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Metabolites
Special Issues
Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle
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Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 2853

Special Issue Editors

Prof. Dr. Paulo Cezar de Freitas Mathias

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Guest Editor
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá 87020-900, Brazil
Interests: rats; obesity; insulin secretion; monosodium glutamate; lactation; islets; protein dystrophy; blood glucose; catecholamines; mice
Dr. Lucas Paulo Jacinto Saavedra

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Guest Editor
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá 87020-900, Brazil
Interests: developmental programming of thermogenesis and energy expenditure
Dr. Rodrigo Mello Gomes

E-Mail Website
Guest Editor
Department of Physiological Sciences, Institute of Biological Sciences, University Federal of Goiás, Goiânia 74690-900, Brazil
Interests: DOHaD; obesity; Type 2 diabetes; metabolic programming

Special Issue Information

Dear Colleagues,

Obesity is a condition of major concern worldwide which is accompanied with several metabolic dysfunctions. Its prevalence is increasing around the world and the projections are that it will worsen even more in the future. Besides the canonical explanation of diet and physical activity, exposure to different stimuli during development, such as undernutrition, infections, and environmental contaminants, is of major concern to the Developmental Origins of Health and Disease (DOHaD). Taking into account the knowledge produced for searching for the causes, it is imperative that this knowledge is used for the proposal of innovative approaches to counteract these conditions. In this Special Issue, we aim to focus on novel etiological factors that may play a role in the development of obesity and metabolic dysfunction. But we are also interested in novel interventions that may help to “break this cycle of disease development”.

Prof. Dr. Paulo Cezar de Freitas Mathias
Dr. Lucas Paulo Jacinto Saavedra
Dr. Rodrigo Mello Gomes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • diabetes
  • DOHaD
  • metabolic programming
  • treatment
  • intervention
  • cardiovascular disease
  • metabolic syndrome

Published Papers (2 papers)

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Research

10 pages, 695 KiB  
Article
Obesity in Pregnancy as a Risk Factor in Maternal and Child Health—A Retrospective Cohort Study
by Miriam Orós, Marta Lorenzo, María Catalina Serna, Júlia Siscart, Daniel Perejón and Blanca Salinas-Roca
Metabolites 2024, 14(1), 56; https://doi.org/10.3390/metabo14010056 - 15 Jan 2024
Viewed by 1169
Abstract
The prevalence of overweight and obesity has risen dramatically in the last few years. This has led to an increase in both conditions in pregnant women. Obesity and overweight are associated with complications for both the mother and the newborn. The aim of [...] Read more.
The prevalence of overweight and obesity has risen dramatically in the last few years. This has led to an increase in both conditions in pregnant women. Obesity and overweight are associated with complications for both the mother and the newborn. The aim of this study is to determine the prevalence of obesity and its association with the risk of complications during pregnancy. Materials and Methods: We conducted a retrospective cohort study of pregnant women who delivered from 1 January 2012 to 31 December 2018. Results: A higher prevalence of obesity is observed in the group of women aged 35 or older. Women with a BMI > 25 present a higher risk of cesarean section (aOR 1.49, 95% CI: 1.37–1.61), preeclampsia (aOR 1.64, 95% CI: 1.19–2.26), high-risk pregnancy (aOR 2.34, 95% CI: 1.68–2.6), Apgar < 7 at one minute (aOR 1.53, 95% CI: 1.25–1.89) and macrosomia (aOR 2.08, 95% CI: 1.83–2.37). Maternal overweight and obesity are important determinants of the risk of complications for both the mother and the newborn. Full article
(This article belongs to the Special Issue Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle)
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11 pages, 453 KiB  
Article
Overweight or Obesity Rate and Risk Factors in First-Episode and Drug-Naïve Patients with Major Depressive Disorder with Comorbid Abnormal Lipid Metabolism: A Large-Scale Cross-Sectional Study
by Xiao Huang, Yuan Sun and Xiangyang Zhang
Metabolites 2024, 14(1), 26; https://doi.org/10.3390/metabo14010026 - 30 Dec 2023
Viewed by 1139
Abstract
Overweight and obesity are frequent symptoms in patients with major depressive disorder (MDD) and abnormal lipid metabolism (ALM). There are no studies on the rate, risk factors, and underlying mechanisms of overweight/obesity in Chinese patients with MDD with comorbid ALM. The purpose of [...] Read more.
Overweight and obesity are frequent symptoms in patients with major depressive disorder (MDD) and abnormal lipid metabolism (ALM). There are no studies on the rate, risk factors, and underlying mechanisms of overweight/obesity in Chinese patients with MDD with comorbid ALM. The purpose of this study was to examine the rate of overweight/obesity and the associated risk factors among Chinese patients with MDD first-episode and drug-naïve (FEDN) with comorbid ALM. This study was a cross-sectional research work. A total of 1718 patients were enrolled. Their clinical and laboratory data were obtained. All participants were assessed with the 17-item Hamilton Depression Rating Scale (HAMD), the Hamilton Anxiety Rating Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale. The plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triacylglycerols (TG), blood glucose concentrations, thyroid peroxidase antibody (A-TPO), thyoglubulin antibody (A-TG), thyroid-stimulating hormone (TSH), free thyoxine (FT4) and free triiodothyronine (FT3), and blood glucose concentrations were measured. ALM was identified as elevations in the plasma lipid values in this study. Of all the included subjects, the rate of ALM was 81.1%. The rate of obesity and overweight was 3.94% and 57.21%, respectively. Logistic regression analysis showed that TSH was the independent risk factor for overweight or obesity in MDD patients (adjusted OR = 1.158, 95%CI = 1.081–1.24, p < 0.001). The risk of developing overweight or obesity in MDD with ALM with comorbid TSH abnormalities was 2.176 times higher than those without TSH abnormalities (p < 0.001). Further linear regression showed TSH level (B = 0.1, t = 3.376, p = 0.001) and systolic blood pressure (B = 0.015, t = 2.351, p = 0.019) were risk factors for a higher body mass index (BMI). Our results demonstrate that being overweight is very frequent among patients with FEDN MDD with comorbid ALM but not obesity. TSH was the risk factor for overweight and obesity in MDD patients with comorbid ALM. Full article
(This article belongs to the Special Issue Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle)
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