Progress on Personalized Diagnosis and Treatment of Osteoarthritis

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1453

Special Issue Editors


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Guest Editor
Department of Public Health, Rehabilitation Unit, University of Naples Federico II, 80131 Naples, Italy
Interests: physical medicine and rehabilitation; musculoskeletal rehabilitation; sport rehabilitation; musculoskeletal ultrasound; ultrasound-guided injections; interventional physiatry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Public Health, Rehabilitation Unit, University of Naples Federico II, 80131 Naples, Italy
Interests: physical medicine and rehabilitation; musculoskeletal rehabilitation; neurological rehabilitation; sports rehabilitation; musculoskeletal ultrasound; ultrasound-guided injections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Osteoarthritis (OA) is a chronic, multifactorial disease affecting the joint and the surrounding tissues, primarily leading to progressive damage to articular cartilage and, subsequently, to the subchondral bone and surrounding synovial structures.

The overall worldwide prevalence of hip and knee OA is around 300 million. A report from the Global Burden of Disease in 2010 explored the burden of hip and knee OA, comparing both conditions with other diseases, and found that hip and knee OA represents one of the leading causes of global disability.

Given the multifactorial nature of OA, a proper evaluation of both non-modifiable (age, sex, genetics, etc.) and modifiable factors (smoking, alcohol consumption, diet, physical activity, etc.) is fundamental to establish a tailored treatment protocol.

In recent years, significant research advances have been made regarding more accurate diagnosis and effective treatment options for OA, particularly addressing the factors that contribute to its different phenotypes.

In this Special Issue, we are pleased to invite researchers with expertise in the field to submit high-quality articles or reviews related to new approaches for the diagnosis and treatment of OA.

Dr. Domiziano Tarantino
Dr. Bruno Corrado
Guest Editors

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Keywords

  • osteoarthritis
  • knee osteoarthritis
  • hip osteoarthritis
  • osteoarthritis diagnosis
  • osteoarthritis treatment
  • conservative osteoarthritis treatment
  • surgical osteoarthritis treatment

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Published Papers (1 paper)

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Research

12 pages, 3998 KiB  
Article
The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Retrospective Study
by Domiziano Tarantino, Alfonso Maria Forte, Antonio Picone, Felice Sirico and Carlo Ruosi
J. Pers. Med. 2024, 14(8), 784; https://doi.org/10.3390/jpm14080784 - 24 Jul 2024
Viewed by 1046
Abstract
Knee osteoarthritis (KOA) is a progressive and multifactorial disease that leads to joint pain, muscle weakness, physical disability, and decreased quality of life. In KOA, the quantity of hyaluronic acid (HA) and the molecular weight (MW) are decreased, leading to joint pain due [...] Read more.
Knee osteoarthritis (KOA) is a progressive and multifactorial disease that leads to joint pain, muscle weakness, physical disability, and decreased quality of life. In KOA, the quantity of hyaluronic acid (HA) and the molecular weight (MW) are decreased, leading to joint pain due to increased wear of the knee articular cartilage. Arthrogenic muscle inhibition, which is usually found in patients with KOA, is associated with joint inflammation, pain, and swelling, also causing muscle atrophy, primarily of the anterior thigh muscles, and hindering the rehabilitation process. The aim of our work was to determine if a single HA infiltration could minimize the effects of arthrogenic muscle inhibition in patients with KOA in the short term, using isokinetic dynamometry to evaluate the strength of the knee extensor and flexor muscles of the thigh. Thirty patients with KOA who underwent both clinical and isokinetic assessment, and that received a single injection of HA, were retrospectively included. Our results showed that a single intra-articular injection of HA significantly reduces pain and improves joint function at four weeks, while non-statistically significant improvements were observed for the reference isokinetic parameter (maximum torque) at both 90°/s and 180°/s. Further high-quality studies are necessary to confirm the results of our study. Full article
(This article belongs to the Special Issue Progress on Personalized Diagnosis and Treatment of Osteoarthritis)
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