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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Diseases: From Pathology to Therapeutics
edited by
submission deadline 31 Oct 2024 | Viewed by 209 | Submission Open
Keywords: cardiovascular diseases; pathologies; cardiac progenitor cells; molecular pathways; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Membrane Proteins and Ion Channels
edited by
submission deadline 31 Oct 2024 | Viewed by 208 | Submission Open
Keywords: membrane proteins; ion channels; cell membranes
(This special issue belongs to the Section Molecular Biophysics)
Environmental Heavy Metals with Their Benefits and Risks for Human Health
edited by
submission deadline 31 Oct 2024 | Viewed by 207 | Submission Open
Keywords: heavy metals; metal compound; iron; copper; cadmium; arsenic; oxidative stress; cell death; toxicology; Wilson disease; hemochromatosis
(This special issue belongs to the Section Molecular Toxicology)
Development and Efficacy of Leptin
edited by Patricia Grasso
submission deadline 31 Oct 2024 | Viewed by 203 | Submission Open
Keywords: adrenal function; anorexia; bone turn over; diabetes; drug development; cancer; cognitive function; immune response; leptin; obesity; reproduction; serum lipids synthetic peptides
(This special issue belongs to the Section Molecular Biology)
Fundamental and Applicative Scientific Motivations to Pass the Border between Natural Multifunctional Molecules and Their Biomimetic Artificial Derivatives submission deadline 31 Oct 2024 | Viewed by 201 | Submission Open
Keywords: multifunctional compounds (MFCs); heterocyclic building blocks; macrocycles nanomaterials; clinical applications; nanomedicine; nanoenergy; cell cycle determination; medicinal chemistry; technical applications; computational chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Impact of High-Value Compounds from Agri-Food and Waste Sources on Cellular Metabolism submission deadline 31 Oct 2024 | Viewed by 200 | Submission Open
Keywords: phytochemicals; agri-food waste; nutraceutical; cell metabolism; mitochondria; antioxidants; ROS; anti-cancer
(This special issue belongs to the Section Biochemistry)
MAPK Signaling Cascades in Human Health and Diseases 2.0
edited by Galia Maik-Rachline
submission deadline 31 Oct 2024 | Viewed by 198 | Submission Open
Keywords: ERK1/2; p38; JNK; ERK5; MEK; MEKK; raf; stimulated nuclear translocation; targeted therapy; resistance mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mycotoxins and Food Toxicology
edited by
submission deadline 31 Oct 2024 | Viewed by 197 | Submission Open
Keywords: mycotoxins; food toxicology; biodegradation; detoxification; microorganisms
(This special issue belongs to the Section Molecular Toxicology)
Molecular Genetics of Eye Diseases
edited by Hui-Ju Lin
submission deadline 31 Oct 2024 | Viewed by 197 | Submission Open
Keywords: genetic ophthalmology; genome engineering; gene phenotypes; genetic payloads; gene delivery methods; retinoblastoma; glaucoma; age-related maculopathy; keratoconjunctivitis sicca; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insights into Protein Structure and Folding
edited by
submission deadline 31 Oct 2024 | Viewed by 195 | Submission Open
Keywords: protein folding; protein function; protein structure
(This special issue belongs to the Section Molecular Biophysics)
Application of Electrochemical Materials in Molecular Biology submission deadline 31 Oct 2024 | Viewed by 195 | Submission Open
Keywords: electrochemistry; (bio)analytical chemistry; molecular biology; point-of-care; nanomaterials; (bio)molecules
(This special issue belongs to the Section Materials Science)
Nanotechnology in Drug Delivery: Applications and Perspectives
edited by Ádám Juhász
submission deadline 31 Oct 2024 | Viewed by 190 | Submission Open
Keywords: nanostructured materials; drug delivery; drug– carrier interactions; hydrogel; aerogels; associated colloids; surfactants; macromolecules; blood– brain barrier; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
Recent Molecular Trends and Prospects in Pancreatic Cancer
edited by Tae Seung Lee
submission deadline 31 Oct 2024 | Viewed by 184 | Submission Open
Keywords: pancreatic cancer; molecular approach; target therapy
(This special issue belongs to the Section Molecular Oncology)
New Strategies to Improve the Detection of Human Papillomavirus (HPV) Persisting Infections submission deadline 31 Oct 2024 | Viewed by 184 | Submission Open
Keywords: human papillomavirus; HPV; viral load; genotyping; oncogenic transcripts; biomarkers
(This special issue belongs to the Section Molecular Microbiology)
The Molecular Link between Nutrition and Obesity
edited by
submission deadline 31 Oct 2024 | Viewed by 183 | Submission Open
Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Beyond Transgenics: Leveraging Humanized Mice for Disease Modeling and Therapeutics
edited by and Michael W. Melkus
submission deadline 31 Oct 2024 | Viewed by 182 | Submission Open
Keywords: humanized mouse; cancer; infectious disease; cardiovascular disease; respiratory diseases; immune diseases; lymphatic diseases; nervous system diseases; metabolic diseases; endocrine diseases; skin diseases; musculoskeletal diseases; male and female reproductive diseases; urinary diseases; rare diseases; liver disease/hepatotoxicity; humanized models of human development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Skeletal Muscle Metabolism and Diseases
edited by Shen-Liang Chen
submission deadline 31 Oct 2024 | Viewed by 179 | Submission Open
Keywords: muscle; metabolism; mitochondria; peroxisome; stem cell; cahcexia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Analysis Based on CRISPR/Cas9 Technology : 2nd Edition
edited by and
submission deadline 31 Oct 2024 | Viewed by 178 | Submission Open
Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Hypertension and Cardiovascular Disease 2.0
edited by Edyta Zbroch
submission deadline 31 Oct 2024 | Viewed by 177 | Submission Open
Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathology and Novel Therapies for Lymphoma
edited by Fulvio Massaro
submission deadline 31 Oct 2024 | Viewed by 176 | Submission Open
Keywords: Hodgkin lymphoma; non-Hodgkin lymphoma; hematopathology; biomarker; new therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Translational Research in Angiogenesis—a Key Tool for Developing Therapeutic Strategies towards Tissue Regeneration
edited by Ektoras Hadjipanayi
submission deadline 31 Oct 2024 | Viewed by 172 | Submission Open
Keywords: angiogenesis; wound bed; stromal microenvironment; stem cells; tissue repair; hypoxia; growth factors; molecular signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroimaging and Molecular Research on Depressive Disorder
edited by Keita Watanabe
submission deadline 31 Oct 2024 | Viewed by 172 | Submission Open
Keywords: neuroimaging; molecular research; neurotransmitter; depressive disorder; antidepressants
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research Progress of Antibacterial Material
edited by
submission deadline 31 Oct 2024 | Viewed by 170 | Submission Open
Keywords: antibacterial; microcides; nanoparticles; nanostructures; molecular engineering; ROS induction
(This special issue belongs to the Section Materials Science)
Molecular Insights and Epigenetic Factors in Aging and Age-Related Diseases
edited by
submission deadline 31 Oct 2024 | Viewed by 166 | Submission Open
Keywords: aging; cellular senescence; epigenetics; genomic instability; age-related diseases; cardiovascular disorders; neurodegenerative diseases; cancer; metabolic syndromes; lifestyle interventions; nutrition; senolytic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Scale Research of Energy Materials
edited by Paolo Umari
submission deadline 31 Oct 2024 | Viewed by 163 | Submission Open
Keywords: photovoltaics; density functional theory; quantum chemistry; catalysis; surfaces; charge transport; catalytic activity
(This special issue belongs to the Section Materials Science)
Molecular, Translational and Clinical Research of Cancer Structural Biomarkers
edited by
submission deadline 31 Oct 2024 | Viewed by 155 | Submission Open
Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
New Advances in Plant-Fungal Interactions, 2nd Edition
edited by
submission deadline 31 Oct 2024 | Viewed by 151 | Submission Open
Keywords: coding RNAs; non-coding RNAs; axial regulation mechanisms; bidirectional regulation mechanisms; pathogenic mechanisms of pathogens; resistance responses of the host
(This special issue belongs to the Section Molecular Plant Sciences)
From Basic Science to Treatment Strategies: Personalized Cancer Therapy, 2nd Edition
edited by Atif Hussein
submission deadline 31 Oct 2024 | Viewed by 151 | Submission Open
Keywords: targeted therapy; personalized medicine; immunotherapy; circulating tumor DNA; prognosis; genomic profiling; liquid biopsies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research and Development of Novel Electroactive Materials for Reduction/Oxidation Processes
edited by
submission deadline 31 Oct 2024 | Viewed by 150 | Submission Open
Keywords: electrochemistry; electrocatalysis; synthesis of metallic electrode materials; fabrication of alloys; crystalline structure modification; tailoring of the electrode morphology
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Role of EGFR in Colorectal Cancer submission deadline 31 Oct 2024 | Viewed by 149 | Submission Open
Keywords: EGFR; RAS; biomarkers/prognosis; resistance mechanisms; tumor microenvironment; EGFR signaling pathways; EGFR inhibitors; onco-immunology
(This special issue belongs to the Section Biochemistry)
Insect-Plant Interactions: From Genes to Biochemical Elements
edited by
submission deadline 31 Oct 2024 | Viewed by 148 | Submission Open
Keywords: genomics; proteomics; metabolomics; infochemicals; phytochemicals
(This special issue belongs to the Section Molecular Plant Sciences)
Defeating Multidrug Resistance: Innovations in Cancer Therapy
edited by Dawid Przystupski
submission deadline 31 Oct 2024 | Viewed by 146 | Submission Open
Keywords: targeted cancer therapy; multidrug resistance; molecular mechanisms of cancer; pharmacogenomics; biomarkers in oncology; personalized medicine; cancer genomics; therapeutic strategies; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
The Impact and Alterations of Hormones in Age-Related Diseases and Comorbidities
edited by
submission deadline 31 Oct 2024 | Viewed by 145 | Submission Open
Keywords: aging; age-related complications; comorbidities; aging and hormones; immunosenescence; impact of hormones in physiology and pathophysiology; immunocompromised conditions; neurodegenerative disorders; bodily homeostasis; healthy aging
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Research of Nuclear Receptors in Disease
edited by Shigeaki Kato
submission deadline 31 Oct 2024 | Viewed by 141 | Submission Open
Keywords: nuclear receptors; steroid hormones; fat-soluble vitamins; cancer; non-communicable diseases; synthetic ligands
(This special issue belongs to the Section Biochemistry)
Circadian Rhythms in the Molecular Pathogenesis of Chronic Diseases: Implications for Prevention and Therapeutic Strategies
edited by Vijay K. Yechoor, Ke Ma and Antoni Paul
submission deadline 31 Oct 2024 | Viewed by 141 | Submission Open
Keywords: circadian rhythms; cell-intrinsic clocks; molecular underpinnings; cardiometabolic diseases; chronotherapy interventions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pediatric Autoimmune Diseases: Molecular Basis, Diagnostic and Therapy
edited by
submission deadline 31 Oct 2024 | Viewed by 141 | Submission Open
Keywords: autoimmunity; immune regulation; biomarker analysis; molecular pathways; precision medicine; genetics
(This special issue belongs to the Section Molecular Immunology)
Structure–Activity Relationships within Pharmaceutical Interactions and the Discovery of Molecular Targets
edited by
submission deadline 31 Oct 2024 | Viewed by 141 | Submission Open
Keywords: molecular dynamics; docking simulation; QSAR; moleular initiating event
(This special issue belongs to the Section Molecular Pharmacology)
New Insights into Male Infertility and Sperm Biology
edited by
submission deadline 31 Oct 2024 | Viewed by 140 | Submission Open
Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Biology)
Challenges in Molecularly Imprinted Materials
edited by
submission deadline 31 Oct 2024 | Viewed by 134 | Submission Open
Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization
(This special issue belongs to the Section Materials Science)
Nanoparticles as Regulators of Photosynthetic Performance
edited by
submission deadline 31 Oct 2024 | Viewed by 134 | Submission Open
Keywords: abiotic stress; nanoparticles; photosynthesis; chlorophyll fluorescence; signal molecules; antioxidant activity; chlorophyll fluorescence; photosynthetic machinery reactive oxygen species; thylakoid membranes; photosynthetic machinery; signal molecules
(This special issue belongs to the Section Molecular Nanoscience)
Drug Discovery and Novel Platelet Signaling in Thrombogenesis 2.0
edited by
submission deadline 31 Oct 2024 | Viewed by 133 | Submission Open
Keywords: platelet; thrombosis; hemostasis; drug discovery; signaling; occlusive disease; cardiovascular disease
(This special issue belongs to the Section Biochemistry)
Mitochondrial Biology: Novel Insights and Frontier Discoveries submission deadline 31 Oct 2024 | Viewed by 128 | Submission Open
Keywords: mitochondrial biology; mitochondrial disfunction; glycolysis; gluconeogenesis; urea cycle; fatty acid synthesis
(This special issue belongs to the Section Molecular Biology)
Natural Anticancer Molecules and Their Therapeutic Potential: 2nd Edition
edited by
submission deadline 31 Oct 2024 | Viewed by 126 | Submission Open
Keywords: natural product; leading compound; anticancer; potential cancer targets; signal transduction; apoptosis; enzymes; immunomodulatory; mechanisms of action; bioactivity-guided isolation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Latest Advances in Autoinflammation
edited by
submission deadline 31 Oct 2024 | Viewed by 125 | Submission Open
Keywords: autoinflammatory; innate immunity; inflammasome; recurrent fever; NLRP3; VEXAS; AOSD; interleukin-1 (IL-1); genetics; syndrome of undifferentiated recurrent fever (SURF); caspase; CAPS; anakinra; cryopirin
(This special issue belongs to the Section Molecular Immunology)
Single-Atom Catalysts for Small Molecule Transformation
edited by Aijuan Han
submission deadline 31 Oct 2024 | Viewed by 119 | Submission Open
Keywords: single-atom catalyst; small molecule transformation; rational design; applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Advances in Burn and Wound Healing
edited by
submission deadline 31 Oct 2024 | Viewed by 117 | Submission Open
Keywords: burn; wound; molecular mechanisms; cell signaling; growth factors; cytokines; extracellular matrix; angiogenesis; healing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanoformulations for the Treatment of Human Diseases
edited by Sergio Acin Martinez
submission deadline 31 Oct 2024 | Viewed by 117 | Submission Open
Keywords: nanomedicine; nanomaterials nanomedicine; liposomes; nanocrystal; polymeric nanoparticles
(This special issue belongs to the Section Molecular Nanoscience)
Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies
edited by Cecilia Zazueta
submission deadline 31 Oct 2024 | Viewed by 115 | Submission Open
Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Myocardial Fibrosis
edited by Andrea Sonaglioni
submission deadline 1 Nov 2024 | Viewed by 446 | Submission Open
Keywords: obesity; myocardial fibrosis; subclinical myocardial dysfunction; fibrotic remodelling; microRNAs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Defense Response to Microbial, Herbivorous, and Environmental Interactions
edited by
submission deadline 10 Nov 2024 | 5 articles | Viewed by 12904 | Submission Open
Keywords: plant pathogenic infections; insect pest damage; abiotic stress; plant/microbial chemical signaling; innate immunity; systemic acquired resistance (SAR); pathogen-related proteins; plant defense enzymes; plant growth hormones
(This special issue belongs to the Section Molecular Plant Sciences)
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