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Endocrine Disruptors Leading to Obesity and Related Disease

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 6745

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Special Issue Editor

Prof. Dr. Eui-Bae Jeung

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Guest Editor

Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea
Interests: reproductive toxicology; endocrine disruptors; animal alternative tests; guidelines of toxicology; calcium metabolism; steroid receptors; stem cells in pharmacological and toxicological test
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Special Issue Information

Dear Colleagues,

Endocrine disruptors— also referred to as hormonally active agents, endocrine-disrupting chemicals, or endocrine-disrupting compounds—are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause various issues such as cancerous tumors, birth defects, and reproductive diseases. It has been known that endocrine-disrupting chemicals also increase the risk of various chronic disorders, such as obesity and diabetes. Obesity is a complex disease involving an excessive amount of body fat. Obesity is not just a cosmetic concern, it is a medical problem that increases your risk of other diseases and health problems, such as heart disease, diabetes, high blood pressure and certain cancers.

Contributions to this Special Issue will provide new insights into the correlation between endocrine disruptors and obesity, as well as its related diseases, and will deepen our understanding of how they induce adverse effects.

We encourage the submission of both original research articles and topical reviews on all aspects of endocrine disruptors and obesity-related diseases. All submitted articles will undergo peer review.

Prof. Dr. Eui-Bae Jeung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

endocrine disruptors
hormones
estrogenic activity
obesity
diet
diabetes
metabolic disease

Published Papers (3 papers)

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Research

12 pages, 494 KiB

Open AccessArticle

Biomarkers of Glucose Metabolism Alterations and the Onset of Metabolic Syndrome in Survivors of Childhood Acute Lymphoblastic Leukemia

by Katarzyna Konończuk, Katarzyna Muszyńska-Rosłan, Karolina Konstantynowicz-Nowicka, Maryna Krawczuk-Rybak, Adrian Chabowski and Eryk Latoch

Int. J. Mol. Sci. 2022, 23(7), 3712; https://doi.org/10.3390/ijms23073712 - 28 Mar 2022

Cited by 7 | Viewed by 2072

Abstract

Owing to advances in treatment modalities and supportive care, overall survival rates have reached up to 90% among children with acute lymphoblastic leukemia (ALL). However, due to the underlying illness and therapy, they are at a greater risk of developing lifestyle diseases. Hence, special attention is paid to early detection of the components of metabolic syndrome (MetS). This study aimed at investigating the association of plasma levels of nine diabetes markers with being overweight and components of MetS in ALL survivors. The study included 56 subjects with mean age of 12.36 ± 5.15 years. The commercially available Bio-Plex Pro Human Diabetes 10-Plex Panel kit was used to evaluate levels of diabetes biomarkers. ALL survivors presented statistically higher concentrations of GIP (p = 0.026), glucagon (p = 0.001), leptin (p = 0.022), and PAI-1 (p = 0.047), whereas the concentration of ghrelin was lower (p < 0.001) compared to the control group. Moreover, subjects within normal BMI range showed higher GIP (p = 0.005) and lower ghrelin concentration (p < 0.001) compared to healthy peers. At least one risk factor of MetS was present in 58.9% of participants, who showed significantly higher levels of C-peptide (p = 0.028), leptin (p = 0.003), and PAI-1 (p = 0.034) than survivors who did not meet any MetS criteria. In conclusion, ALL survivors are at greater risk of disturbances in carbohydrate metabolism. Understanding the pathogenesis and applicability of diabetes markers is crucial for developing strategies to prevent metabolic syndrome in ALL survivors. Full article

(This article belongs to the Special Issue Endocrine Disruptors Leading to Obesity and Related Disease)

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21 pages, 5543 KiB

Open AccessArticle

Prenatal Octamethylcyclotetrasiloxane Exposure Impaired Proliferation of Neuronal Progenitor, Leading to Motor, Cognition, Social and Behavioral Functions

by Dinh Nam Tran, Seon-Mi Park, Eui-Man Jung and Eui-Bae Jeung

Int. J. Mol. Sci. 2021, 22(23), 12949; https://doi.org/10.3390/ijms222312949 - 30 Nov 2021

Cited by 4 | Viewed by 1793

Abstract

Cyclic siloxane octamethylcyclotetrasiloxane (D4) has raised concerns as an endocrine-disrupting chemical (EDC). D4 is widely used in detergent products, cosmetics, and personal care products. Recently, robust toxicological data for D4 has been reported, but the adverse effects of D4 on brain development are unknown. Here, pregnant mice on gestational day 9.5 were treated daily with D4 to postnatal day 28, and the offspring mice were studied. The prenatal D4-treated mice exhibited cognitive dysfunction, limited memory, and motor learning defect. Moreover, prenatal D4 exposure reduced the proliferation of neuronal progenitors in the offspring mouse brain. Next, the mechanisms through which D4 regulated the cell cycle were investigated. Aberrant gene expression, such as cyclin-dependent kinases CDK6 and cyclin-dependent kinase inhibitor p27, were found in the prenatal D4-treated mice. Furthermore, the estrogen receptors ERa and ERb were increased in the brain of prenatal D4-treated mice. Overall, these findings suggest that D4 exerts estrogen activity that affects the cell cycle progression of neuronal progenitor cells during neurodevelopment, which may be associated with cognitive deficits in offspring. Full article

(This article belongs to the Special Issue Endocrine Disruptors Leading to Obesity and Related Disease)

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Figure 1

17 pages, 3712 KiB

Open AccessArticle

Combined Exposure to Diazinon and Nicotine Exerts a Synergistic Adverse Effect In Vitro and Disrupts Brain Development and Behaviors In Vivo

by Bonn Lee, Seon Mi Park, SunHwa Jeong, KangMin Kim and Eui-Bae Jeung

Int. J. Mol. Sci. 2021, 22(14), 7742; https://doi.org/10.3390/ijms22147742 - 20 Jul 2021

Cited by 4 | Viewed by 2026

Abstract

A real-life environment during pregnancy involves multiple and simultaneous exposures to toxic chemicals. Perinatal exposures to toxic chemicals have been reported to exert an inhibitory effect on mouse neural development and behaviors. However, the effect of combined exposures of organophosphate and nicotine has not been previously reported. In this study, we investigated whether a combined exposure of diazinon and nicotine can have a synergistic effect. The effects of the combined chemical exposure on cell viability and neuronal differentiation were examined using mouse Sox1-GFP cells. Additionally, mice were maternally administered 0.18 mg/kg diazinon, a no adverse effect level (NOAEL) dose, combined with 0.4, 1, and 2 mg/kg nicotine. Mice offspring underwent behavior tests to assess locomotor, depressive, cognitive, and social behaviors. Morphological change in the brain was investigated with immunolocalization. We revealed that the combined exposure to diazinon and nicotine can have a synergistic adverse effect in vitro. In addition, the chemical-treated mouse offspring showed abnormalities in motor learning, compulsive-like behaviors, spatial learning, and social interaction patterns. Moreover, 0.18 mg/kg diazinon and 2 mg/kg nicotine co-exposure resulted in an increase in tyrosine hydroxylase (TH)-positive dopaminergic neurons. Thus, the findings suggest that perinatal co-exposure to nicotine and diazinon can result in abnormal neurodevelopment and behavior, even at low-level administration. Full article

(This article belongs to the Special Issue Endocrine Disruptors Leading to Obesity and Related Disease)

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