Osteosarcoma: Current Advances from Molecular and Cellular Mechanisms to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 6497
Special Issue Editors
Interests: cancer; molecular genetics; osteosarcoma; cancer biomarkers
Interests: bone cell biology and oncology; bone tissue engineering and regenerative medicine; exosome-mediated communication in bone pathophysiology
Special Issue Information
Dear Colleagues,
Osteosarcoma is a rare aggressive primary bone cancer with the highest incidence in children and young adults between 10 and 30 years of age. Standard treatment for osteosarcoma is surgery and neoadjuvant/adjuvant chemotherapy, which is quite effective in localized disease. The prognosis for recurrent or metastatic osteosarcoma is poor and treatment may include targeted therapies with kinase inhibitors or mTOR inhibitors.
Osteosarcoma arises from mesenchymal-stem-cell-derived osteoblast precursor cells. The tumors are highly heterogeneous with complex genomic landscape involving numerous structural and copy number alterations. Alterations in TP53 are the most frequently somatic changes, while pathogenic germline mutations in RB1, TP53, RECQL4, BLM, and WRN are associated with an increased risk of osteosarcoma. Tumor heterogeneity and a lack of recurrent driver mutations make it difficult to identify effective molecularly targeted therapies. Recent multi-omics studies have enhanced our understanding of the molecular pathways in osteosarcoma pathogenesis and are opening up new opportunities for biomarker-driven precision therapies based on molecular subtypes or altered genomic or cellular pathways such as PI3K-ATK-mTOR signaling, homologous recombination repair pathway, or therapies based on the immune profile/response of tumors. This Special Issue will compile recent research on various cellular and molecular processes involved in osteosarcoma growth, progression, and drug sensitivity/resistance, which could lead to the identification of new drug targets or therapies and improvements in osteosarcoma treatment.
Dr. Virinder Kaur Sarhadi
Dr. Francesca Perut
Guest Editors
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Keywords
- osteosarcoma
- cell signalling
- molecular pathways
- transcriptome
- epigenetics
- genomics
- drug targets
- therapy
- drug resistance
- targeted therapy
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