Journal of Personalized Medicine

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Special Issue Editors

Dr. Yang Jiao

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Guest Editor

The 7th Medical Center, Chinese PLA General Hospital, Beijing, China
Interests: tissue engineering; biomaterials; implant surface modification; wound healing; antibacterial/anti-inflammatory nanomaterials; redox biology

Dr. Yang Yu

E-Mail Website
Guest Editor

School and Hospital of Stomatology at Shandong University, Jinan, China
Interests: periodontal tissue regeneration; preconditioning of stem cells before transplantation; immunoregulation

Special Issue Information

Dear Colleagues,

Regenerative medicine is a promising branch of medicine that brings new hopes for the treatment of damaged or lost tissues to promote tissue repair and regeneration.

Various kinds of new technologies have been used over the past decades. These include single-cell and spatial sequencing, multi-omics, genetic animal models, high-dimensional flow cytometry, molecular biological approaches, single-particle analysis, cell-sorting technologies, tissue engineering strategies, stem cell transplantations, as well as targeted and controllable drug delivery methodologies.

The aim of the Special Issue is to bring together the latest quality articles on stem cell-based approaches to achieving regenerative medicine in the research field of dentistry, orthopaedics, wound healing, etc. We invite original research, reviews, commentary articles, and perspectives that focus on the latest research progress on stem cells, osteoimmunology, inflammation, and other microenvironments in tissue regeneration, as well as investigations into molecular mechanisms and clinical translational research.

Dr. Yang Jiao
Dr. Yang Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

personalized medicine
regenerative medicine
tissue engineering
tissue regeneration
stem cells
osteoimmunology
nanomedicine
translational research

Published Papers (2 papers)

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Review

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14 pages, 877 KiB

Open AccessReview

Mesenchymal Stromal Cell Therapy for Thoracic Surgeons: An Update

by Francesco Petrella, Enrico Mario Cassina, Lidia Libretti, Emanuele Pirondini, Federico Raveglia and Antonio Tuoro

J. Pers. Med. 2023, 13(12), 1632; https://doi.org/10.3390/jpm13121632 - 22 Nov 2023

Viewed by 970

Abstract

Stem cells are undifferentiated cells presenting extensive self-renewal features and the ability to differentiate “in vitro” and “in vivo” into a range of lineage cells, like chondrogenic, osteogenic and adipogenic lineages when cultured in specific inducing media. Two major domains of clinical applications of stem cells in thoracic surgery have been investigated: regenerative medicine, which is a section of translational research in tissue engineering focusing on the replacement, renewal or regeneration of cells, tissues and organs to re-establish damaged physiologic functions; drug loading and delivery, representing a new branch proposing stem cells as carriers to provide selected districts with anti-cancer agents for targeted treatments. Full article

(This article belongs to the Special Issue Stem Cells-Based Approaches in Regenerative Medicine)

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Other

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10 pages, 2005 KiB

Open AccessCase Report

A Single Intradermal Injection of Autologous Adipose-Tissue-Derived Stem Cells Rejuvenates Aged Skin and Sharpens Double Eyelids

by Masamitsu Ichihashi, Masaki Tanaka, Takashi Iizuka, Hiroko Totsuka, Ekuko Tominaga, Yuka Hitomi, Hideya Ando, Takahiro Nishikata and Ken-Ichi Mizutani

J. Pers. Med. 2023, 13(7), 1162; https://doi.org/10.3390/jpm13071162 - 20 Jul 2023

Cited by 1 | Viewed by 1723

Abstract

Facial skin aging is the most visible manifestation of aging in the body. In this study, we aimed to rejuvenate aging skin via a one-time intradermal injection of autologous adipose-derived stem cells (ADSCs). Eight patients were enrolled for study. Photographs of patients taken immediately before and 1, 3, 6, and 12 months after ADSC injections were comparatively evaluated for visible skin manifestations. ADSCs were cultured from the abdominal-skin-derived subcutaneous fat tissue, and 1 × 108 cultured ADSCs were injected intradermally into the facial skin. Cultured myoblasts were incubated with the supernatant derived from ADSCs, and the effect was evaluated via glucose consumption and lactic acid production in the medium. Eight cases showed the shallowing and disappearance of wrinkles, including those of the glabella, lower eyelids, crow`s feet, and forehead and nasolabial grooves, a month to several months after treatment. Double eyelids became prominent, and facial pores significantly reduced in size. These effects lasted for over one year. Myoblasts cultured in the presence of an ADSC-derived exosome were activated compared to that of ADSCs cultured without supernatant. The result supports the role of muscle in ADSC skin rejuvenation. The present study first reports that a single intradermal administration of cultured ADSCs rejuvenates aged facial skin over the course of one year. Further, patients exhibited definite double eyelids and pore shrinkage, strongly indicating the active involvement of muscle, which was supported by an in vitro study. Our study also suggested the important role of biological factors delivered from injected stem cells, although the detailed mechanism of rejuvenation effects of ADSC skin injection remains to be clarified. Full article

(This article belongs to the Special Issue Stem Cells-Based Approaches in Regenerative Medicine)

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