ijms-logo

Journal Browser

Journal Browser

Unveiling the Dynamic World of Adaptive Unfolded Protein Responses in Metabolic Disease: A Scientist’s Perspective

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 373

Special Issue Editor


E-Mail Website
Guest Editor
College of Medicine, National Taiwan University, Taipei, Taiwan
Interests: nephrology; food safety; toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We call on you to embark on a captivating journey into the intricate realm of adaptive unfolded protein responses, as seen through the discerning eyes of a seasoned physician. In this exploration, we delve into the fascinating interplay between metabolic disease and the body’s ingenious mechanisms for coping with protein folding challenges. Join us as we unravel the mysteries of cellular resilience and witness the unfolding narrative of how the body adapts to the demands of metabolic intricacies. This compelling perspective, offered by a dedicated physician, unveils the nuanced strategies that underscore our understanding of metabolic diseases. Discover the synergy between medical insight and the unfolding events in our cells and gain a fresh appreciation for the intricate mechanisms of proteins in the context of metabolic well-being. Engage with the narrative that bridges physicians’ expertise with the complex mechanisms at play, promising a richer comprehension of the intersection between health and adaptive responses. For this Special Issue, we invite you to peer through the lens of a physician’s perspective, where science meets the art of healing, and the story of adaptive unfolded protein responses takes center stage in the captivating metabolic disease.

Prof. Dr. Chih-Kang Chiang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adaptive unfolded protein responses
  • metabolic disease
  • protein folding challenges
  • cellular resilience
  • metabolic intricacies

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

16 pages, 884 KiB  
Review
The Impact of Thallium Exposure in Public Health and Molecular Toxicology: A Comprehensive Review
by Yung Chang and Chih-Kang Chiang
Int. J. Mol. Sci. 2024, 25(9), 4750; https://doi.org/10.3390/ijms25094750 - 26 Apr 2024
Viewed by 236
Abstract
This review offers a synthesis of the current understanding of the impact of low-dose thallium (Tl) on public health, specifically emphasizing its diverse effects on various populations and organs. The article integrates insights into the cytotoxic effects, genotoxic potential, and molecular mechanisms of [...] Read more.
This review offers a synthesis of the current understanding of the impact of low-dose thallium (Tl) on public health, specifically emphasizing its diverse effects on various populations and organs. The article integrates insights into the cytotoxic effects, genotoxic potential, and molecular mechanisms of thallium in mammalian cells. Thallium, a non-essential heavy metal present in up to 89 different minerals, has garnered attention due to its adverse effects on human health. As technology and metallurgical industries advance, various forms of thallium, including dust, vapor, and wastewater, can contaminate the environment, extending to the surrounding air, water sources, and soil. Moreover, the metal has been identified in beverages, tobacco, and vegetables, highlighting its pervasive presence in a wide array of food sources. Epidemiological findings underscore associations between thallium exposure and critical health aspects such as kidney function, pregnancy outcomes, smoking-related implications, and potential links to autism spectrum disorder. Thallium primarily exerts cellular toxicity on various tissues through mitochondria-mediated oxidative stress and endoplasmic reticulum stress. This synthesis aims to shed light on the intricate web of thallium exposure and its potential implications for public health, emphasizing the need for vigilant consideration of its risks. Full article
Show Figures

Graphical abstract

Back to TopTop