Dear Colleagues,

Chronic Traumatic Encephalopathy (CTE) was first described as the “punch drunk syndrome” that affected some boxers almost a century ago. Currently, CTE is defined as a neurodegenerative disease associated with repeated mild traumatic brain injury (TBI) or a single moderate or severe TBI. Over the past few decades, the understanding of the neuropathology of CTE has been growing. It is now time to focus on novel diagnostic and therapeutic strategies for CTE. It’s been suggested that CTE’s neuropathology includes p-tau, amyloid β (Aβ), and TDP-43; chronic neuroinflammation; axonal degeneration; degradation of white matter; and neuronal loss, in which the tau pathology is more specific, with less conflict between the studies. Even so, the complex pathology to the clinical presentations of CTE remains to be expanded and established. Moreover, CTE’s syndromes have been investigated widely, including headache, aggression, depression, cognitive impairment, dementia, etc. However, most of these syndromes are nonspecific to CTE, as they are also associated with other neurological and psychiatric disorders and conditions.

Recently, in order to diagnose CTE in vivo, a variety of diagnostic strategies have been investigated, including the identification of cerebrospinal fluid and blood biomarkers, development and application of various novel neuroimaging techniques, and improvement of clinical criteria. Furthermore, several preventive, therapeutic strategies for CTE have been studied such as the cis p-tau antibody, neurotrophic receptor ligands, as well as the hyperbaric oxygen therapy.

The Special Issue aims to solicit novel contributions to the current difficulties of improving diagnosis, prevention, and treatment of CTE, by also seeking manuscripts on its further pathologies and molecular and cellular regulations for CTE. 

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Chronic Traumatic Encephalopathy (CTE)
• Repetitive TBI
• Moderate or severe TBI
• Pathological CTE
• Biomarkers
• Neuroimage techniques
• Syndromes and clinical criteria
• Immunity therapy
• Preventive treatment