Injectable and Biodegradable Hydrogels for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1551

Special Issue Editor


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Guest Editor
Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland
Interests: materials engineering; polymers; biomaterials; hydrogels; nanofibers; electrospinning; drug delivery; tissue engineering and regenerative medicine (TERM)

Special Issue Information

Dear Colleagues,

Hydrogels have come a long way since Wichterle and Lim as a first described their potential for application in biomedical products more than 60 years ago. Injectable hydrogels create a great opportunity for modern treatment methods, making them more effective and less invasive. Injectable hydrogels are a great vehicle for the delivery of bioactive molecules or cells at target sites. Today, hydrogels are developed or used in various applications, such as cell scaffolds for cartilage or bone regeneration, drug delivery systems in oncology or antiadhesive barriers in general surgery. However, these materials still have a comparatively small impact on clinical practice. Despite the significant amount of R&D research, very few pass to clinical trials.

For this reason, the aim of this Special Issue entitled “Injectable and Biodegradable Hydrogels for Biomedical Applications” is to highlight the current trends in injectable hydrogel development, as well as show their possibilities and limitations. In this Special Issue, we welcome the submission of manuscripts concerning injectable hydrogels for drug or cell delivery and hydrogels for scaffolds. Research articles concerning stimuli-responsive hydrogels, conducive hydrogels, self-healing hydrogels, and novel hybrid materials containing hydrogels are especially welcome. We look forward to the submission of new results on injectable hydrogels, as well as critical reviews concerning the subject of the Special Issue.

Dr. Olga Urbanek
Guest Editor

Manuscript Submission Information

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Keywords

  • injectable hydrogels
  • stimuli-responsive hydrogels
  • conductive hydrogels
  • self-healing hydrogels
  • scaffolds
  • drug delivery

Published Papers (1 paper)

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Research

11 pages, 2697 KiB  
Article
Injectable Micro-Hydrogel for DNA Delivery: A Promising Therapeutic Platform
by Sunghyun Moon and Jong Bum Lee
J. Funct. Biomater. 2024, 15(3), 59; https://doi.org/10.3390/jfb15030059 - 1 Mar 2024
Viewed by 1162
Abstract
Utilizing the immune system as a strategy for disease prevention and treatment is promising, especially with dendritic cells (DCs) playing a central role in adaptive immune responses. The unique properties of DCs drive interest in developing materials for cell-based therapy and immune modulation. [...] Read more.
Utilizing the immune system as a strategy for disease prevention and treatment is promising, especially with dendritic cells (DCs) playing a central role in adaptive immune responses. The unique properties of DCs drive interest in developing materials for cell-based therapy and immune modulation. Injectable systems require syringe-compatible scaffolds, while hydrogels, like alginate, known for their programmability and biocompatibility, offer a versatile platform for immune medicine enhancement through easy preparation and room-temperature cross-linking. In this study, we synthesized alginate balls loaded with DCs or cytosine–phosphorothioate–guanine deoxyribonucleotide (CpG DNA) microparticles, aiming for long-term immune cell culture with potential immune stimulation effects. Encapsulated DCs exhibited proliferation within the alginate balls for up to 7 days, and CpG MPs were uniformly dispersed, which can facilitate uptake by DCs. This was supported by the result that DCs effectively phagocytosed CpG microparticles in a 2D environment. After the uptake of CpG MPs, the alginate balls with CpG-MP-uptaken DCs were synthesized successfully. The injectable properties of the alginate balls were easily modulated by adjusting the syringe needle gauges. This innovative strategy holds substantial promise for advancing medical treatments, offering effective and comfortable solutions for controlled immune modulation. Full article
(This article belongs to the Special Issue Injectable and Biodegradable Hydrogels for Biomedical Applications)
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