Neurotrophins: Roles and Function in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 34681
Special Issue Editor
Interests: neurotrophins; addiction; toxicology; polyphenols; oxidative stress; neurobiology; behavior
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurotrophins are a family of proteins inducing the development, survival, and function of nerve cells. Neurotrophins belong to a class of growth factors, secreted proteins that signal selected cells to survive, differentiate or grow. Growth factors such as neurotrophins that promote the survival of neurons are also known as neurotrophic factors. Neurotrophic factors are produced by a specific target tissue and actively prevent the associated neuron from initiating apoptosis (programmed cell death), allowing the neurons to survive. Neurotrophins also elicit the differentiation of progenitor cells, to form neurons. Although most brain neurons are formed prenatally, brain limbic areas maintain the power to produce new neurons from neural stem cells, a process known as neurogenesis. Neurotrophins include polypeptides such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4/5. Neurotrophins and their receptors are also involved in many seemingly unrelated events, including neuronal disorders, aging-related disorders, cancer physiology, ocular diseases, autoimmune diseases, addiction, pregnancy, delivery and postpartum, oxidative-stress-related diseases, and cardiometabolic diseases such as type 2 diabetes mellitus, obesity, and metabolic syndrome.
This Special Issue focuses on the current understanding and future research directions regarding the neurotrophins and their receptors. We warmly welcome original research and review articles relating to this hot topic.
Prof. Dr. Marco Fiore
Guest Editor
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Keywords
- neuroinflammation
- brain
- toxicology
- cell growth
- neurogenesis
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