Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment

Dear Colleagues,

We are editing a Special Issue for the International Journal of Molecular Science on "Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment". We would like to invite you to contribute a research article or review article in an area related to this topic.

Acute inflammation is a response to a pathogen or a physical or chemical insult that aims to eliminate the source of the damage and restore homeostasis. In the physiological context, after tissue repair or pathogen elimination, the inflammation is reduced and the homeostatic state recovered. However, if inflammation is unregulated, it can become chronic, inducing malignant cell transformation in the surrounding tissue. It is widely accepted that inadequately resolved chronic inflammation is closely linked to cancer development, more so in the gastrointestinal tract and liver than in any other organs. Some examples include Barrett’s esophagitis being a risk factor for esophageal cancer, Helicobacter pylori (H. pylori) infection for the development of gastric cancer and MALT lymphoma, chronic inflammatory bowel diseases for colorectal cancer development, and chronic viral hepatitis infection for the development of liver cancer. Inflammation-driven malignancies can result from the complex crosstalk between cytokines, chemokines, growth factors and reactive oxygen species (ROS) generated by inflammatory cells and injured parenchymal cells.

Despite a clear causal relationship between inflammation and cancers in the gastrointestinal tract, further studies of the underlying mechanisms and signaling pathways regulated by chronic inflammation activators and inhibitors responsible for this interaction are not fully established.

We aim to develop this Special Issue to contribute and share updates on the advancements in this field.

Themes and questions that we want to address in this Special Issue include, but are not limited to:

• Biomarker discovery
• Pathogenesis of GI cancer
• Omics approach to IBD and GI cancer
• New treatment strategies
• The natural history of chronic inflammation in IBD
• The natural history of chronic inflammation towards GI cancer
• Risk factors of IBD and GI Cancer
• Early diagnosis

Dr. Laura Francesca Pisani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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