providing insights on monitoring specific lipoproteins in POAG patients with elevated TC and/or LDL-C. Full article
(This article belongs to the Special Issue New Cellular and Molecular Insights into Glaucoma)
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