The Molecular and Cellular Basis for Inflammatory Bowel Diseases (IBD)
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 177110
Special Issue Editors
Interests: inflammatory bowel disease; inflammation; gut vascular barrier; immune response; leukocyte trafficking; lipid mediators; colorectal cancer
Special Issues, Collections and Topics in MDPI journals
Interests: inflammatory bowel diseases
Special Issues, Collections and Topics in MDPI journals
Interests: lymphatic system; gut inflammation; virome; microbiota; resolution of inflammation; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last few years, substantial progress has been made in understanding the pathogenetic mechanisms of inflammatory bowel disease (IBD), specifically Crohn’s disease (CD) and ulcerative colitis (UC). Recent works have examined the concept that IBD could result from dysregulation of the intestinal barrier and a pathologic activation of the intestinal immune response toward several bacterial or viral antigens. This has been translated into newer, more effective therapies—biologic and molecular therapies—that have decreased the occurrence of flares, led to remission in more patients, and improved patients’ quality of life.
To date, several factors have been proposed to be involved in the pathogenesis of IBD, including antigen presentation and balance between the different T-cell subpopulations, altered microbiota, anomalies of immune regulation, and phagocytosis; nevertheless, new cellular and molecular targets are under investigation and novel therapeutic approaches have been developed accordingly.
This Special Issue aims to summarize the current knowledge on the cellular and molecular mechanisms behind the pathogenesis of IBD and IBD-related complications, focusing on promising and emerging targets, and linking pre-clinical and translational research with clinical studies.
We look forward for your contributions.
Prof. Dr. Silvio Danese
Prof. Laurent Peyrin-biroulet
Dr. Silvia D’Alessio
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Intestinal inflammation
- Immune-mediated disease
- Microbiota
- Leukocyte trafficking
- Pro-and anti-inflammatory mechanisms
- IBD-related complications