Journal of Clinical Medicine

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Special Issue Information

Dear Colleagues,

Inflammatory Bowel Disease: looking to new horizons

Inflammatory bowel diseases (IBD) are characterised by active chronic inflammation in the gastrointestinal tract with huge morbidity for patients and large healthcare costs. IBD can be classified as Crohn’s disease (CD), ulcerative colitis (UC), or IBD unclassified (IBDU). Now seen as a global condition, prevalence of this incurable condition continues to increase. Whilst much is known about IBD, there remain many gaps in our understanding of the pathogenesis of IBD, variable approaches to the management of IBD, and inconsistent outcomes. This Collection Series aims to draw together articles focusing on current aspects of IBD and key aspects looming on the horizon. These might include therapeutic agents, such as the use of small molecules (JAK kinase inhibitors and S1P receptor modulators), and therapeutic approaches, such as treat-to-target or combination trials. Additional articles could focus on aspects of the pathogenesis of IBD (with regard to environmental factors, host immune responses, or the intestinal microbiome) and outcomes.

Prof. Dr. Laurent Peyrin-biroulet
Prof. Dr. Andrew Day
Guest Editors

Manuscript Submission Information

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Keywords

inflammatory bowel diseases
Crohn’s disease
ulcerative colitis
JAK kinase inhibitors
SIP receptor modulators
therapeutic approaches

Published Papers (1 paper)

Review

16 pages, 355 KiB

Open AccessReview

Evolution of a Pathogenic Microbiome

by Pui Yin Wong, Carmen Yip, Daniel A. Lemberg, Andrew S. Day and Steven T. Leach

J. Clin. Med. 2023, 12(22), 7184; https://doi.org/10.3390/jcm12227184 - 20 Nov 2023

Viewed by 1117

Abstract

The process of microbiome development arguably begins before birth. Vertical transmission of bacteria from the mother to the infant is a keystone event in microbiome development. Subsequent to birth, the developing microbiome is vulnerable to influence from a wide range of factors. Additionally, the microbiome can influence the health and development of the host infant. This intricate interaction of the gastrointestinal microbiome and the host has been described as both symbiotic and dysbiotic. Defining these terms, a symbiotic microbiome is where the microbiome and host provide mutual benefit to each other. A pathogenic microbiome, or more precisely a gastrointestinal microbiome associated with disease, is increasing described as dysbiotic. This review seeks to investigate the factors that contribute to evolving a disease-causing or ‘dysbiotic’ microbiome. This review covers the development of the gastrointestinal microbiome in infants, the interaction of the microbiome with the host, and its contribution to host immunity and investigates specific features of the gastrointestinal microbiome that are associated with disease. Full article

(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Inflammatory Bowel Disease)

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