Effects of Bioactive Compounds on Metabolic Syndrome

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Food Metabolomics".

Deadline for manuscript submissions: 16 September 2024 | Viewed by 3353

Special Issue Editors


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Guest Editor
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: functional food; antioxidant properties; polyphenols; phenolic acids; extraction; HPLC
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmacology, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: ion chromatography; environmental pollutants; endocrine disruptors; autism spectrum disorder

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Guest Editor
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: biological properties; liquid chromatography; antioxidants; extraction methods; functional food; polyphenols
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the term metabolic syndrome (i.e., MetS) became one of the most commonly used phrases in medical sciences. This concept is defined as many interrelated metabolic factors, the co-occurrence of which contributes the increaed risk of atherosclerotic cardiovascular diseases and type 2 diabetes. MetS includes, but is not limited to, obesity, impaired glucose tolerance, insulin resistance and/or hyperinsulinemia, dyslipidaemia, hypertension, or pro-inflammatory and pro-thrombotic conditions. The pathogenesis of this syndrome has not been fully understood. It is indicated that the predominant causes of MetS are primarily insulin resistance and visceral obesity; however, there are other plausible risk factors predisposed to metabolic syndrome. Furthermore, patients with MetS require substantial healthcare service, and consequently more medical professionals are involved in their treatment.

We welcome the submission of original research articles or review papers as contributions to this Special Issue of Metabolites, titled “Effects of Bioactive Compounds on Metabolic Syndrome”. This special edition aims to expand upon the knowledge on such an important health problem as MetS. We invite you to publish articles on the systematization of theories on this subject, as well as the patiogenesis, prevention, and treatment of metabolic syndrome.

Dr. Kamila Kasprzak-Drozd
Dr. Przemysław Niziński
Prof. Dr. Anna Oniszczuk
Guest Editors

Manuscript Submission Information

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Keywords

  • metabolic syndrome
  • bioactive compounds
  • secondary plant metabolites
  • cardiovascular disease
  • obesity
  • diabetes mellitus

Published Papers (1 paper)

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Research

20 pages, 3137 KiB  
Article
An Egg White-Derived Peptide Enhances Systemic Insulin Sensitivity and Modulates Markers of Non-Alcoholic Fatty Liver Disease in Obese, Insulin Resistant Mice
by Stepheny C. de Campos Zani, Ren Wang, Hellen Veida-Silva, Robin D. Clugston, Jessica T. Y. Yue, Marcelo A. Mori, Jianping Wu and Catherine B. Chan
Metabolites 2023, 13(2), 174; https://doi.org/10.3390/metabo13020174 - 24 Jan 2023
Cited by 3 | Viewed by 2244
Abstract
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a global health problem. Currently, no pharmacological treatment is approved for NAFLD. Natural health products, including bioactive peptides, are potential candidates to aid in the management of metabolic syndrome-related conditions, [...] Read more.
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a global health problem. Currently, no pharmacological treatment is approved for NAFLD. Natural health products, including bioactive peptides, are potential candidates to aid in the management of metabolic syndrome-related conditions, including insulin resistance and obesity. In this study, we hypothesized that an egg-white-derived bioactive peptide QAMPFRVTEQE (Peptide 2) would improve systemic and local white adipose tissue insulin sensitivity, thereby preventing high-fat diet-induced exacerbation of pathological features associated with NAFLD, such as lipid droplet size and number, inflammation, and hepatocyte hypertrophy in high-fat diet-fed mice. Similar to rosiglitazone, Peptide 2 supplementation improved systemic insulin resistance during the hyperinsulinemic-euglycemic clamp and enhanced insulin signalling in white adipose tissue, modulating ex vivo lipolysis. In the liver, compared with high-fat diet fed animals, Peptide 2 supplemented animals presented decreased hepatic cholesterol accumulation (p < 0.05) and area of individual hepatic lipid droplet by around 50% (p = 0.09) and reduced hepatic inflammatory infiltration (p < 0.05) whereas rosiglitazone exacerbated steatosis. In conclusion, Peptide 2 supplementation improved insulin sensitivity and decreased hepatic steatosis, unlike the insulin-sensitizing drug rosiglitazone. Full article
(This article belongs to the Special Issue Effects of Bioactive Compounds on Metabolic Syndrome)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Potential of chlorogenic acid in in the management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Animal studies and clinical trials – a non-systematic review
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