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Surface Modification and Assembly of Magnetic Nanoparticle Materials

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (31 March 2011) | Viewed by 9774

Special Issue Editor

Department of Nanobiotechnology, Instititute for Biologocially Inspired Materials, University of Natural Resources and Life Sciences Vienna, Muthgasse 11-II, A-1190 Vienna, Austria
Interests: colloidal science; surface science; liquid interfaces; nanoscience; nanoparticles; lipid membranes; polymer brushes; biointerfaces; biosensors
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Article
Efficacy and Durability in Direct Labeling of Mesenchymal Stem Cells Using Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Organosilica, Dextran, and PEG Coatings
by Yi-Xiang J. Wang, Thibault Quercy-Jouvet, Hao-Hao Wang, Ak-Wai Li, Chun-Pong Chak, Shouhu Xuan, Lin Shi, De-Feng Wang, Siu-Fung Lee, Ping-Chung Leung, Clara B. S. Lau, Kwok-Pui Fung and Ken Cham-Fai Leung
Materials 2011, 4(4), 703-715; https://doi.org/10.3390/ma4040703 - 07 Apr 2011
Cited by 26 | Viewed by 9196
Abstract
We herein report a comparative study of mesenchymal stem cell (MSC) labeling using spherical superparamagnetic iron oxide (SPIO) nanoparticles containing different coatings, namely, organosilica, dextran, and poly(ethylene glycol) (PEG). These nanomaterials possess a similar SPIO core size of 6–7 nm. Together with their [...] Read more.
We herein report a comparative study of mesenchymal stem cell (MSC) labeling using spherical superparamagnetic iron oxide (SPIO) nanoparticles containing different coatings, namely, organosilica, dextran, and poly(ethylene glycol) (PEG). These nanomaterials possess a similar SPIO core size of 6–7 nm. Together with their coatings, the overall sizes are 10–15 nm for all SPIO@SiO2, SPIO@dextran, and SPIO@PEG nanoparticles. These nanoparticles were investigated for their efficacies to be uptaken by rabbit bone marrow-derived MSCs without any transfecting agent. Experimentally, both SPIO@SiO2 and SPIO@PEG nanoparticles could be successfully uptaken by MSCs while the SPIO@dextran nanoparticles demonstrated limited labeling efficiency. The labeling durability of SPIO@SiO2 and SPIO@PEG nanoparticles in MSCs after three weeks of culture were compared by Prussian blue staining tests. SPIO@SiO2 nanoparticles demonstrated more blue staining than SPIO@PEG nanoparticles, rendering them better materials for MSCs labeling by direct uptake when durable intracellullar retention of SPIO is desired. Full article
(This article belongs to the Special Issue Surface Modification and Assembly of Magnetic Nanoparticle Materials)
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