Metal-Based Compounds: Relevance for the Biomedical Field
A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".
Deadline for manuscript submissions: 15 September 2024 | Viewed by 5824
Special Issue Editors
Interests: chemistry of transition metal complexes; nanoparticles as drug delivery systems; antitumor activity
Interests: transition metal chemistry; biomolecules interactions; antitumor activity
Special Issue Information
Dear Colleagues,
The exciting research fields of Bioinorganic chemistry and Inorganic medicinal chemistry are in full expansion, providing new perspectives regarding the interaction of inorganic compounds with biological matrixes and their potential as therapeutic and diagnosis agents. Metal complexes, especially those containing transition metal ions, are valuable platforms for drug design and have proven their biological properties many times over, with important progress being made in obtaining new compounds with antitumor, antibacterial, antiviral and antifungal activity.
This Inorganics Special issue wishes to provide an overview on the current topics of interest in Inorganic chemistry with a focus on bioactive compounds. Original research articles as well as reviews are welcome, with the aim to highlight recent advances concerning the following issues:
- The role of metal ions in biological environments
- Synthesis, phisico-chemical characterization of metal complexes and evaluation of their biological and therapeutic potential
- The interaction of coordination and organometallic compounds with biological macromolecules, such as nucleic acids and proteins
- Coordination compounds as metallo-enzymes mimics
- Metallic and metal oxide nanoparticles as therapeutic and diagnosis agents
Dr. Tamara Topala
Prof. Dr. Luminita Simona Oprean
Dr. Andreea Elena Bodoki
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- transition metal complexes
- biomolecules interactions
- enzyme mimics
- therapeutic platforms
- diagnosis agents
- biological activity
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Evaluation of DNA and BSA binding, nuclease activity and anticancer properties of new Cu(II) and Ni(II) complexes with quinoline derived sulfonamides
Authors: Tamara Liana Topală; Ionel Fizeșan; Andreea Elena Petru; Alfonso Castiñeiras; Andreea Elena Bodoki; Luminița Simona Oprean; Marcos Escolano; Gloria Alzuet–Piña
Affiliation: Department of Inorganic Chemistry, Faculty of Pharmacy, Universitat de València, Valencia, Spain
Abstract: Four complexes of essential metal ions, Cu(II) and Ni(II), with the new sulfonamide ligand N-(pyridin-2-ylmethyl)quinoline-8-sulfonamide (HQSMR) were synthesized and physicochemically and structurally characterized. Complex [Cu(QSMR)Cl]n (2) consists in a polymeric chain formed by distorted square pyramidal units. In 2 the sulfonamide ligand acts as a bridge coordinating to one Cu(II) through its three N atoms and to another metal ion via one O atom of the sulfonamido group, while the pentacoordinate complex [Cu(QSMR)(C6H5COO)] (3) presents a highly distorted square pyramidal geometry. Complex [Ni(QSMR)(C6H5COO)(CH3OH)][Ni(QSMR)(CH3COO)(CH3OH)] (4) consists in two mononuclear entities, containing different anion coligands, either a benzoate or an acetate group. Both units exhibit a distorted octahedral geometry. The interaction of the complexes with CT-DNA was studied by means of UV-Vis and fluorescence spectroscopy, interestingly revealing that the Ni(II) complex presents the highest affinity towards the nucleic acid. Complexes 1 and 2 are able to cleave DNA. Both compounds show promising nuclease activity at relatively low concentrations, by mediating the production of reactive oxygen species (ROS). The interaction of the four complexes with bovine serum albumin (BSA) was also investigated, showing that the compounds can bind to serum proteins. The antitumor potential of complexes 1 and 2 was evaluated against the A549 lung adenocarcinoma cell line, revealing cytotoxic properties that were both dose and time dependent.
Title: Green-Synthesized Zinc Oxide/Silver Nanoparticles from Sophora pachycarpa for Anticancer Activity, Gene Expression Analysis, and Antibacterial Applications
Authors: Sobhan Mortazavi-Derazkola
Affiliation: Birjand University of Medical Sciences
Title: Coordination compounds of nickel(II) with 3,5–dibromo–salicylaldehyde: Structure and interaction with biomolecules
Authors: Georgios I Psarras; Ariadni Zianna; Antonios G Hatzidimitriou; George Psomas
Affiliation: Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, Greece
Abstract: Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O)2] (complex 3), and were characterized by various techniques. The crystal structure of complex 1 was determined by single–crystal X–ray crystallography. According to employed studying techniques, the complexes interact tightly with calf–thymus DNA by an intercalative manner. Furthermore, the compounds bind tightly and reversibly to human and bovine serum albumin.