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Special Issue "Marine Fish Endocrine Disruption"

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 January 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Alfonsa García Ayala

Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 3100 Murcia, Spain
Interests: endocrine disruptors; marine fish; hermaphrodite; immune response; reproduction
Guest Editor
Dr. Elena Chaves-Pozo

Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n. Puerto de Mazarrón, 30860 Murcia, Spain
Interests: immune-reproductive responses; marine fish; viral transmission through the gonad; endocrine disruption

Special Issue Information

Dear Colleagues,

Endocrine disruptors (EDs) are a structurally diverse group of compounds that may adversely affect the health of humans, wildlife and fisheries, or their progenies, through their interaction with the endocrine system. Over the past decade, the list of chemicals known to have endocrine disrupting functions has dramatically increased. EDs have both synthetic and natural sources, among them organic chemicals used heavily in the past, especially in industry and agriculture, and others currently used as human and veterinary pharmaceuticals. EDs are resistant to environmental degradation and are considered ubiquitous contaminants as many have the ability to bioaccumulate and biomagnify in different environmental compartments, including marine biota. Thus, EDs range across all continents and oceans. The biological potency of EDs is higher than that of natural hormones, so even very low environmental concentrations may be sufficient to have detrimental biological effects.

EDs cause disruption by altering normal hormone levels, inhibiting or stimulating the production and metabolism of hormones, or by changing the way hormones travel through the body, thus affecting the functions that these hormones control. And since hormones control all aspects of physiology throughout the lifespan, the same can be expected from EDs. Many known EDs are estrogenic, affecting particularly reproductive functions and early life survival of fish and jeopardising whole populations. Moreover, studies on steroid synthesis and metabolism and on the possible effects of EDs on functions other than reproduction, including the immune response and growth, may help identify specific targets for endocrine disruption in marine environments. Most of the studies on the biological effects and mechanisms of action of EDs on marine organisms involve fish while studies of invertebrates are most limited in number. More data is needed to expand the list of tissues affected by EDs, and more effort is needed to identify and classify the dysfunctions they cause in marine species used as sentinels in environmental and monitoring studies, as commercial food and/or as model species.

To determine the potential impact or risk of EDs, in vivo approaches during endocrine-sensitive life stages in whole animal models are preferred. However, in vitro screening assays may still be very helpful for determining the exact mechanisms through which EDs interfere with different parts of the endocrine system. The efficacy of ED testing programmes could be enhanced by using emergent technologies in the areas of genomics and computational biology, thus providing mechanistic insights concerning exposure and possible adverse effects in animals.

As the Guest Editors, we would like to invite scientists to report their findings in the field of marine fish endocrine disruption.

Prof. Dr. Alfonsa García Ayala
Dr. Elena Chaves Pozo
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


Keywords

  • marine endocrine disruptors
  • marine species
  • model aquatic species
  • proteomic, genomic and epigenetic
  • molecular and cellular biology
  • endocrine systems
  • reproduction
  • biology of specimens

Published Papers (5 papers)

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Research

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Open AccessArticle Single and Competitive Adsorption of 17α-Ethinylestradiol and Bisphenol A with Estrone, β-Estradiol, and Estriol onto Sediment
Mar. Drugs 2014, 12(3), 1349-1360; doi:10.3390/md12031349
Received: 19 November 2013 / Revised: 15 January 2014 / Accepted: 13 February 2014 / Published: 7 March 2014
Cited by 2 | PDF Full-text (878 KB) | HTML Full-text | XML Full-text
Abstract
The competitive adsorption of bisphenol A (BPA) and17α-ethinylestradiol (EE2) with different endocrine disrupting compounds (EDCs), such as estrone (E1), β-estradiol (E2), and estriol (E3) was investigated in the water-sediment system. The primary and interaction effects of coexisted EDCs on the adsorption of [...] Read more.
The competitive adsorption of bisphenol A (BPA) and17α-ethinylestradiol (EE2) with different endocrine disrupting compounds (EDCs), such as estrone (E1), β-estradiol (E2), and estriol (E3) was investigated in the water-sediment system. The primary and interaction effects of coexisted EDCs on the adsorption of BPA and EE2 were studied in binary and multiple systems. The adsorption selectivity of sediment at different initial concentrations of EDCs was also considered, based on the distribution coefficient (β). In binary systems, coexisted EDCs exhibited a positive effect on the adsorption of BPA, while E3 showed a negative effect on the adsorption of EE2. In ternary systems, the interaction of E1*E3 and E2*BPA showed a synergistic effect on the sorption of BPA and EE2, respectively. In quaternary systems, the interaction of E1*E2*E3 showed a synergistic effect on the adsorption of both BPA and EE2. In the quinary system, coexisted EDCs all showed an antagonistic effect on the adsorption of BPA and EE2, which indicated that the coexisted EDCs competed for adsorption with BPA and EE2. EDCs in the E2-EE2-BPA system presented a superior selectivity of sediment with β values of 43.48–87.86. The order of sediment selectivity (E1 > EE2 > E2 > E3 > BPA) in binary systems was in agreement with EDCs’ adsorption capacity, which suggested that the adsorption was dominated by partition adsorption. Full article
(This article belongs to the Special Issue Marine Fish Endocrine Disruption)
Open AccessArticle Transcriptional Changes Caused by Bisphenol A in Oryzias javanicus, a Fish Species Highly Adaptable to Environmental Salinity
Mar. Drugs 2014, 12(2), 983-998; doi:10.3390/md12020983
Received: 10 December 2013 / Revised: 6 January 2014 / Accepted: 6 February 2014 / Published: 14 February 2014
Cited by 2 | PDF Full-text (725 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The Javanese medaka, Oryzias javanicus, is a fish highly adaptable to various environmental salinities. Here, we investigated the effects of the environmental pollutant bisphenol A (BPA; an endocrine disrupting chemical) on gene expression levels in this species acclimated to different salinities. [...] Read more.
The Javanese medaka, Oryzias javanicus, is a fish highly adaptable to various environmental salinities. Here, we investigated the effects of the environmental pollutant bisphenol A (BPA; an endocrine disrupting chemical) on gene expression levels in this species acclimated to different salinities. Using cDNA microarrays, we detected the induction of differential expression of genes by BPA, and compared the transcriptional changes caused by chemical exposure at different salinities. There were marked transcriptional changes induced by BPA between treatments. While 533 genes were induced by a factor of more than two when O. javanicus was exposed to BPA in seawater, only 215 genes were induced in freshwater. Among those genes, only 78 were shared and changed significantly their expression in both seawater and freshwater. Those genes were mainly involved in cellular processes and signaling pathway. We then categorized by functional group genes specifically induced by BPA exposure in seawater or freshwater. Gene expression changes were further confirmed in O. javanicus exposed to various concentrations of BPA, using quantitative real-time reverse transcription PCR based on primer sets for 28 selected genes. Full article
(This article belongs to the Special Issue Marine Fish Endocrine Disruption)
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Open AccessArticle The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish
Mar. Drugs 2013, 11(12), 4973-4992; doi:10.3390/md11124973
Received: 17 October 2013 / Revised: 21 November 2013 / Accepted: 22 November 2013 / Published: 11 December 2013
Cited by 6 | PDF Full-text (891 KB) | HTML Full-text | XML Full-text
Abstract
Pollutants have been reported to disrupt the endocrine system of marine animals, which may be exposed through contaminated seawater or through the food chain. Although 17α-ethynylestradiol (EE2), a drug used in hormone therapies, is widely present in the aquatic environment, [...] Read more.
Pollutants have been reported to disrupt the endocrine system of marine animals, which may be exposed through contaminated seawater or through the food chain. Although 17α-ethynylestradiol (EE2), a drug used in hormone therapies, is widely present in the aquatic environment, current knowledge on the sensitivity of marine fish to estrogenic pollutants is limited. We report the effect of the dietary intake of 5 µg EE2/g food on different processes of testicular physiology, ranging from steroidogenesis to pathogen recognition, at both pre-spermatogenesis (pre-SG) and spermatogenesis (SG) reproductive stages, of gilthead seabream (Sparus aurata L.), a marine hermaphrodite teleost. A differential effect between pre-SG and SG specimens was detected in the sex steroid serum levels and in the expression profile of some steroidogenic-relevant molecules, vitellogenin, double sex- and mab3-related transcription factor 1 and some hormone receptors. Interestingly, EE2 modified the expression pattern of some immune molecules involved in testicular physiology. These differences probably reflect a developmental adjustment of the sensitivity to EE2 in the gilthead seabream gonad. Full article
(This article belongs to the Special Issue Marine Fish Endocrine Disruption)
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Review

Jump to: Research

Open AccessReview Mugilid Fish Are Sentinels of Exposure to Endocrine Disrupting Compounds in Coastal and Estuarine Environments
Mar. Drugs 2014, 12(9), 4756-4782; doi:10.3390/md12094756
Received: 1 April 2014 / Revised: 11 August 2014 / Accepted: 27 August 2014 / Published: 12 September 2014
Cited by 4 | PDF Full-text (948 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Effects on fish reproduction can result from a variety of toxicity mechanisms first operating at the molecular level. Notably, the presence in the environment of some compounds termed endocrine disrupting chemicals (EDCs) can cause adverse effects on reproduction by interfering with the [...] Read more.
Effects on fish reproduction can result from a variety of toxicity mechanisms first operating at the molecular level. Notably, the presence in the environment of some compounds termed endocrine disrupting chemicals (EDCs) can cause adverse effects on reproduction by interfering with the endocrine system. In some cases, exposure to EDCs leads to the animal feminization and male fish may develop oocytes in testis (intersex condition). Mugilid fish are well suited sentinel organisms to study the effects of reproductive EDCs in the monitoring of estuarine/marine environments. Up-regulation of aromatases and vitellogenins in males and juveniles and the presence of intersex individuals have been described in a wide array of mullet species worldwide. There is a need to develop new molecular markers to identify early feminization responses and intersex condition in fish populations, studying mechanisms that regulate gonad differentiation under exposure to xenoestrogens. Interestingly, an electrophoresis of gonad RNA, shows a strong expression of 5S rRNA in oocytes, indicating the potential of 5S rRNA and its regulating proteins to become useful molecular makers of oocyte presence in testis. Therefore, the use of these oocyte markers to sex and identify intersex mullets could constitute powerful molecular biomarkers to assess xenoestrogenicity in field conditions. Full article
(This article belongs to the Special Issue Marine Fish Endocrine Disruption)
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Open AccessReview Effects of Estrogens and Estrogenic Disrupting Compounds on Fish Mineralized Tissues
Mar. Drugs 2014, 12(8), 4474-4494; doi:10.3390/md12084474
Received: 1 April 2014 / Revised: 17 July 2014 / Accepted: 30 July 2014 / Published: 15 August 2014
Cited by 4 | PDF Full-text (569 KB) | HTML Full-text | XML Full-text
Abstract
Estrogens play well-recognized roles in reproduction across vertebrates, but also intervene in a wide range of other physiological processes, including mineral homeostasis. Classical actions are triggered when estrogens bind and activate intracellular estrogen receptors (ERs), regulating the transcription of responsive genes, but [...] Read more.
Estrogens play well-recognized roles in reproduction across vertebrates, but also intervene in a wide range of other physiological processes, including mineral homeostasis. Classical actions are triggered when estrogens bind and activate intracellular estrogen receptors (ERs), regulating the transcription of responsive genes, but rapid non-genomic actions initiated by binding to plasma membrane receptors were recently described. A wide range of structurally diverse compounds from natural and anthropogenic sources have been shown to interact with and disrupt the normal functions of the estrogen system, and fish are particularly vulnerable to endocrine disruption, as these compounds are frequently discharged or run-off into waterways. The effect of estrogen disruptors in fish has mainly been assessed in relation to reproductive endpoints, and relatively little attention has been given to other disruptive actions. This review will overview the actions of estrogens in fish, including ER isoforms, their expression, structure and mechanisms of action. The estrogen functions will be considered in relation to mineral homeostasis and actions on mineralized tissues. The impact of estrogenic endocrine disrupting compounds on fish mineralized tissues will be reviewed, and the potential adverse outcomes of exposure to such compounds will be discussed. Current lacunae in knowledge are highlighted along with future research priorities. Full article
(This article belongs to the Special Issue Marine Fish Endocrine Disruption)
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