Nephrotoxicity 2022
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 12848
Special Issue Editor
Interests: nephrotoxicity; hepatotoxicity; cancer chemotherapy drugs; acetaminophen; fungicides; solvents; oxidative stress; 4-hydroxynonenal; proximal tubule; protein carbonylation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nephrotoxicity can be mediated through many different xenobiotics, including drugs, disinfection byproducts, environmental chemicals, metals, agricultural products, and solvents. The kidney is critical in the filtration and elimination of many substances from the body, but the kidney is metabolically active in the biotransformation and conjugation of foreign substances. The kidney is a target for toxicity by many structurally diverse chemicals, through poorly understood mechanisms. Part of the susceptibility of the kidney can be attributed to cellular accumulation to levels higher than plasma concentrations due to active transporter influx on the basolateral side of proximal tubular epithelial cells. Additionally, very little is known regarding the impact of nephrotoxic substances on the cell-signaling pathways involved in cell death and repair. This Special Issue will focus on examining the mechanisms of nephrotoxicity as well as the potential of confounding factors to increase susceptibility to renal toxicity such as aging or the presence of diseases such as diabetes. This Special Issue will also examine potential biomarkers of nephrotoxicity. Additionally, articles in this Special Issue will address the impact of nephrotoxic substances on cell signaling and protein expression that influence cell function.
Prof. Dr. Monica Valentovic
Guest Editor
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Keywords
- nephrotoxicity
- metabolomics
- biomarkers
- pharmacogenomics
- proximal tubule
- pharmaceutical agents
- natural products
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