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Life
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New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal...
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New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 5605

Special Issue Editor

Dr. Laura Francesca Pisani

E-Mail Website
Guest Editor
Cellular and Molecular Immunology Lab, Department of Biotechnology and Biosciences, Univesità degli studi Milano – Bicocca, Piazza della Scienza, 2, 20126 Milano, Italy
Interests: chronic inflammation in inflammatory bowel disease and gastric cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute inflammation is a response to a pathogen or a physical or chemical insult that aims to eliminate the source of the damage and restore homeostasis. In the physiological context, after tissue repair or pathogen elimination, the inflammation is resolved and the homeostatic state recovered. However, unregulated inflammation can become chronic, inducing malignant cell transformation in the surrounding tissue. It is widely accepted that inadequately resolved chronic inflammation is closely linked to cancer development more in the gastrointestinal tract and liver than in any other organs. Examples include Barrett’s esophagitis being a risk factor for esophageal cancer, Helicobacter pylori (H. pylori) infection for gastric cancer and MALT lymphoma, chronic inflammatory bowel diseases for colorectal cancer, and chronic viral hepatitis infection for liver cancer. Inflammation-driven malignancies can result from the complex crosstalk between cytokines, chemokines, growth factors, and reactive oxygen species (ROS) generated by inflammatory cells and injured parenchymal cells.

Despite the clear causal relationship between inflammation and cancers in the gastrointestinal tract, further studies underlying mechanisms and signaling pathways regulated by chronic inflammation activators and inhibitors responsible for this interaction are lacking.

This calls for a focused issue on “New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer” to not only advance knowledge in this field but also evaluate patient outcomes. This Special Issue aims contribute to and communicate advancements in this field.

Themes and questions that we want to address in this Special Issue include, but are not limited to:

  • Biomarker discovery;
  • Pathogenesis of GI cancer;
  • Omics approach to IBD and GI cancer;
  • New treatment strategies;
  • The natural history of chronic inflammation in IBD;
  • The natural history of chronic inflammation towards GI cancer;
  • Risk factors of IBD and GI cancer;
  • Early diagnosis.

Dr. Laura Francesca Pisani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarker discovery
  • pathogenesis of GI cancer
  • omics approach to IBD and GI cancer
  • new treatment strategies
  • the natural history of chronic inflammation in IBD
  • the natural history of chronic inflammation towards GI cancer
  • risk factors of IBD and GI cancer
  • early diagnosis

Published Papers (3 papers)

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Research

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16 pages, 3781 KiB  
Article
An Analysis of the Content of Metalloproteinases in the Intestinal Wall of Patients with Crohn’s Disease
by Grzegorz Chrzanowski, Grzegorz Pasternak, David Aebisher, Klaudia Dynarowicz, Angelika Myśliwiec, Dorota Bartusik-Aebisher, Barbara Sosna, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka and Rafał Filip
Life 2023, 13(10), 2013; https://doi.org/10.3390/life13102013 - 5 Oct 2023
Cited by 1 | Viewed by 746
Abstract
One of the inflammatory bowel diseases is Crohn’s disease. Although this term has been used in the medical community since 1932, a significant increase in the number of publications occurs at the end of the 20th century and the beginning of the 21st [...] Read more.
One of the inflammatory bowel diseases is Crohn’s disease. Although this term has been used in the medical community since 1932, a significant increase in the number of publications occurs at the end of the 20th century and the beginning of the 21st century. Crohn’s disease is a disease that cannot be fully cured. In many cases, it is chronic, i.e., recurrent. All preventive and therapeutic measures taken by doctors are aimed at inhibiting the development of the disease and minimizing the occurrence of any potential “side effects” resulting from the developing disease. One of the diagnostic methods is the qualitative and quantitative determination of metalloproteinases in inflammatory tissues and in the blood. The aim of the study was the quantitative and qualitative determination of metalloproteinases in inflammatory bowel tissues in patients diagnosed with Crohn’s disease. The in vitro study was performed on surgical tissues from patients diagnosed with Crohn’s disease. The results show that in inflammatory tissues the concentration of metalloproteinases -3, -7, -8, -9 was higher compared to tissues taken from the resection margin without signs of inflammation, defined as healthy. The experiment confirmed that the biochemical test, which is the determination of metalloproteinases in tissues, is a useful diagnostic tool to differentiate inflammatory from non-inflammatory tissues. Full article
(This article belongs to the Special Issue New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer)
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Review

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21 pages, 375 KiB  
Review
Crohn’s Disease: Basic Characteristics of the Disease, Diagnostic Methods, the Role of Biomarkers, and Analysis of Metalloproteinases: A Review
by Grzegorz Pasternak, Grzegorz Chrzanowski, David Aebisher, Angelika Myśliwiec, Klaudia Dynarowicz, Dorota Bartusik-Aebisher, Barbara Sosna, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka and Rafał Filip
Life 2023, 13(10), 2062; https://doi.org/10.3390/life13102062 - 15 Oct 2023
Cited by 2 | Viewed by 1677
Abstract
Crohn’s disease is a chronic inflammatory bowel disease that affects the ileum and/or large intestine. At the same time, it can also affect any other part of the human body, i.e., from the mouth to the anus. In Crohn’s disease, the physiology and [...] Read more.
Crohn’s disease is a chronic inflammatory bowel disease that affects the ileum and/or large intestine. At the same time, it can also affect any other part of the human body, i.e., from the mouth to the anus. In Crohn’s disease, the physiology and functioning of the epithelial barrier are inhibited due to the correlation of various factors, such as the environment, genetic susceptibility or intestinal microbiota. The symptoms are very troublesome and cause a significant reduction in quality of life, sometimes occurring with paralyzing permanent damage to the digestive tract, requiring enteral or parenteral nutrition throughout life. In order to make a proper and accurate diagnosis, an appropriately selected diagnostic path in a given clinical entity is necessary. Standard diagnostic methods are: laboratory examination, histopathological examination, endoscopic examination, X-ray, computed tomography, ultrasound examination and magnetic resonance imaging. Medical biology and the analysis of metalloproteinases have also proved helpful in diagnosing changes occurring as a result of Crohn’s disease. Here we provide a thorough review of the latest reports on Crohn’s disease and its genetic conditions, symptoms, morphology, diagnosis (including the analysis of Crohn’s disease biomarkers, i.e., metalloproteinases) and treatment. Full article
(This article belongs to the Special Issue New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer)
16 pages, 1943 KiB  
Review
The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease
by N. M. Liyanage, D. P. Nagahawatta, Thilina U. Jayawardena and You-Jin Jeon
Life 2023, 13(4), 1026; https://doi.org/10.3390/life13041026 - 16 Apr 2023
Cited by 8 | Viewed by 2775
Abstract
Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural [...] Read more.
Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural substances, such as seaweed polysaccharides, to treat IBD’s main pathologic treatment targets. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae, and fucoidan in brown algae. These are effective candidates for drug development and functional nutrition products. Algal polysaccharides treat IBD through therapeutic targets, including inflammatory cytokines, adhesion molecules, intestinal epithelial cells, and intestinal microflora. This study aimed to systematically review the potential therapeutic effects of algal polysaccharides on IBD while providing the theoretical basis for a nutritional preventive mechanism for IBD and the restoration of intestinal health. The results suggest that algal polysaccharides have significant potential in complementary IBD therapy and further research is needed for fully understanding their mechanisms of action and potential clinical applications. Full article
(This article belongs to the Special Issue New Insights into Chronic Inflammation: Inflammatory Bowel Disease and Gastrointestinal Cancer)
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