Photodynamic Therapy of Cancer, Microbes and Viruses

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Cancer Therapies".

Deadline for manuscript submissions: 16 August 2024 | Viewed by 1469

Special Issue Editor


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Guest Editor
Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia
Interests: carbon quantum dots; carbon nanomaterials; antimicrobial and antiviral plastics; photodynamic therapy of cancer and microbes
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Special Issue Information

Dear Colleagues,

Photodynamic therapy against various diseases is of great significance in biomedicine, and has therefore attracted much attention from researchers. Numerous problems arise during the photodynamic treatment of cancer, microbes, antibiotic-resistant super pathogens and viruses; therefore, these treatments require further development. Although numerous light-triggered nanoparticles and surfaces that release reactive oxygen species have been developed, their application levels are still very low. The main obstacles to their widespread application are their high price, low efficiency and high toxicity. Therefore, it is important for researchers to study the properties of photoactive nanoparticles themselves, as well as the mechanisms of interaction of reactive oxygen species with biological systems.

In this Special Issue, we aim to discuss different aspects of photoactive nanoparticles and surfaces acting mainly against tumors, microbes, viruses and biofilms. The main topics include the following:

  • The development of antitumor photoactive nanoparticles;
  • The development of antimicrobial photoactive nanoparticles;
  • The development of antiviral/anti-COVID photoactive nanoparticles;
  • The mechanisms of interactions between reactive oxygen species and super pathogens.

This Special Issue will be a collection of research and review papers discussing the most recent progress in subfields of medicine and natural and social sciences. We hope that it will be a valuable resource for a broad readership in these fields in this time of epidemy.

Prof. Dr. Zoran M. Marković
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photodynamic therapy
  • reactive oxygen species
  • photosensitizer
  • photoactive nanoparticles and surfaces

Published Papers (1 paper)

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Research

18 pages, 5077 KiB  
Article
Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films
by Zoran M. Marković, Milica D. Budimir Filimonović, Dušan D. Milivojević, Janez Kovač and Biljana M. Todorović Marković
J. Funct. Biomater. 2024, 15(3), 73; https://doi.org/10.3390/jfb15030073 - 17 Mar 2024
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Abstract
The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria [...] Read more.
The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms. Full article
(This article belongs to the Special Issue Photodynamic Therapy of Cancer, Microbes and Viruses)
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