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9.6
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Journals
Marine Drugs
Special Issues
Natural Products Research: Selected Papers from ISCNP31 & ICOB11
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Natural Products Research: Selected Papers from ISCNP31 & ICOB11

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1939

Special Issue Editors

Prof. Dr. Valeria Costantino

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Montesano 149, 80131 Naples, Italy
Interests: isolation and stereostructural elucidation of new leads compounds in anti-inflammatory and anti-cancer drug discovery; exploration of the QQ and the QS system in bacteria symbiotic with sponges with the goal to create novel leads in antibacterial drug discovery; cyanobacteria as source of novel lead compounds and toxins
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Raffaele Riccio

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Italy
Interests: chemistry of bioactive natural products from marine and terrestrial sources; approaches to the stereochemical determination of organic molecules by NMR and computational methods; target identification of bioactive natural products and investigation of ligand–receptor interactions by NMR and MS techniques, combined with computational tools
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Francesco Nicotra

E-Mail Website
Guest Editor
Department of Biotechnology and Biosciences, Universita degli Studi di Milano—Bicocca, Milan, Italy
Interests: organic chemistry; organic and biomolecular chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

The Italian chemical community has a long tradition in the chemistry of natural products, both of terrestrial and marine origin, as well as in the investigation and preservation of both terrestrial and marine biodiversity. This conference ISCNP31 & ICOB11 (https://www.iscnp31-icob11.org/) will be a chance to present your recent results and ideas in the field of natural products taking advantage of a vibrant and international community of scientists.

We encourage you to submit your recent results in the field of natural products, in particular novel mechanism of action, molecules, biomaterials, and approach to the synthesis of natural products. 

The event is supported by MDPI’s open access journals Marine Drugs and Molecules, so this will be a Joint Special Issue. You can publish by selecting one of the two journals.

We look forward to receiving your research papers and welcoming you to this conference.

Please contact us if you have any questions: [email protected]

You may choose our Joint Special Issue in Molecules.

Prof. Dr. Valeria Costantino
Prof. Dr. Raffaele Riccio
Prof. Dr. Francesco Nicotra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • bioactivity
  • toxin
  • bioinformatic analyses
  • biomaterials
  • natural products in cosmetic
  • natural products in food and supplements
  • biodiversity
  • chemical ecology
  • drug discovery

Published Papers (1 paper)

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Research

12 pages, 2305 KiB  
Article
Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A
by Alessandra Capuano, Gilda D’Urso, Michela Aliberti, Dafne Ruggiero, Stefania Terracciano, Carmen Festa, Alessandra Tosco, Maria Giovanna Chini, Gianluigi Lauro, Giuseppe Bifulco and Agostino Casapullo
Mar. Drugs 2024, 22(1), 41; https://doi.org/10.3390/md22010041 - 11 Jan 2024
Cited by 1 | Viewed by 1424
Abstract
Mass spectrometry-based chemical proteomic approaches using limited proteolysis have become a powerful tool for the identification and analysis of the interactions between a small molecule (SM) and its protein target(s). Gracilioether A (GeA) is a polyketide isolated from a marine sponge, for which [...] Read more.
Mass spectrometry-based chemical proteomic approaches using limited proteolysis have become a powerful tool for the identification and analysis of the interactions between a small molecule (SM) and its protein target(s). Gracilioether A (GeA) is a polyketide isolated from a marine sponge, for which we aimed to trace the interactome using this strategy. DARTS (Drug Affinity Responsive Target Stability) and t-LiP-MS (targeted-Limited Proteolysis-Mass Spectrometry) represented the main techniques used in this study. DARTS was applied on HeLa cell lysate for the identification of the GeA target proteins, and t-LiP-MS was employed to investigate the protein’s regions involved in the binding with GeA. The results were complemented through the use of binding studies using Surface Plasmon Resonance (SPR) and in silico molecular docking experiments. Ubiquitin carboxyl-terminal hydrolase 5 (USP5) was identified as a promising target of GeA, and the interaction profile of the USP5-GeA complex was explained. USP5 is an enzyme involved in the pathway of protein metabolism through the disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. This activity is connected to different cellular functions concerning the maintenance of chromatin structure and receptors and the degradation of abnormal proteins and cancerogenic progression. On this basis, this structural information opens the way to following studies focused on the definition of the biological potential of Gracilioether A and the rational development of novel USP5 inhibitors based on a new structural skeleton. Full article
(This article belongs to the Special Issue Natural Products Research: Selected Papers from ISCNP31 & ICOB11)
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