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Cells
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The Molecular and Cellular Basis for Allergies & Asthma 2020
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The Molecular and Cellular Basis for Allergies & Asthma 2020

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 15724

Special Issue Editor

Dr. Cenk Suphioglu

E-Mail Website1 Website2
Guest Editor
NeuroAllergy Research Laboratory (NARL), School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Waurn Ponds, VIC 3216, Australia
Interests: aerobiology; allergic asthma; allergy diagnostics; allergy immunotherapy reagents; cytokine signalling; epigenetics; food allergy; inhibitors of allergic reaction; inhibitors of Alzheimer’s disease; neuroscience; nutrition; pollen allergy; thunderstorm asthma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are organizing a Special Issue of Cells on the “Molecular and Cellular Basis for Allergies and Asthma".

This Special Issue is the second version of the topic, the first of which was highly successful with the publication of 11 seminal original research and review articles from international experts in the field. Cells has a rapid publication process, taking no more than a month from the initial submission to final publication. Thus, I highly recommend you take advantage of this 2nd version of this Special Issue on the “Molecular and Cellular Basis for Allergies and Asthma".

Allergies and asthma are chronic health conditions that range in frequency and severity from mild to life-threatening symptoms, which vary from person to person. In particular, the importance of allergic asthma gained a great deal of international press and attention following Melbourne’s recent deadly thunderstorm asthma epidemic of 21 November 2016, which resulted in 10 deaths and thousands of sufferers seeking emergency medical attention. Although one can suffer from allergies without ever having a previous episode of an asthma attack, it is now known and well accepted that people with certain allergies (grass pollen and fungal spore allergies for example) can be particularly vulnerable to thunderstorm asthma epidemics, thus the importance of research on the molecular and cellular basis for allergies and asthma.

The second version of this Special Issue is intended to present the latest findings related to the molecular and cellular basis for allergies and asthma, as well as the molecular and cellular links between the two conditions. Original research and review articles on all topics related to the molecular and cellular basis for allergies and asthma are invited. I have the pleasure of inviting research scientists and clinicians from all relevant fields to submit their papers to this important and timely Special Issue. Please accept my sincere thanks for choosing to publish in Cells. I look forward to your submissions for this highly interesting, relevant, and important Special Issue.

Dr. Cenk Suphioglu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Allergens
  • Allergic Asthma
  • Allergic rhinitis
  • Allergy
  • Asthma
  • Atopy
  • B cells
  • Basophils
  • Cellular Allergy
  • Cellular Asthma
  • Dendritic cells
  • Eosinophils
  • Helper T cells
  • Hypersensitivity
  • IgE
  • IL-4
  • IL-5
  • IL-13
  • Mast cells
  • Molecular Allergy
  • Molecular Asthma
  • Regulatory T cells
  • STAT6
  • Th1 cells
  • Th2 cells
  • Thunderstorm Asthma

Published Papers (3 papers)

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Research

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17 pages, 2919 KiB  
Article
Blood Eosinophils Subtypes and Their Survivability in Asthma Patients
by Andrius Januskevicius, Egle Jurkeviciute, Ieva Janulaityte, Virginija Kalinauskaite-Zukauske, Skaidrius Miliauskas and Kestutis Malakauskas
Cells 2020, 9(5), 1248; https://doi.org/10.3390/cells9051248 - 18 May 2020
Cited by 22 | Viewed by 4283
Abstract
Eosinophils subtypes as lung-resident (rEOS) and inflammatory (iEOS) eosinophils are different in surface protein expression, functions, response to IL-5 and localization in lungs. rEOS- and iEOS-like eosinophils are found in blood; thus, we aimed to investigate their quantity and survivability in asthma patients. [...] Read more.
Eosinophils subtypes as lung-resident (rEOS) and inflammatory (iEOS) eosinophils are different in surface protein expression, functions, response to IL-5 and localization in lungs. rEOS- and iEOS-like eosinophils are found in blood; thus, we aimed to investigate their quantity and survivability in asthma patients. A total of 40 individuals were included: 10 steroid-free non-severe allergic asthma (AA), and 18 severe non-allergic eosinophilic asthma (SNEA) patients, the control group consisted of 12 healthy non-smoking subjects (HS). A bronchial challenge with Dermatophagoides pteronysinnus allergen was performed for AA patients and HS. Blood eosinophils subtyping was completed with magnetic beads’ conjugated antibodies against surface CD62L. Eosinophils adhesion to hTERT airway smooth muscle (ASM) cells was measured by evaluating their peroxidase activity and viability by annexin V and propidium iodide staining. We found that the predominant blood eosinophil subtype in AA patients was iEOS, while rEOS prevailed in SNEA patients (p < 0.05). Moreover, rEOS demonstrated higher adhesion intensity compared with iEOS in all investigated groups. Both eosinophils subtypes of SNEA patients had higher survivability over the AA group. However, iEOS survivability from AA and SNEA groups was higher compared with rEOS under standard conditions, when rEOS survivability increased after their incubation with ASM cells. Bronchial allergen challenge abolished the dominance of blood iEOS in AA patients and prolonged only iEOS survivability. Though the challenge did not affect the adhesion of any eosinophils subtypes, the direct dependence of rEOS and iEOS survivability on their interaction with ASM cells was revealed (p < 0.05). These findings provide the premise for eosinophils subtype-oriented asthma treatment. Full article
(This article belongs to the Special Issue The Molecular and Cellular Basis for Allergies & Asthma 2020)
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Review

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16 pages, 2069 KiB  
Review
Initiation and Pathogenesis of Severe Asthma with Fungal Sensitization
by Meenakshi Tiwary and Amali E. Samarasinghe
Cells 2021, 10(4), 913; https://doi.org/10.3390/cells10040913 - 15 Apr 2021
Cited by 14 | Viewed by 5181
Abstract
Fungi represent one of the most diverse and abundant eukaryotes on earth, and their ubiquity and small proteolytically active products make them pervasive allergens that affect humans and other mammals. The immunologic parameters surrounding fungal allergies are still not fully elucidated despite their [...] Read more.
Fungi represent one of the most diverse and abundant eukaryotes on earth, and their ubiquity and small proteolytically active products make them pervasive allergens that affect humans and other mammals. The immunologic parameters surrounding fungal allergies are still not fully elucidated despite their importance given that a large proportion of severe asthmatics are sensitized to fungal allergens. Herein, we explore fungal allergic asthma with emphasis on mouse models that recapitulate the characteristics of human disease, and the main leukocyte players in the pathogenesis of fungal allergies. The endogenous mycobiome may also contribute to fungal asthma, a phenomenon that we discuss only superficially, as much remains to be discovered. Full article
(This article belongs to the Special Issue The Molecular and Cellular Basis for Allergies & Asthma 2020)
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18 pages, 7006 KiB  
Review
What Have In Vitro Co-Culture Models Taught Us about the Contribution of Epithelial-Mesenchymal Interactions to Airway Inflammation and Remodeling in Asthma?
by Emmanuel Twumasi Osei, Steven Booth and Tillie-Louise Hackett
Cells 2020, 9(7), 1694; https://doi.org/10.3390/cells9071694 - 15 Jul 2020
Cited by 22 | Viewed by 5738
Abstract
As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been associated with [...] Read more.
As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been associated with airway inflammation and remodeling, which has led to the hypothesis that aberrant activation of the asthmatic EMTU may lead to disease pathogenesis. Monoculture studies have aided in the understanding of the altered phenotype of airway epithelial and mesenchymal cells and their contribution to the pathogenesis of asthma. However, 3-dimensional (3D) co-culture models are needed to enable the study of epithelial-mesenchymal crosstalk in the setting of the in vivo environment. In this review, we summarize studies using 3D co-culture models to assess how defective epithelial-mesenchymal communication contributes to chronic airway inflammation and remodeling within the asthmatic EMTU. Full article
(This article belongs to the Special Issue The Molecular and Cellular Basis for Allergies & Asthma 2020)
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