Clinical Advances in Chronic Obstructive Pulmonary Diseases in the Era of Precision Medicine

Dear Colleagues,

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is complex and heterogeneous with respect to its aetiology, clinical presentation, phenotypes, and biological mechanisms. To address this complexity in clinical practice, and to move further toward personalized and precision medicine, a strategy based on the identification and treatment of so-called "treatable traits" has been proposed. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a mechanistic level why certain individuals are at high risk. Genetics, omics, and network analysis have begun to be used to unravel the heterogeneity of COPD and diagnose people with particular pathobiologies. Treating COPD patients according to their unique pathophysiological abnormalities and identifying high-risk individuals will become much easier with the availability of larger data sets, more omics, and new analytical techniques. These methods hold significant potential for COPD risk assessment, early intervention, medication repurposing, and the creation of innovative treatment strategies. This Special Issue will address precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. Therefore, to move this field forward, we invite original research, perspectives, and state-of-the-art reviews on clinical advances in COPD.

Dr. Κonstantinos Bartziokas
Dr. Andriana I. Papaioannou
Guest Editors

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• personalized management
• treatment
• co-morbidities
• COPD exacerbation
• disease progression
• mortality
• pathogenesis
• airway inflammation
• biomarker