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Special Issues
Biomaterials for Diagnostic, Therapeutic, and Theranostic Applications
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Biomaterials for Diagnostic, Therapeutic, and Theranostic Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3384

Special Issue Editors

Dr. Jianrong Wu

E-Mail Website
Guest Editor
Department of Ultrasound in Medicine, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Interests: biomaterials; drug delivery; cancer therapy; nanomedicine; theranostics; mesoporous silica
Prof. Dr. Yuanyi Zheng

E-Mail Website
Guest Editor
1. Department of Ultrasound in Medicine, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
2. State Key Laboratory of Oncogenes and Related Genes, School of Medicine, Shanghai Jiao Tong University, Shanghai 200233, China
Interests: ultrasound-based biomedicine; ultrasound molecular imaging; theranostics; biomaterials; brain science; magnetic actuation systems

Special Issue Information

Dear Colleagues,

Theranostic formulations, integrating both diagnostic and therapeutic functions into a single platform, hold great potential for precision medicines. Recently, new advances in the bio-application of biomaterials are being reported for diagnostic, therapeutic, and theranostic applications. With the rapid development of emerging techniques of materials chemistry, biomaterials-based nanoplatforms have been strategically integrated with imaging contrast agents and therapeutic agents for various molecular imaging modalities including fluorescence imaging, magnetic resonance imaging, ultrasound imaging, or multimodal imaging, as well as for various therapeutic approaches including chemotherapy, gene therapy, hyperthermia therapy, photodynamic therapy, radiation therapy, or combination therapy, even imaging-guided therapy. The most encouraging aspect of these new developments is that some of the current research efforts start to implement the latest concepts of disease, that is, theranostics is evolving to incorporate aspects of both molecular imaging as well as personalized therapy.

The aim of this Special Issue is to develop more advanced biomaterials-based theranostics agents for anticancer, antibacterial, brain disease, and other relative biomedical applications. Both promising original scientific investigations and exhaustive reviews concerning this field are welcome. The scope is not restricted to biomaterials for theranostics; contributions on similar topics are also welcome.

The Special Issue contents are expected to include but not be limited to:

  • Biomaterials for theranostics;
  • Biomaterials for disease diagnosis;
  • Biomaterials for treatments;
  • Advanced biomaterials for healthcare applications.

Dr. Jianrong Wu
Prof. Dr. Yuanyi Zheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • theranostics
  • diagnosis
  • caner
  • antibacterial
  • molecular imaging
  • nanomedicine
  • biocompatibility

Published Papers (2 papers)

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Research

15 pages, 4174 KiB  
Article
Gold Nanoparticle-Based Colorimetric and Fluorescent Dual-Mode Lateral Flow Immunoassay for SARS-CoV-2 Detection
by Ying Gan, Hefan Zhang, Jing Liu, Fuqin He, Fengheng Li, Ao Li, Man Xing, Dongming Zhou, Shan-Yu Fung and Hong Yang
J. Funct. Biomater. 2024, 15(3), 58; https://doi.org/10.3390/jfb15030058 - 27 Feb 2024
Viewed by 1221
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused the COVID-19 pandemic, impacting the global economy and medical system due to its fast spread and extremely high infectivity. Efficient control of the spread of the disease relies on a fast, accurate, and convenient [...] Read more.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused the COVID-19 pandemic, impacting the global economy and medical system due to its fast spread and extremely high infectivity. Efficient control of the spread of the disease relies on a fast, accurate, and convenient detection system for the early screening of the infected population. Although reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is the gold-standard method for SARS-CoV-2 RNA analysis, it has complex experimental procedures and relies on expensive instruments and professional operators. In this work, we proposed a simple, direct, amplification-free lateral flow immunoassay (LFIA) with dual-mode detection of SARS-CoV-2 RNA via direct visualization as well as fluorescence detection. The viral RNA was detected by the designed DNA probes to specifically hybridize with the conserved open reading frame 1ab (ORF1ab), envelope protein (E), and nucleocapsid (N) regions of the SARS-CoV-2 genome to form DNA–RNA hybrids. These hybrids were then recognized by the dual-mode gold nanoparticles (DMNPs) to produce two different readout signals. The fluorescence characteristics of different sizes of GNPs were explored. Under the optimized conditions, the LFIA presented a linear detection range of 104–106 TU/mL with a limit of detection (LOD) of 0.76, 1.83, and 2.58 × 104 TU/mL for lentiviral particles carrying SARS-CoV-2 ORF1ab, E, and N motifs, respectively, in the fluorescent mode, which was up to 10 times more sensitive than the colorimetric mode. Furthermore, the LFIA exhibited excellent specificity to SARS-CoV-2 in comparison with other respiratory viruses. It could be used to detect SARS-CoV-2 in saliva samples. The developed LFIA represents a promising and convenient point-of-care method for dual-mode, rapid detection of SARS-CoV-2, especially in the periods with high infectivity. Full article
(This article belongs to the Special Issue Biomaterials for Diagnostic, Therapeutic, and Theranostic Applications)
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11 pages, 3588 KiB  
Article
Macrophages Loaded with Fe Nanoparticles for Enhanced Photothermal Ablation of Tumors
by Lei Yu, Shuntao Zhu, Kun Qin, Xueyu Fan and Lu An
J. Funct. Biomater. 2022, 13(3), 94; https://doi.org/10.3390/jfb13030094 - 14 Jul 2022
Cited by 7 | Viewed by 1619
Abstract
Magnetic iron nanoparticle-based theranostics agents have attracted much attention due to their good magnetism and biocompatibility. However, efficiently enriching tumors with iron nanoparticles to enhance the treatment effect remains a pressing challenge. Herein, based on the targeting and high phagocytosis of macrophages, an [...] Read more.
Magnetic iron nanoparticle-based theranostics agents have attracted much attention due to their good magnetism and biocompatibility. However, efficiently enriching tumors with iron nanoparticles to enhance the treatment effect remains a pressing challenge. Herein, based on the targeting and high phagocytosis of macrophages, an Fe nanoparticle-loaded macrophage delivery system was designed and constructed to efficiently deliver iron nanoparticles to tumors. Hydrophilic Fe@Fe3O4 nanoparticles with a core-shell structure were synthesized by pyrolysis and ligand exchange strategy. Subsequently, they were loaded into macrophages (RAW264.7 cells) using a co-incubation method. After loading into RAW264.7, the photothermal performance of Fe@Fe3O4 nanoparticles were significantly enhanced. In addition, Fe@Fe3O4 nanoparticles loaded into the macrophage RAW264.7 (Fe@Fe3O4@RAW) exhibited a good T2-weighted MRI contrast effect and clear tumor imaging in vivo due to the tumor targeting tendency of macrophages. More importantly, after being intravenously injected with Fe@Fe3O4@RAW and subjected to laser irradiation, the tumor growth was effectively inhibited, indicating that macrophage loading could enhance the tumor photothermal ablation ability of Fe@Fe3O4. The macrophage mediated delivery strategy for Fe@Fe3O4 nanoparticles was able to enhance the treatment effect, and has great potential in tumor theranostics. Full article
(This article belongs to the Special Issue Biomaterials for Diagnostic, Therapeutic, and Theranostic Applications)
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