Gut Microbiota Derived Metabolites in Cardiovascular Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 14047
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, the association between gut microbiota derived metabolites and cardiovascular disease has gained wide interest and targeting gut microbiome and metabolic pathway may become a potential therapeutic strategy to prevent and treat cardiovascular disease. Cardiovascular disease is the leading cause of death worldwide and takes one-third of all deaths globally each year. Atherosclerosis, a chronic inflammatory disease happened in artery wall, is the underlying mechanism of cardiovascular disease. The roles of gut microbiota derived metabolites in cardiovascular health and disease can be summarized as follows: modulation of cholesterol metabolism, lipid storage and energy metabolism, regulation of pro- or anti- inflammatory cytokine or chemokine biosynthesis and modulation of immunity. Hundreds of gut microbiota derived metabolites have been revealed to participate in cardiovascular disease pathogenesis. However, the molecular mechanisms need further investigation. Therefore, this Special Issue will be dedicated to publishing current advances on new gut microbiota derived metabolite discovery and its metabolic pathway, the microbes which encode this specific metabolic pathway, and molecular mechanisms linking to atherosclerosis and cardiovascular disease pathogenesis.
Dr. Zeneng Wang
Guest Editor
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Keywords
- gut microbiota-derived metabolites such as: short-chain fatty acids, trimethylamine n-oxide, amide lipid, aromatic amino acid derivatives, polyamines, hydrogen sulfide, lipopolysaccharide, polyphenols, secondary bile acids
- receptor recognition and signal transduction induced by metabolites
- metabolites initiating atherosclerosis
- microbial enzymes catalyzing biosynthesis of the metabolites
- inhibitors, prebiotic and probiotic modulation of the metabolite production
- transcriptomic, proteomic, metabolic profile changes induced by metabolites
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