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Molecular Research in Human Microbiome 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2567

Special Issue Editor


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Guest Editor
Department of Public Health and Infectious Diseases, Policlinico Umberto1 viale del Policlinico 155, Rome, Italy
Interests: bacterial antibiotic resistance; multidrug resistant microorganisms (MDR bacteria); probiotics; molecular laboratory methods; bacterial infections; biofilm and sonication; double carbapenem synergistic activity; association of antibiotics; enterobacterales; antimicrobial agents and resistance; relationship with the therapeutic approach; microbiota; Clostridium difficile infection; bacterial translocation and virulence factors; COVID 19 vaccines
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Special Issue Information

Dear Colleagues,

There are a variety of microorganisms in the human body, including fungi, bacteria and viruses, which account for about 1% to 3% of our body weight. They are usually harmless to the human body, and some can even protect our health by making vitamins, decomposing food and regulating immunity. These microorganisms form a large group called microbiome. More and more studies have shown that the changes of human microbiome are related to the occurrence of many diseases. For example alteration of the normal gut integrity is present during Clostridium difficile infections (CDI). In fact markers of microbial translocation, inflammation, and intestinal damage which are still present at clinical resolution of CDI, can be evaluated in patients with such disease. Improving microbiome may be applied to the treatment of diseases. Our microbiota plays a vital role in our health: it protects us against pathogens, promotes the development of our immune system, and helps metabolize various compounds. Maintaining a balanced microbial ecosystem is essential for defending our health. Several studies have shown significant changes in the balance of microorganisms in the host population or in the environment and this can be associated with significant changes in the balance of microorganisms in the host population. The goal of this special issue is to describe the human microbiome and analyse its role in human health and disease. In conclusion, this research topic is open in the broad subject area of microbiome and human health diseases. Welcome to submit a review of articles that study the human microbiome and analyse its role in human health and disease. The following are some recognized research cases, but not limited to the following: 

  • single group or multi group analysis of gene expression in microbiome and cell line (or animal model)
  • microbiota analysis of patients with inflammatory bowel disease
  • analyse metabolites secreted by the microbiome and their effects on patients with neuropathic diseases
  • analyse specific pathogenic organisms, their carcinogenic potential and potential mechanisms
  • changes in microbial populations in some diseases
  • Clostridium difficile infection

Dr. Maria Teresa Mascellino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • microbiome
  • microbial population
  • inflammatory bowel disease
  • bacterial translocation
  • Clostridium difficile infection

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Published Papers (1 paper)

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Research

27 pages, 3818 KiB  
Article
Mechanistic Insights into the Anti-Proliferative Action of Gut Microbial Metabolites against Breast Adenocarcinoma Cells
by Kayla Jaye, Muhammad A. Alsherbiny, Dennis Chang, Chun-Guang Li and Deep Jyoti Bhuyan
Int. J. Mol. Sci. 2023, 24(20), 15053; https://doi.org/10.3390/ijms242015053 - 10 Oct 2023
Cited by 3 | Viewed by 2013
Abstract
The gut microbiota undergoes metabolic processes to produce by-products (gut metabolites), which play a vital role in the overall maintenance of health and prevention of disease within the body. However, the use of gut metabolites as anticancer agents and their molecular mechanisms of [...] Read more.
The gut microbiota undergoes metabolic processes to produce by-products (gut metabolites), which play a vital role in the overall maintenance of health and prevention of disease within the body. However, the use of gut metabolites as anticancer agents and their molecular mechanisms of action are largely unknown. Therefore, this study evaluated the anti-proliferative effects of three key gut microbial metabolites—sodium butyrate, inosine, and nisin, against MCF7 and MDA-MB-231 breast adenocarcinoma cell lines. To determine the potential mechanistic action of these gut metabolites, flow cytometric assessments of apoptotic potential, reactive oxygen species (ROS) production measurements and proteomics analyses were performed. Sodium butyrate exhibited promising cytotoxicity, with IC50 values of 5.23 mM and 5.06 mM against MCF7 and MDA-MB-231 cells, respectively. All three metabolites were found to induce apoptotic cell death and inhibit the production of ROS in both cell lines. Nisin and inosine indicated a potential activation of cell cycle processes. Sodium butyrate indicated the possible initiation of signal transduction processes and cellular responses to stimuli. Further investigations are necessary to ascertain the effective therapeutic dose of these metabolites, and future research on patient-derived tumour spheroids will provide insights into the potential use of these gut metabolites in cancer therapy. Full article
(This article belongs to the Special Issue Molecular Research in Human Microbiome 2.0)
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