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Antibacterial Activity against Drug-Resistant Strains, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 26 July 2024 | Viewed by 482

Special Issue Editors

Department of Public Health and Infectious Diseases, “Sapienza” University, 00185 Rome, Italy
Interests: identification of host defence factors towards C. trachomatis genital infection; study of C. trachomatis role in the pathogenesis of male infertility; study of chlamydia-host cell interaction; identification of new anti-chlamydial drugs; study of the etiopathogenic role Chlamydia pneumoniae in the chronic inflammatory diseases
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Guest Editor
Department of Public Health and Infectious Diseases, “Sapienza” University, 00185 Rome, Italy
Interests: human microbiota; bioinformatic analysis; host-pathogen interactions; identification of novel antimicrobial molecules; study of C. trachomatis pathogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antibacterial resistance is one of the greatest threats to human health, resulting in an increased number of deaths due to once curable infectious diseases. Indeed, the emergence of drug-resistant bacteria has been prioritized by the World Health Organization as one of the top ten public health problems worldwide. Over the years, the widespread misuse and overuse of antibiotics in the human, animal, and environmental domains have led to the global rapid spread of multi-drug resistant pathogens, beginning with the emergence of methicillin-resistant Staphylococcus aureus. The following appearance of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae all over the globe, including some Escherichia coli strains and the ESKAPE pathogens, has further limited the treatment options at our disposal. In addition, other emerging bacterial pathogens, like intracellular bacteria, are acquiring increasing resistance to standard treatments, hence the need for novel molecules. The aim of this Special Issue is to encourage original articles tackling this current issue, including the antibacterial activity of novel compounds as well as the molecular mechanisms underlying the antibiotic resistance for the discovery of new promising targets.

Dr. Rosa Sessa
Dr. Simone Filardo
Guest Editors

Manuscript Submission Information

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Keywords

  • antibacterial activity
  • novel antimicrobial agents
  • drug-resistant strains
  • molecular mechanisms
  • emerging drug-resistant pathogens
  • genetic determinants
  • impact of MDR pathogens on human health
  • molecular methods for the diagnosis of antibiotic resistance

Published Papers (1 paper)

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Research

17 pages, 7075 KiB  
Article
Anti-Biofilm Activity of Oleacein and Oleocanthal from Extra-Virgin Olive Oil toward Pseudomonas aeruginosa
by Marisa Di Pietro, Simone Filardo, Roberto Mattioli, Giuseppina Bozzuto, Giammarco Raponi, Luciana Mosca and Rosa Sessa
Int. J. Mol. Sci. 2024, 25(9), 5051; https://doi.org/10.3390/ijms25095051 - 6 May 2024
Viewed by 329
Abstract
New antimicrobial molecules effective against Pseudomonas aeruginosa, known as an antibiotic-resistant “high-priority pathogen”, are urgently required because of its ability to develop biofilms related to healthcare-acquired infections. In this study, for the first time, the anti-biofilm and anti-virulence activities of a polyphenolic [...] Read more.
New antimicrobial molecules effective against Pseudomonas aeruginosa, known as an antibiotic-resistant “high-priority pathogen”, are urgently required because of its ability to develop biofilms related to healthcare-acquired infections. In this study, for the first time, the anti-biofilm and anti-virulence activities of a polyphenolic extract of extra-virgin olive oil as well as purified oleocanthal and oleacein, toward P. aeruginosa clinical isolates were investigated. The main result of our study was the anti-virulence activity of the mixture of oleacein and oleocanthal toward multidrug-resistant and intermediately resistant strains of P. aeruginosa isolated from patients with ventilator-associated pneumonia or surgical site infection. Specifically, the mixture of oleacein (2.5 mM)/oleocanthal (2.5 mM) significantly inhibited biofilm formation, alginate and pyocyanin production, and motility in both P. aeruginosa strains (p < 0.05); scanning electron microscopy analysis further evidenced its ability to inhibit bacterial cell adhesion as well as the production of the extracellular matrix. In conclusion, our results suggest the potential application of the oleacein/oleocanthal mixture in the management of healthcare-associated P. aeruginosa infections, particularly in the era of increasing antimicrobial resistance. Full article
(This article belongs to the Special Issue Antibacterial Activity against Drug-Resistant Strains, 2nd Edition)
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