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Chlamydia trachomatis Pathogenicity and Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 2541

Special Issue Editor

Special Issue Information

Dear Colleagues,

Chlamydia trachomatis, responsible for genital infection, trachoma, and lymphogranuloma venereum according to the specific serotype, is still a relevant public health problem worldwide due to the high prevalence of asymptomatic infections in both women and men, favoring the onset of chronic complications, such as pelvic inflammatory disease and ectopic pregnancy for women, epididymitis and proctitis for men, as well as reactive arthritis and infertility for both sexes. These are likely due to the long-term persistence of C. trachomatis infection in the host organism, leading to a chronic inflammatory state and the consequent tissue damage.

To date, many critical questions on the pathogenesis of C. trachomatis infection remain to be answered. For example, the nature of the host innate immune response to C. trachomatis, as well as the virulence factors involved, is a key issue that needs further investigation to clarify the molecular and cellular mechanisms responsible for tissue damage associated to chlamydial infection.

In order to shed light on the etiopathogenesis and host cell response mechanisms of damaging C. trachomatis infection, this Special Issue is dedicated to current progress in chlamydial infection pathogenesis and related diseases.

Dr. Rosa Sessa
Guest Editor

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Keywords

  • Chlamydia trachomatis
  • virulence factors
  • host susceptibility or resistance
  • innate and adaptive
  • immune responses
  • genetic studies
  • cervico-vaginal microbiota
  • clinical outcomes with molecular study

Published Papers (2 papers)

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Research

11 pages, 621 KiB  
Article
HLA-DQB1*06 and Select Neighboring HLA Variants Predict Chlamydia Reinfection Risk
by Kanupriya Gupta, Howard W. Wiener, Hemant K. Tiwari and William M. Geisler
Int. J. Mol. Sci. 2023, 24(21), 15803; https://doi.org/10.3390/ijms242115803 - 31 Oct 2023
Viewed by 740
Abstract
Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially HLA DQB1*06. However, the potential role of DQB1*06 in influencing reinfection risk has still not been established. The purpose of this study was to determine whether the [...] Read more.
Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially HLA DQB1*06. However, the potential role of DQB1*06 in influencing reinfection risk has still not been established. The purpose of this study was to determine whether the association of DQB1*06 with chlamydia reinfection was impacted by any other nearby HLA class II variants that were also associated with reinfection. We used next-generation sequencing to map HLA class II variants spanning the HLA-DQ and -DR loci. DQB1*06 as well as DQB1*04 were confirmed as significant predictors of chlamydia reinfection, when controlling for age and percent African ancestry. SKAT analysis revealed one region each in DRB1, DRB5, DQA2, and three intergenic regions that had variants associated with reinfection. Further analyses of these variants revealed that rs112651494 within DRB5 and an intergenic SNP rs617058 in DRB1:DQA1 were significantly associated with reinfection, but this did not impact the significance of the association of DQB1*06 or DQB1*04 with reinfection. Full article
(This article belongs to the Special Issue Chlamydia trachomatis Pathogenicity and Disease 2.0)
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11 pages, 3154 KiB  
Article
In-Silico Functional Metabolic Pathways Associated to Chlamydia trachomatis Genital Infection
by Simone Filardo, Marisa Di Pietro, Marta De Angelis, Gabriella Brandolino, Maria Grazia Porpora and Rosa Sessa
Int. J. Mol. Sci. 2022, 23(24), 15847; https://doi.org/10.3390/ijms232415847 - 13 Dec 2022
Viewed by 1300
Abstract
The advent of high-throughput technologies, such as 16s rDNA sequencing, has significantly contributed to expanding our knowledge of the microbiota composition of the genital tract during infections such as Chlamydia trachomatis. The growing body of metagenomic data can be further exploited to [...] Read more.
The advent of high-throughput technologies, such as 16s rDNA sequencing, has significantly contributed to expanding our knowledge of the microbiota composition of the genital tract during infections such as Chlamydia trachomatis. The growing body of metagenomic data can be further exploited to provide a functional characterization of microbial communities via several powerful computational approaches. Therefore, in this study, we investigated the predicted metabolic pathways of the cervicovaginal microbiota associated with C. trachomatis genital infection in relation to the different Community State Types (CSTs), via PICRUSt2 analysis. Our results showed a more rich and diverse mix of predicted metabolic pathways in women with a CST-IV microbiota as compared to all the other CSTs, independently from infection status. C. trachomatis genital infection further modified the metabolic profiles in women with a CST-IV microbiota and was characterized by increased prevalence of the pathways for the biosynthesis of precursor metabolites and energy, biogenic amino-acids, nucleotides, and tetrahydrofolate. Overall, predicted metabolic pathways might represent the starting point for more precisely designed future metabolomic studies, aiming to investigate the actual metabolic pathways characterizing C. trachomatis genital infection in the cervicovaginal microenvironment. Full article
(This article belongs to the Special Issue Chlamydia trachomatis Pathogenicity and Disease 2.0)
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