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Molecular and Cellular Basis of Allergies and Allergic Asthma

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 10911

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Special Issue Editor

Dr. Cenk Suphioglu

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Guest Editor

NeuroAllergy Research Laboratory (NARL), School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Waurn Ponds, VIC 3216, Australia
Interests: aerobiology; allergic asthma; allergy diagnostics; allergy immunotherapy reagents; cytokine signalling; epigenetics; food allergy; inhibitors of allergic reaction; inhibitors of Alzheimer’s disease; neuroscience; nutrition; pollen allergy; thunderstorm asthma
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Special Issue Information

Dear Colleagues,

We are organizing a Special Issue of IJMS on the “Molecular and Cellular Basis of Allergies and Allergic Asthma".

Allergies and allergic asthma are chronic health conditions that range in frequency and severity from mild to life-threatening symptoms, which vary from person to person. In particular, the importance of allergic asthma gained a great deal of international press and attention following Melbourne’s deadly thunderstorm asthma epidemic of 21 November 2016, which resulted in 10 deaths and thousands of sufferers seeking emergency medical attention. Although one can suffer from allergies without ever having a previous episode of an asthma attack, it is now known and well accepted that people with certain allergies (grass pollen and fungal spore allergies for example) can be particularly vulnerable to thunderstorm asthma epidemics, thus the importance of research on the molecular and cellular basis of allergies and allergic asthma.

This Special Issue is intended to present the latest findings related to the molecular and cellular basis of allergies and allergic asthma, as well as the molecular and cellular links between the two conditions. Although pure clinical studies will not be suitable for our journal, clinical submissions with biomolecular experiments are welcomed. Original research and review articles on all topics related to the molecular and cellular basis of allergies and allergic asthma are invited. I have the pleasure of inviting research scientists and clinicians from all relevant fields to submit their papers to this important and timely Special Issue. Please accept my sincere thanks for choosing to publish in IJMS. I look forward to your submissions for this highly interesting, relevant, and important Special Issue.

Dr. Cenk Suphioglu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

aerobiology
allergic asthma
allergy diagnostics
allergy immunotherapy reagents
cytokine signalling
epidemic thunderstorm asthma (ETSA)
inhibitors of allergic reaction
micronic particles
pollen allergy
pollen rupture
sub-pollen particles (SPPs)
thunderstorm asthma (TA)

Published Papers (4 papers)

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Research

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18 pages, 16204 KiB

Open AccessArticle

A CpG-Oligodeoxynucleotide Suppresses Th2/Th17 Inflammation by Inhibiting IL-33/ST2 Signaling in Mice from a Model of Adoptive Dendritic Cell Transfer of Smoke-Induced Asthma

by Xuena Yang, Beiting Su, Jing Liu, Li Zheng, Peizhi Tao, Yusen Lin, Xiaoling Zou, Hailing Yang, Wenbin Wu, Ping Meng, Tiantuo Zhang and Hongtao Li

Int. J. Mol. Sci. 2023, 24(4), 3130; https://doi.org/10.3390/ijms24043130 - 04 Feb 2023

Cited by 2 | Viewed by 1547

Abstract

Tobacco smoke exposure is a major environmental risk factor that facilitates the development and progression of asthma. Our previous study showed that CpG oligodeoxynucleotide (CpG-ODN) inhibits thymic stromal lymphopoietin (TSLP)-dendritic cells (DCs) to reduce Th2/Th17-related inflammatory response in smoke-related asthma. However, the mechanism underlying CpG-ODN -downregulated TSLP remains unclear. A combined house dust mite (HDM)/cigarette smoke extract (CSE) model was used to assess the effects of CpG-ODN on airway inflammation, Th2/Th17 immune response, and amount of IL-33/ST2 and TSLP in mice with smoke-related asthma induced by adoptive transfer of bone-marrow-derived dendritic cells (BMDCs) and in the cultured human bronchial epithelium (HBE) cells administered anti-ST2, HDM, and/or CSE. In vivo, compared to the HDM alone model, the combined HDM/CSE model had aggravated inflammatory responses, while CpG-ODN attenuated airway inflammation, airway collagen deposition, and goblet cell hyperplasia and reduced the levels of IL-33/ST2, TSLP, and Th2/Th17-cytokines in the combined model. In vitro, IL-33/ST2 pathway activation promoted TSLP production in HBE cells, which could be inhibited by CpG-ODN. CpG-ODN administration alleviated Th2/Th17 inflammatory response, decreased the infiltration of inflammatory cells into the airway, and improved the remodeling of smoke-related asthma. The underlying mechanism may be that CpG-ODN inhibits the TSLP-DCs pathway by downregulating the IL-33/ST2 axis. Full article

(This article belongs to the Special Issue Molecular and Cellular Basis of Allergies and Allergic Asthma)

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Review

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41 pages, 2662 KiB

Open AccessReview

The Role of Vitamins in the Pathogenesis of Asthma

by Dominika Zajac and Piotr Wojciechowski

Int. J. Mol. Sci. 2023, 24(10), 8574; https://doi.org/10.3390/ijms24108574 - 10 May 2023

Viewed by 4294

Abstract

Vitamins play a crucial role in the proper functioning of organisms. Disturbances of their levels, seen as deficiency or excess, enhance the development of various diseases, including those of the cardiovascular, immune, or respiratory systems. The present paper aims to summarize the role of vitamins in one of the most common diseases of the respiratory system, asthma. This narrative review describes the influence of vitamins on asthma and its main symptoms such as bronchial hyperreactivity, airway inflammation, oxidative stress, and airway remodeling, as well as the correlation between vitamin intake and levels and the risk of asthma in both pre- and postnatal life. Full article

(This article belongs to the Special Issue Molecular and Cellular Basis of Allergies and Allergic Asthma)

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13 pages, 1150 KiB

Open AccessReview

Drug-Induced Enterocolitis Syndrome in Children

by Paola Di Filippo, Annamaria Venanzi, Francesca Ciarelli, Beatrice Panetti, Sabrina Di Pillo, Francesco Chiarelli and Marina Attanasi

Int. J. Mol. Sci. 2023, 24(9), 7880; https://doi.org/10.3390/ijms24097880 - 26 Apr 2023

Cited by 1 | Viewed by 1735

Abstract

Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved. Symptoms include nausea, vomiting, abdominal pain, diarrhea, pallor, lethargy, and dehydration, which can be severe and result in hypovolemic shock. The main laboratory finding is neutrophilic leukocytosis. To the best of our knowledge, 12 cases of DIES (9 children-onset and 3 adult-onset cases) were described in the literature. DIES is a rare clinically well-described allergic disease; however, the pathogenetic mechanism is still unclear. It requires to be recognized early and correctly treated by physicians. Full article

(This article belongs to the Special Issue Molecular and Cellular Basis of Allergies and Allergic Asthma)

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13 pages, 2706 KiB

Open AccessReview

Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief

by Oliver William Massey and Cenk Suphioglu

Int. J. Mol. Sci. 2022, 23(19), 11166; https://doi.org/10.3390/ijms231911166 - 22 Sep 2022

Cited by 2 | Viewed by 2810

Abstract

Interleukin 5 (IL-5) is a major cytokine responsible for eosinophil proliferation, migration and degranulation. Eosinophils play a considerable role in the manifestation of type 2 asthma, and therefore this makes IL-5 a unique and clinically important target for therapeutic intervention. Due to the critical role that IL-5 plays in all areas of eosinophil activity, it has been identified and targeted by three therapeutics, Mepolizumab, Benralizumab and Reslizumab. This review describes the IL-5 pathway and presents the clinical trial history of the three IL-5 inhibitors, to provide insight into the role of IL-5 in clinical asthma presentation. Additionally, this review aims to foster further investigation into the IL-5 pathway by describing current novel therapeutic discovery strategies with monoclonal antibodies. Full article

(This article belongs to the Special Issue Molecular and Cellular Basis of Allergies and Allergic Asthma)

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